Artificial stone dust affects oxidative stress and epithelial barrier in CALU 3 cells [0.03%]
人造石粉对CALU 3细胞氧化应激和上皮屏障的影响
Noa Ophir,Elizabeth Fireman,Mordechai Reuven Kramer et al.
Noa Ophir et al.
Aim: Artificial Stone Dust (ASD) exposure has been identified as a significant health risk for workers, leading to oxidative stress, inflammatory responses, and potential systemic autoimmune diseases due to its high crystalline silica conte...
Nasal mucosa-derived ecto-mesenchymal stem cells ameliorate LPS-induced acute lung injury [0.03%]
鼻黏膜来源的外胚间充质干细胞改善脂多糖诱导的大鼠急性肺损伤
Yifei Yang,Junguo Chen,Jiaojiao Chen et al.
Yifei Yang et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with significant morbidity and mortality rates. Mesenchymal stem cells (MSCs) derived from nasal mucosa, known as EMSCs, have demonstrated therapeutic pot...
Screening and validation of stable housekeeping genes in lung organoids and rat lung models under tobacco exposure [0.03%]
烟叶暴露下人源肺类器官和大鼠肺模型稳定内参基因筛选与验证
Yi Liu,Jing Zhang,Xi Fang et al.
Yi Liu et al.
In recent years, with the increasing severity of air pollution and environmental degradation, research on lung-related diseases has become more intensive. Lung organoids, as 3D in vitro culture models, can simulate the local microenvironmen...
PM2.5 induces ferroptosis in chronic obstructive pulmonary diseases via the GSK-3β/NRF2 pathway [0.03%]
PM2.5通过GSK-3β/NRF2信号途径诱导慢性阻塞性肺疾病中铁死亡发生
Dong Ye,Jie Ou,Dongshuang Zhu et al.
Dong Ye et al.
Background: Recent studies have shown that fine particulate matter (PM2.5) exposure is a key harmful risk factor for chronic obstructive pulmonary disease (COPD) and PM2.5-associated ferroptosis plays an important role during the process of...
METTL14/ YTHDF1 mediates m6A modification of PTBP1 to regulate PDGF-BB-induced airway smooth muscle cell function [0.03%]
METTL14/YTHDF1介导的PTBP1m6A修饰调节PDGF-BB诱导的气道平滑肌细胞功能
Canming Qiu,Zhenzhu Liao,Pingping Guo et al.
Canming Qiu et al.
Background: Increased proliferation and migration of abnormal airway smooth muscle cells (ASMCs) are significantly associated with asthma. This study aimed to investigate the effects of methyltransferase-like 14 (METTL14)...
AIP4 inhibits NPE pulmonary microvascular endothelial cell apoptosis and barrier failure via regulation of TRPV4 subcellular location in vitro [0.03%]
AIP4通过调节NPE肺微血管内皮细胞中TRPV4的亚细胞定位来抑制细胞凋亡和屏障功能障碍（体外）
Mingbo Luo,Kaihua Yang,Yingtao Wu et al.
Mingbo Luo et al.
Background: Neurogenic pulmonary edema (NPE) is a severe complication of subarachnoid hemorrhage that aggravates pulmonary microvascular endothelial barrier dysfunction. In this study, we aimed to explore the role of TRPV4 in NPE progressio...
USP4-mediated deubiquitination of SRC-1 regulates macrophage polarization and asthma inflammation [0.03%]
USP4介导的SRC-1去泛素化调控巨噬细胞极化及哮喘炎症反应
Lina Yan,Yun Shen,Jing Song et al.
Lina Yan et al.
Background: Asthma, the most common chronic respiratory disorder affecting individuals of all ages, is driven by inflammation that leads to airway hyperresponsiveness, airway wall remodeling, and mucus production. While inhaled corticostero...
Hypobaric hypoxia promotes the production of IL-10 of lung NKT cells in HAPE rats to fight inflammation [0.03%]
低氧诱导NKT细胞产生IL-10参与急性高山病免疫炎症反应下调的机制研究
Dewei Li,Chun Wang,Zhaoquan Su et al.
Dewei Li et al.
Background: There are environment-dependent pro-inflammatory and anti-inflammatory pathways during exposure to high altitudes. Although inhibiting the inflammatory pathway can alleviate high altitude pulmonary edema (HAPE), it is currently ...
Store-operated Ca2+ entry contributes to the ASM phenotype transition in asthma [0.03%]
店藏钙离子进入机制对哮喘中气道平滑肌表型转换的贡献作用研究
Hangqi Ni,Ting Li,Junjun Chen et al.
Hangqi Ni et al.
Aim of the study: Phenotype modulation of airway smooth muscle cells (ASMC), characterized by a shift toward a more proliferative and synthetic phenotype from contractile cells, plays a crucial role in airway remodeling i...
Zebrafish as a model for investigating Klebsiella pneumoniae-driven lung injury and therapeutic targets [0.03%]
斑马鱼作为研究肺炎克雷伯菌驱动的肺损伤和治疗靶点的模型
Jian Ye,Lei Lu,Xiao-Hong Rui et al.
Jian Ye et al.
Background: Lung injury induced by Klebsiella pneumoniae infection presents a significant challenge, with complex molecular mechanisms driving tissue damage and immune dysregulation. This study aimed to establish a zebrafish model of K. pne...