A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction [0.03%]
一种用于高通量血脑屏障渗透性预测的替代屏障模型：将LLC-PK1-MOCK / MDR1细胞和溶酶体捕获修正相结合的方法
Juanwen Hu,Xue Jiang,Cong Li et al.
Juanwen Hu et al.
To mitigate risks in central nervous system (CNS) drug development, we established a high-throughput in vitro blood-brain barrier (BBB) model using LLC-PK1-MOCK and LLC-PK1-MDR1 cells in a Transwell system, aiming to replicate in vivo brain...
Targeted strategy by curcumin and tideglusib biomimetic nano-systems alleviates oxidative stress and inflammation under ischemic stroke [0.03%]
靶向姜黄素和Tideglusib仿生纳米系统策略缓解缺血性卒中氧化应激与炎症作用机制研究
Jiajia Li,Yiliang Yang,Meng Lin et al.
Jiajia Li et al.
Ischemic stroke represents one of the leading causes of disability and death worldwide. Neuroprotection aimed at mitigating oxidative stress and inflammation is crucial for improving the prognosis of patients. However, the inadequate accumu...
Enhancing GSDME-induced pyroptosis through low-dose doxorubicin/biflavonoid derivative co-loaded nanodisc in hepatocellular carcinoma [0.03%]
低剂量多柔比星/双黄酮衍生物共载纳米盘增强GSDME介导的焦亡在肝癌中的作用
Yang Wang,Yanan Fu,Meiying Wu et al.
Yang Wang et al.
The chemotherapeutic drug doxorubicin (DOX) has been demonstrated to trigger pyroptosis in tumor cells at exceptionally high concentrations. Nevertheless, the administration of DOX at suprapharmacological doses could cause acute off-target ...
Neuromodulation with low-intensity pulsed ultrasound (Lipus) combined with curcumin-gold nanoparticles (Cur-AuNPs) in an Alzheimer's disease model [0.03%]
结合低强度脉冲超声（Lipus）和姜黄素-金纳米粒子（Cur-AuNPs）进行神经调节以治疗阿尔茨海默病模型中的淀粉样蛋白病理变化
Laura de Roch Casagrande,Eduarda Behenck Medeiros,Ligia Milanez Venturini et al.
Laura de Roch Casagrande et al.
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that requires innovative therapeutic strategies. This is the first study to evaluate the synergistic effects of LIPUS and CUR-AuNPs in an AD model, which ...
Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD [0.03%]
基于四面体框架核酸的针对NAFLD的肝靶向姜黄素递送系统中的适配器介导作用
Shaoyun Chen,Yuchen Liu,Siying Ma et al.
Shaoyun Chen et al.
Curcumin is renowned for anti-inflammatory, antioxidant and hepatoprotective effects, and has been implicated in the amelioration of obesity and diabetes. Notwithstanding its considerable therapeutic potential, the clinical utility of curcu...
Transcranial ultrasound combined with intravenous metformin-loaded oxygenated microbubbles attenuates noise-induced hearing loss in mice [0.03%]
经颅超声联合静脉注射氧合载二甲双胍微气泡减轻噪声性聋小鼠的听力损失
Ai-Ho Liao,Chih-Hung Wang,Lin-Yi Chou et al.
Ai-Ho Liao et al.
Noise-induced hearing loss (NIHL) involves a biphasic pathophysiology. Intense noise exposure causes immediate cochlear vasoconstriction and ischemia, leading to transient hypoxia. Subsequent reperfusion triggers excess reactive oxygen spec...
Oral nanoliposomes functionalized with cRGD and polydopamine for enhanced antimalarial efficacy of disulfide bond-modified dihydroartemisinin prodrug [0.03%]
一种新型DDS：基于石墨相氮化碳纳米片与丝素蛋白的复合抗菌材料
Liqing Chai,Xiaomin Niu,Xiaoning Li et al.
Liqing Chai et al.
Malaria remains a global health crisis, with Plasmodium resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the limitations of oral antimalarials, such as hepatic first-pass metabolism and insufficient...
Metal nanoparticles in cancer theranostics: from synthesis to tumor microenvironment-responsive applications [0.03%]
金属纳米颗粒在癌症诊疗中的应用：从合成到肿瘤微环境响应型应用
Liju Jiang,Ziyu Fu,Baibai Ye et al.
Liju Jiang et al.
Cancer poses a major threat to human health, and conventional treatments (such as surgery, radiotherapy (RT), and chemotherapy) are often associated with significant toxic side effects, poor targeting, and drug resistance. In recent years, ...
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies [0.03%]
核酸编码的抗体基因转移-下一代抗体疗法
Kaikai Yu,Geng Xiao,Baichuan Chen et al.
Kaikai Yu et al.
Antibody therapeutics have emerged as a cornerstone in modern biopharmaceutical development, revolutionizing treatments across diverse diseases. Recent breakthroughs in antibody discovery technologies, particularly single B-cell sorting and...
Transfersomal delivery of Centella asiatica promotes efficient excision wound healing in rats [0.03%]
积雪草转染体传递系统促进大鼠切除伤口高效修复
Sarawut Lapmanee,Phichaporn Bunwatcharaphansakun,Waleewan Phongsupa et al.
Sarawut Lapmanee et al.
This study presents the development and evaluation of Centella Asiatica (CA)-loaded transfersomes (CANP) as a novel nanocarrier for transdermal delivery. CANP were prepared using an oil-in-water emulsion method, producing nanoparticles with...