Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy [0.03%]
高效载荷的二氢podophyllotoxin纳米药物递送系统用于癌症治疗
Chang Zu,Yinglan Yu,Caiwei Yu et al.
Chang Zu et al.
Cancer is a kind of malignant diseases that threatens human health and the research application of anti-tumor drug therapeutics is growingly always been focused on. Many new compounds with great anticancer activity were synthesized but cann...
Comparative Study
Drug delivery. 2020 Dec;27(1):248-257. DOI:10.1080/10717544.2020.1716875 2020
Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer [0.03%]
具优异稳定性的水合姜黄素纳米棒改善乳腺癌的体内外活性
Yian Wang,Tiantian Huang,Haowen Li et al.
Yian Wang et al.
Due to their various biological activities that are beneficial to human health and antitumor effect, flavonoid compounds have attracted much attention in recent years. Hydrous icaritin (HICT) was such a flavonoid that can inhibit the growth...
Comparative Study
Drug delivery. 2020 Dec;27(1):228-237. DOI:10.1080/10717544.2020.1716877 2020
Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents [0.03%]
一类新的异环去氢松酯胺衍生物的合成及其作为潜在的抗增殖和促凋亡剂的作用研究
Fengyi Zhao,Xu Sun,Wen Lu et al.
Fengyi Zhao et al.
Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazi...
Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery [0.03%]
壳聚糖/磷脂纳米颗粒：从基本原理到用于高级药物输送的制备
Qingming Ma,Yang Gao,Wentao Sun et al.
Qingming Ma et al.
With the development of nanotechnology, self-assembled chitosan/phospholipid nanoparticles (SACPNs) show great promise in a broad range of applications, including therapy, diagnosis, in suit imaging and on-demand drug delivery. Here, a brie...
Galactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma [0.03%]
半乳糖修饰的硒纳米颗粒靶向递送多柔比星到肝癌细胞
Yu Xia,Jiayu Zhong,Mingqi Zhao et al.
Yu Xia et al.
Galactose-modified selenium nanoparticles (GA-SeNPs) loading with doxorubicin (DOX) for hepatocellular carcinoma (HCC) therapy was investigated in this paper. Selenium nanoparticles (SeNPs) were modified with galactose as tumor targeting mo...
A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment [0.03%]
克服血脑屏障和脑肿瘤屏障改善胶质母细胞瘤小分子化疗药物递送的全面综述
Da Wang,Chao Wang,Liang Wang et al.
Da Wang et al.
Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly resistant to conventional radiotherapy and chemotherapy, and cannot be effectively controlled by surgical resection. Due to inevitable recurrence of GBM, i...
Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells for enhanced apoptosis and reversed multidrug resistance [0.03%]
载顺铂-齐墩果酸混合纳米颗粒胃癌细胞协同增效作用增强凋亡和逆转多药耐药性研究
Danyang Li,Ruixue Cui,Shuning Xu et al.
Danyang Li et al.
Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bot...
Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo [0.03%]
一种逐层组装的PH值敏感型药物载体纳米粒子及其体内可控释药和增强疗效研究
Wanfu Men,Peiyao Zhu,Siyuan Dong et al.
Wanfu Men et al.
In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(β-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled re...
Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis [0.03%]
载米诺环素PLGA静电纺丝膜可预防实验性牙周病的牙槽骨吸收
Yihui Ma,Jinlin Song,Huthayfa N S Almassri et al.
Yihui Ma et al.
Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish...
Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles [0.03%]
新型愈创薁黄酮载药TPGS/Soluplus混合型纳米胶束的制备、评价及大鼠代谢研究
Xue Feng,Yuting Chen,Luya Li et al.
Xue Feng et al.
Amentoflavone (AMF) is a kind of biflavonoids existing in Ginkgo biloba leaves. It has many biological activities, such as antioxidant, anti-inflammatory, anti-bacterial, antiviral, hypoglycemic, anti-tumor and inducing apoptosis. However, ...