Advanced cell-derived drug delivery systems for pulmonary diseases: from bench to bedside [0.03%]
用于肺部疾病的细胞衍生药物递送系统：从实验室到临床应用
Fei Li,Wenjie Xu,Junyong Wu et al.
Fei Li et al.
Nowadays, pulmonary diseases (PDs) are among the leading causes of mortality worldwide. Conventional therapeutic approaches exhibit disappointing efficacies due to difficulty in drug delivery and systemic cytotoxicity. In recent years, nove...
Sequential nanotheranostics based on hollow mesoporous silica loaded doxorubicin and seed kernel extract from Mangifera indica L. as adjuvant therapy against hepatocellular carcinoma [0.03%]
基于多西环素和杧果核提取物的中空介孔硅纳米治疗诊断体系在肝细胞癌辅助治疗中的应用
Arunsajee Sae-Be,Jiraporn Leanpolchareanchai,Piyaporn Plommaithong et al.
Arunsajee Sae-Be et al.
Mango seed kernel extract (MSKE) and its phytochemical compositions were investigated for their anticancer activities and synergistic effects with doxorubicin (DOX) against hepatocellular carcinoma (HCC) in both 2D and 3D culture models. Mo...
M Singh,G Mazaheri-Tehrani,I Martin-Fabiani et al.
M Singh et al.
Extracellular vesicles (EVs) are promising drug delivery systems (DDSs). Electroporation is widely applied in the loading of therapeutic payloads but has not been optimized for EV loading. Understanding the potential effects of electroporat...
Integrating micro-needle jet injection and sustained GLP-1 therapy with structured feeding: a comprehensive strategy for obesity management [0.03%]
微针射流注射联合缓释GLP-1治疗及结构化饮食：肥胖管理的综合策略
Chen Zhang,Luoxin Long,Hong Hu et al.
Chen Zhang et al.
Obesity is a global health crisis strongly linked to increased risk of type 2 diabetes, cardiovascular diseases, and other metabolic disorders. Glucagon-like peptide-1 (GLP-1) has emerged as an effective macromolecular therapeutic agent for...
Adipose tissue-targeted drug delivery for treating obesity: current opportunities and challenges [0.03%]
针对肥胖的脂肪组织药物递送：当前机遇与挑战
Taimin Luo,Lei Chen,Kun Tu et al.
Taimin Luo et al.
Obesity has emerged as a global public health crisis in the 21st century, with its prevalence continuing to rise worldwide. Beyond its well-established links to metabolic diseases (diabetes, hypertension, dyslipidemia, and cardiovascular di...
Use of hydrophilic pharmaceutical excipients to modulate release of metal ions from silicone elastomers [0.03%]
亲水性药用辅料调节硅橡胶中金属离子释放的方法
Xin Shen,Xinyu Zhao,Clare F McCoy et al.
Xin Shen et al.
Silicone elastomers based on polydimethylsiloxane are biocompatible and non-biodegradable thermosetting polymers used in various drug delivery applications, including subdermal implants, vaginal rings, and intrauterine devices. Without exce...
Dexamethasone conjugation to an Avidin-Nucleic-Acid-NanoASsembly eliminates the steroid plasma absorption, enhancing selective lung tropism in a murine model of pulmonary fibrosis [0.03%]
地塞米松结合Avidin-核酸纳米载体后可消除激素的全身吸收，提高在肺纤维病鼠模型中的选择性定位效应
Annalisa Morelli,Elisa Schiavon,Martina Bruna Violatto et al.
Annalisa Morelli et al.
Despite their anti-inflammatory activity, corticosteroids are limited in clinic due to poor selectivity and their side effects. The ability to cross biological barriers makes them powerful yet unspecific, leading to toxicity and a low thera...
Albumin-based nanoparticles encapsulating SN-38 demonstrate superior antitumor efficacy compared to irinotecan [0.03%]
与伊立替康相比，基于白蛋白的SN-38载药纳米粒展示出更优的抗肿瘤效果
Guojun Xiong,Shengxi Li,Andreas G Schätzlein et al.
Guojun Xiong et al.
Efficient formulation of SN-38 for broad-spectrum chemotherapy remains an unmet medical need. The limited solubility of SN-38 in both aqueous and organic solvents poses a major challenge for formulation development. As a result, the predomi...
Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina [0.03%]
聚乙二醇和透明质酸修饰对脂质纳米颗粒介导的mRNA在犬视网膜递送的影响研究
Tatyana Appelbaum,David A Smith,Kei Takahashi et al.
Tatyana Appelbaum et al.
Efficient messenger ribonucleic acid (mRNA) delivery to the retina remains challenging. This study investigated the effects of various polyethylene glycol (PEG) derivatives on the stability and uptake of cationic lipid-based mRNA lipoplexes...
Advances in oral treatment of inflammatory bowel disease using protein-based nanoparticle drug delivery systems [0.03%]
基于蛋白质的纳米粒递药系统在治疗炎症性肠病中的研究进展
Zhihao Lin,Ziheng Zhao,Xianrui Lin et al.
Zhihao Lin et al.
Inflammatory bowel disease (IBD) comprises chronic autoimmune disorders with significant morbidity, highlighting the need for advanced, noninvasive, targeted therapies. Protein-based nanoparticle drug delivery systems (PNP-DDSs) have emerge...