The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties [0.03%]
关于女性生殖道黏液流变特性的已知与未知
Luke Achinger,Derek F Kluczynski,Abigail Gladwell et al.
Luke Achinger et al.
Spermatozoa reach the fallopian tube during ovulation by traveling through the female reproductive tract mucus. This non-Newtonian viscoelastic medium facilitates spermatozoon movement to accomplish fertilization or, in some cases, blocks s...
Heavy Metal Meets Protein Homeostasis: Emerging Roles of F-Box Proteins? [0.03%]
重金属与蛋白稳态：F-盒蛋白的新角色？
Callie E W Crawford,George M Burslem
Callie E W Crawford
Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System [0.03%]
非线性老化的特征：生命分子阶段：老化过程中突然变化作为年龄分类系统潜在生物标志物的可能性
Maja Olecka,Helen Morrison,Steve Hoffmann
Maja Olecka
The traditional view of aging as a gradual, progressive process is increasingly being challenged. A growing body of evidence suggests the existence of abrupt transitions in the aging process, marked by sudden molecular shifts. Interestingly...
Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing [0.03%]
CRL家系中不同的应激调节因子：F-盒蛋白的新兴角色：Cullin-RING连接酶和应力感应
Jiwon Hwang,Linda Lauinger,Peter Kaiser
Jiwon Hwang
Cullin-RING ligases (CRLs) are central regulators of environmental and cellular stress responses, orchestrating diverse processes through the ubiquitination of substrate proteins. As modular complexes, CRLs employ substrate-specific adaptor...
Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions [0.03%]
在宿主与病原互作过程中可视化效应蛋白转导的实验方法
Verena Nadin Fritsch,Michael Hensel
Verena Nadin Fritsch
Bacterial pathogens deliver effector proteins into host cells by deploying sophisticated secretion systems. This effector translocation during host-pathogen interactions is a prerequisite for the manipulation of host cells and organisms and...
Patrick Wilmott,Leszek Lisowski
Patrick Wilmott
Intra-strand base pairing is possible when double-stranded DNA contains inverted repeats, but vanishingly improbable without so-called negative superhelicity. This superhelicity itself is conditional upon whether the molecule can retain tor...
Phosphoregulation of Microtubule Assembly and Disassembly for Phragmoplast Expansion During Plant Cytokinesis [0.03%]
植物胞质分裂过程中微管组装和拆卸的磷酸调控作用及对细胞板扩展的影响
Yuh-Ru Julie Lee,Bo Liu
Yuh-Ru Julie Lee
Plant cytokinesis results in the formation of the cell plate by the phragmoplast which contains dynamic microtubules serving as the track for the delivery of cell wall builders included in Golgi vesicles. During the centrifugal process of c...
The LAM Is Not Enough-An Idea to Watch Regarding Adipose Tissue Macrophages and Their Disease Relevance: Why Lipid-Associated Macrophage (LAM) Accumulation in Adipose Tissue Is a Systems Biology Problem [0.03%]
关于脂肪组织巨噬细胞及其疾病相关性的想法：为什么脂联巨噬细胞(LAM)在脂肪组织中的积累是一个系统生物学问题 -LAM是不够的
Lorenz Adlung
Lorenz Adlung
Environmental and Their Disruption of Integrin Signaling in Lipid Rafts [0.03%]
环境雌激素及其对脂筏中整联蛋白信号通路的干扰
Tina Izard
Tina Izard
Talin, a key integrin activator, is essential for cellular adhesion, signal transduction, and mechanical stability. Its transition between autoinhibited and active conformations allows dynamic regulation of adhesion in response to environme...
Gene Duplication and Alternative Splicing as Evolutionary Drivers of Proteome Specialization [0.03%]
基因重复和可变剪接作为进化中推动蛋白质组特化的驱动力
Federica Mantica,Manuel Irimia
Federica Mantica
Animals comprise hundreds of cell types, each with specialized biological functions. However, many genes expressed in each cell type belong to widely conserved gene families with ancestrally ubiquitous expression. This raises a paradox: how...