Dave Speijer
Dave Speijer
Retina Development in Vertebrates: Systems Biology Approaches to Understanding Genetic Programs: On the Contribution of Next-Generation Sequencing Methods to the Characterization of the Regulatory Networks Controlling Vertebrate Eye Development [0.03%]
脊椎动物视网膜发育：系统生物学方法在理解遗传程序中的应用——新一代测序技术对表征调控脊椎动物眼睛发育的调节网络的贡献
Lorena Buono,Juan-Ramon Martinez-Morales
Lorena Buono
The ontogeny of the vertebrate retina has been a topic of interest to developmental biologists and human geneticists for many decades. Understanding the unfolding of the genetic program that transforms a field of progenitors cells into a fu...
Ronja Reinhardt,Linda Truebestein,Heiko A Schmidt et al.
Ronja Reinhardt et al.
The recent discovery and structure determination of a novel ubiquitin-like dimerization domain in protein kinase D (PKD) has significant implications for its activation. PKD is a serine/threonine kinase activated by the lipid second messeng...
Far from Inert: Membrane Lipids Possess Intrinsic Reactivity That Has Consequences for Cell Biology [0.03%]
膜脂并非惰性物质：膜脂具有内在反应性并对细胞生物学产生影响
John M Sanderson
John M Sanderson
In this article, it is hypothesized that a fundamental chemical reactivity exists between some non-lipid constituents of cellular membranes and ester-based lipids, the significance of which is not generally recognized. Many peptides and sma...
The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation [0.03%]
再生修复的生物物理研究提出了关于生物学因果关系的新观点
Michael Levin
Michael Levin
Evolution exploits the physics of non-neural bioelectricity to implement anatomical homeostasis: a process in which embryonic patterning, remodeling, and regeneration achieve invariant anatomical outcomes despite external interventions. Lin...
The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus [0.03%]
细胞核中间层腔结构参与细胞核的结构和功能组织
Thomas Cremer,Marion Cremer,Barbara Hübner et al.
Thomas Cremer et al.
This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing speckles and nuclear bodies. It is postulated that the IC pro...
Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing [0.03%]
跨越物种边界的转座元件：外源性转座元件的体细胞获得是基因组不稳定性、表观遗传失调、炎症、衰老和老化的催化剂
Timothy J Chalmers,Lindsay E Wu
Timothy J Chalmers
The de-repression of transposable elements (TEs) in mammalian genomes is thought to contribute to genome instability, inflammation, and ageing, yet is viewed as a cell-autonomous event. In contrast to mammalian cells, prokaryotes constantly...
Modifying Post-Translational Modifications: A Strategy Used by Archaea for Adapting to Changing Environments?: Manipulating the Extent, Position, or Content of Post-Translational Modifications May Help Archaea Adapt to Environmental Change [0.03%]
修改翻译后修饰：古菌适应环境变化的策略吗？：操控翻译后修饰的程度、位置或内容可能有助于古菌适应环境变化
Jerry Eichler
Jerry Eichler
In concert with the selective pressures affecting protein folding and function in the extreme environments in which they can exist, proteins in Archaea have evolved to present permanent molecular adaptations at the amino acid sequence level...
Adriano R Lameira,Josep Call
Adriano R Lameira
Language does not fossilize but this does not mean that the language's evolutionary timeline is lost forever. Great apes provide a window back in time on our last prelinguistic ancestor's communication and cognition. Phylogeny and cladistic...