Biomolecular Condensates at the Crossroads of HIV Infection and Immune Evasion [0.03%]
生物分子凝聚体在HIV感染和免疫逃避的交汇处
Selen Ay,Antonio Marino Cerrato,Francesca Di Nunzio
Selen Ay
Nuclear entry of HIV-1 viral cores triggers the formation of phase-separated membraneless organelles called HIV-1-MLOs. Numerous unknowns remain regarding the persistence, in vivo formation, and function of these recently discovered condens...
Zebrafish as an Anti-Isogenic Vertebrate Model and What It Reveals About Genetic Background and Reproducibility [0.03%]
斑马鱼作为抗同种异体的脊椎动物模型及其对于基因背景和可重复性研究的意义
Álvaro J Arana,Laura Sánchez
Álvaro J Arana
Isogenic lines, understood here as lines approaching genome-wide homozygosity while remaining fertile and stable across successive generations, have transformed genetics and toxicology in vertebrate models. In zebrafish (Danio rerio), howev...
Unifying Retaria Research: A Common Framework for Studying Foraminifera and Radiolaria [0.03%]
统一研究_retaria_: 研究_foraminifera_和_radiolaria_的通用框架
Miguel M Sandin,Nicole L Coots,Nicolaas Glock et al.
Miguel M Sandin et al.
Spanning over 500 million years, the fossil record of Retaria is a cornerstone of paleobiology, paleoclimate reconstruction, and stratigraphy. Yet, the constitutive branches of Retaria, Foraminifera, and Radiolaria, not only have been studi...
Ian McLauchlan,Jack White,Mohamed Eldeeb
Ian McLauchlan
Proteostasis hinges on the precise recognition and elimination of damaged proteins through the ubiquitin-proteasome system (UPS), where E3 ubiquitin ligases recognize degradation signals, or degrons. While degrons have traditionally been vi...
Spider Mites: Genetic Models to Inform Herbivore and Chelicerate Biology [0.03%]
蛛螨：用于阐明植食性和节肢动物生物学的遗传模式生物
Richard M Clark,Sander De Rouck,Marilou Vandenhole et al.
Richard M Clark et al.
Spider mites (Acari: Trombidiformes; Tetranychidae) are globally important herbivore pests of crops. They have also become powerful genetic models for understanding chelicerate biology and the evolution of xenobiotic (i.e., pesticide) resis...
Mitochondrial Signaling and Stress Responses, Key Regulators of Aging and Longevity [0.03%]
线粒体信号转导和应激反应是衰老和长寿的关键调控因素
Yi Sheng,Zachary Markovich,Sung Min Han et al.
Yi Sheng et al.
Mitochondria are vital not only for energy production but also for regulating signaling pathways that influence aging. While mitochondrial dysfunction contributes to age-related decline, emerging evidence shows that mild, regulated mitochon...
Martin R Schiller
Martin R Schiller
This paper proposes an extension of the traditional Central Dogma of molecular biology to a more dynamic model termed the Central Dogma cycle (CDC) and a broader network called the Central Dogma cyclic network (CDCN). While the Central Dogm...
Time to Say Goodbye [0.03%]
说再见的时候到了
Kerstin Brachhold
Kerstin Brachhold
Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research [0.03%]
单细胞RNA测序在神经科学中的作用与应用
Katarina Kapuralin,Claude Desplan,Rana Naja El-Danaf
Katarina Kapuralin
The brain's vast cellular diversity and complex developmental programs have long inspired neuroscientists' efforts to understand its organization and function. Recent advances in single-cell RNA sequencing (scRNA-seq) have transformed this ...