The downregulation of RAB10 by miR-574-5p alleviates the inflammatory response in neonatal respiratory distress syndrome [0.03%]
miR-574-5p通过下调RAB10缓解新生儿呼吸窘迫综合征的炎症反应
Yanan Ji,Yangping Zhou,Ludan Deng et al.
Yanan Ji et al.
Aim: The diagnosis of neonatal respiratory distress syndrome NRDS relies on progressive breathing difficulties after birth, abnormal blood oxygen levels, and typical chest X-ray images. However, this diagnostic method has...
Copper homeostasis dysregulation and cuproptosis in respiratory diseases [0.03%]
铜稳态紊乱和铜细胞死亡在呼吸系统疾病中的作用
Yusheng Gao,Xiuping Chen,Yixin Xu
Yusheng Gao
Cuproptosis, a recently identified form of regulated cell death, relies on accumulated copper (Cu) ions and a disrupted mitochondrial respiratory chain. The role of cuproptosis in various diseases, especially respiratory diseases of pulmona...
IL-36G drives sepsis-induced lung injury via NF-κB-dependent activation of the NLRP3 inflammasome in macrophage pyroptosis [0.03%]
白细胞介素36G通过NF-κB依赖的NLRP3炎性小体活化驱动促脓毒症巨噬细胞Pyroptosis的肺损伤
Mingguo Yan,Zhixin Chen,Yuan Song et al.
Mingguo Yan et al.
Background: Sepsis is a critical illness marked by widespread inflammation and failure of multiple organs. Pyroptosis and NLRP3 inflammasome activation play critical roles in sepsis pathogenesis. However, the involvement ...
Targeted delivery of Follistatin-like 1 siRNA via biodegradable nanoparticles attenuates bleomycin-induced pulmonary fibrosis in mice [0.03%]
载有Follistatin-like 1的可生物降解纳米颗粒通过靶向给药来缓解bleomycin诱导的小鼠肺纤维化作用
Xue Li,Maolin Yao,Min Yu et al.
Xue Li et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disorder that often leads to fatal outcomes, characterized by the aberrant proliferation of myofibroblasts and excessive depos...
Inhibitory effects of METTL3 on airway smooth muscle cell proliferation and migration via lncRNA GAS5/miR-29c-3p/VAMP2 axis [0.03%]
METTL3通过lncRNA GAS5/miR-29c-3p/VAMP2轴抑制气道平滑肌细胞增殖和迁移的作用机制研究
Xia Xi,JunYing Guo,ShuXiang Sui et al.
Xia Xi et al.
Objective: Asthma development is significantly influenced by the abnormal proliferation and migration of human airway smooth muscle cells (HASMCs). The aim of this study was to investigate the role and molecular mechanisms of the m6A methyl...
Effect and mechanism of chemokine receptor 1 in airway inflammation in a mouse model of chronic obstructive pulmonary disease [0.03%]
化学引诱素受体1在慢性阻塞性肺疾病小鼠模型气道炎症中的作用及机制研究
Wei Wei,Suzhen Ju,Yanfang Yu et al.
Wei Wei et al.
Objective: We aimed to investigate the role and mechanisms of chemokine receptor 1 (CCR1) in airway inflammation in chronic obstructive pulmonary disease (COPD) mice. ...
Nuclear accumulated µ-calpain enhances FoxO3a phosphorylation in AT2 cell and exacerbates pulmonary fibrosis [0.03%]
核内聚集的µ-钙蛋白酶通过增强AT2细胞中FoxO3a磷酸化促进肺纤维化加重
Qiao Li,Yu Tian,Yu-Tong Ye et al.
Qiao Li et al.
Background: µ-calpain is implicated in idiopathic pulmonary fibrosis (IPF), however its role in the aberrant alveolar epithelial type II (AT2) cells differentiation, and its relationship with FoxO3a, an important transcr...
Extracellular matrix and immune dysfunction: An overlooked relationship in idiopathic pulmonary fibrosis [0.03%]
细胞外基质与免疫功能障碍：特发性肺纤维化中被忽视的关系
Upama Nyaupane,Kerri A Johannson,Margaret M Kelly et al.
Upama Nyaupane et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal disease. Current clinically approved treatments slow disease progression but are not curative. Thus, there is a critical need to better define the pathogenic mechanisms of IPF and d...
Pulmonary metabolic imbalances and mitochondrial ultrastructural remodeling in lipopolysaccharide-induced acute respiratory distress syndrome [0.03%]
脂多糖诱导的急性呼吸窘迫综合征中的肺代谢失衡及线粒体超微结构重塑
Wen Tan,Li Yu,Maomao Liu et al.
Wen Tan et al.
Study aim: Acute respiratory distress syndrome (ARDS) is a critical disease of high mortality. Recent studies have confirmed that metabolic alterations and mitochondrial dysfunction is in involved in the progression of va...
Artificial stone dust affects oxidative stress and epithelial barrier in CALU 3 cells [0.03%]
人造石粉对CALU 3细胞氧化应激和上皮屏障的影响
Noa Ophir,Elizabeth Fireman,Mordechai Reuven Kramer et al.
Noa Ophir et al.
Aim: Artificial Stone Dust (ASD) exposure has been identified as a significant health risk for workers, leading to oxidative stress, inflammatory responses, and potential systemic autoimmune diseases due to its high crystalline silica conte...