Current and Future Landscape of SERCAs' Functions in Non-Excitatory Cells and Diseases [0.03%]
当前和未来的非兴奋性细胞和疾病中SERCAs功能格局
Jingyan Yu,Hongyu Wang,Mengqian Ding et al.
Jingyan Yu et al.
Calcium (Ca2+) signaling as the primary intracellular second messenger orchestrates a myriad of physiological processes. Maintaining Ca2+ homeostasis relies on Ca2+ channels, pumps, exchangers, and buffers. Sarco/endoplasmic reticulum Ca2+-...
Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence [0.03%]
液体守护者：生物分子凝聚物通过隔离异染色质来抵御细胞衰老
Jia Xie,Ze-Guang Han
Jia Xie
Heterochromatin, a crucial constituent of the eukaryotic nucleus with highly conserved and transcriptionally silenced characteristics, plays a pivotal role in safeguarding genome stability, regulating nuclear morphology, and mediating cell ...
MYC Walks the Tightrope: Driving Cancer Proliferation While Mitigating Cellular Stress and Enabling Immune Escape [0.03%]
MYC走钢丝：在缓解细胞压力和实现免疫逃逸的同时促进癌症增殖
Sharon Prince,Carly Burmeister,Lucy Macharia
Sharon Prince
Intergenerational Enlargement of Human Organs as a Driver of Increased Cancer Risk? [0.03%]
跨世代器官增大是致癌风险增加的原因吗？
Costas Koufaris,Vicky Nicolaidou
Costas Koufaris
The incidence of multiple cancer types is increasing in younger generations, with the underlying causes being debated. Here, we propose that environmentally-driven organ enlargement is a novel mechanism contributing to the observed increase...
Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health [0.03%]
人体宫颈芯片：一种研究宫颈黏膜和微生物组在女性生殖健康中作用的临床前模型
Zohreh Izadifar,Anna Stejskalova,Aakanksha Gulati et al.
Zohreh Izadifar et al.
Advancements in women's reproductive health have been hindered by insufficient knowledge and the underrepresentation of women in research, leading to symptom-focused care with poor outcomes. Modeling female reproductive biology and disease ...
Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing [0.03%]
紧凑型起源及其查找指南：ORC的全基因组许可指南
Christian Speck,Luitpold Maximilian Reuter
Christian Speck
Origin licensing is the first step in the fundamental process of DNA replication, which ensures the accurate transmission of an organism's genetic information. Studies in budding yeast have provided crucial insights into replication origins...
When G Protein-Coupled Receptor Signaling Meets the Primary Cilium: Implications for Sonic Hedgehog Signaling [0.03%]
G蛋白偶联受体信号通路与原纤毛相遇——对音猬因子信号通路的意义
Sung-Eun Kim
Sung-Eun Kim
Exposure to Extreme Heat Increases Preterm Birth Risk: Hypothetical Pathophysiological Mechanisms [0.03%]
暴露于极端高温增加早产风险：假定的病理生理机制
Isidore Mushimiyimana,Lauren Richardison,Ananth Kumar Kammala et al.
Isidore Mushimiyimana et al.
Preterm birth (PTB), delivery before 37 weeks of gestation, is the leading cause of neonatal mortality globally, accounting for nearly half of all neonatal deaths. While numerous established risk factors for PTB have been identified, ongoin...
Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition [0.03%]
安集思蛋白——一个四季常青的大家庭：从钙依赖性膜代谢到RNA识别
Anni Vedeler,Gian Gaetano Tartaglia,Annalisa Pastore
Anni Vedeler
Annexins are a protein family well known to bind to phospholipids in a calcium-dependent way. They are involved in several different crucial cellular processes such as cell division, calcium signaling, membrane repair, vesicle trafficking, ...
Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases [0.03%]
线粒体和内质网接触位点在神经退行性疾病中的蛋白稳态应激反应调节作用
Seiji Watanabe,Koji Yamanaka
Seiji Watanabe
Recent evidence indicates that the mitochondria-endoplasmic reticulum (ER) contact site is a novel microdomain essential for cellular homeostasis. Various proteins are accumulated at the mitochondria-associated membrane (MAM), an ER subcomp...