Enhanced in vitro and in vivo antifungal efficacy against Candida albicans of nanostructured lipid carrier loaded with benzyl isothiocyanate extracted from Carica papaya L. seeds [0.03%]
纳升脂质载体装载木瓜籽苯基异硫氰酸酯增强对白念珠菌的体内外抗真菌功效
Zelin Zheng,Zijie Li,Mingqi Yu et al.
Zelin Zheng et al.
Candida albicans is the most prominent conditional fungal pathogen, which can cause systemic candidiasis when an individual becomes immunocompromised. The widespread and long-term use of azoles like fluconazole (FLC) has led to a significan...
Inhalable nanoparticle-based delivery systems for the treatment of pulmonary infections: Status quo and barrier-overcoming strategies [0.03%]
用于治疗肺部感染的可吸入纳米颗粒递送系统：现状及克服障碍策略
Yihong Gao,Wenhao Wang,Xiao Yue et al.
Yihong Gao et al.
Pulmonary infection is a serious public health challenge with high morbidity and mortality. The employment of antibiotics is the first-line treatment for pulmonary infections, while other novel anti-infection agents, such as antimicrobial p...
Seeking a common human factors language for the development and testing of injection devices [0.03%]
寻找注射装置开发和测试的共同人机工程学语言
Megan O Conrad,Molly E Laird,Mary Beth Privitera et al.
Megan O Conrad et al.
Injection devices include drug-device combination products incorporating a needle for subcutaneous medication delivery. Often utilized by patients and caregivers, it is important for injection device user interface (UI) design to be intuiti...
Ultrasound targeted microbubbles for theranostic applications in liver diseases: from molecular imaging to targeted therapy [0.03%]
超声微泡在肝病诊疗中的应用：从分子影像到靶向治疗
Chujun Zhang,Qiaoyu Zhang,Qiao Xu et al.
Chujun Zhang et al.
Liver diseases, particularly chronic conditions leading to cirrhosis and hepatocellular carcinoma, represent a major global health burden with high mortality rates, necessitating innovative diagnostic and therapeutic approaches. Ultrasound-...
Letter to the Editor regarding 'Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study' [0.03%]
关于评价护士对新型体内药物递送系统（相对于手动注射器）的偏好的调查研究的来信
Rohan Medhekar,Laura Clark,Santosh Gautam et al.
Rohan Medhekar et al.
Enhancing targeted delivery and efficacy of PEGylated liposomal doxorubicin with liposomal minoxidil: comprehensive in silico, in vitro, and in vivo tumor model studies [0.03%]
全面的基于计算机、体外和体内肿瘤模型研究改进聚乙二醇化脂质包封多柔比星与莫西沙腙脂质体的靶向输送及疗效
Vahideh Mohammadzadeh,Leila Arabi,Seyedeh Maryam Hosseinikhah et al.
Vahideh Mohammadzadeh et al.
The therapeutic efficacy of nanoparticle (NP)-encapsulated cytotoxic drugs has remained limited by poor penetration into solid tumors. To address this challenge, we developed a novel strategy using minoxidil-loaded nanoliposomes (Lip-MXD) t...
Letter to the Editor regarding 'Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study' [0.03%]
关于“评估护士对新型体内药物输送系统（用于大体积皮下给药）相对于手动注射器的偏好：一项调查研究”的来信
Mehul Desai,Beth Faiman,Lisa A Gorski et al.
Mehul Desai et al.
Characteristics, preparation and applicability in oral delivery systems of cellulose ether-based buccal films [0.03%]
基于纤维素醚的颊胶片的特性、制备及口腔递药系统中的应用性研究
Hong Cheng,Youjie Wang,Yanlong Hong et al.
Hong Cheng et al.
With the rapid development of buccal films (BFs), the demand for film-forming materials and preparation techniques has increased. Cellulose ethers (CEs) exhibit favorable properties, such as effective film formation, mucosal adhesion, and b...
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors [0.03%]
用于皮肤肿瘤的免疫调节加载微针阵列的靶向药物传输
Akmal H Sabri,Fiona Smith,Zachary Cater et al.
Akmal H Sabri et al.
Topical therapy with imiquimod in a cream [5% w/w imiquimod cream (Aldara™)] for the treatment of nodular basal cell carcinoma (BCC) currently results in low cure rates, attributed to low imiquimod permeation. Herein we have developed nove...
Biomimetic cancer cell membrane-enriched vitamin E-stapled gemcitabine-loaded TPGS micelles for pancreatic cancer therapy [0.03%]
基于维生素E-封端吉西他滨的TPGS仿生脂质体用于胰腺癌治疗
Miguel Pereira-Silva,Luis Diaz-Gomez,Bárbara Blanco-Fernandez et al.
Miguel Pereira-Silva et al.
Pancreatic cancer (PC) is currently a leading cause of death worldwide and its incidence is expected to increase in the following years. Chemotherapy with gemcitabine (GEM) is precluded by extensive enzymatic inactivation and clearance, and...