Mechanics of small intestine motility for oral macromolecular delivery: modelling segmentation versus peristalsis [0.03%]
口服递送大分子药物的小肠运动力学：节段性收缩与蠕动的建模研究
Benyamin Naranjani,Shakhawath Hossain,Marco Tjakra et al.
Benyamin Naranjani et al.
Intestinal motility, including peristalsis and segmentation, drives complex fluid movements critical for the oral delivery of biologics and other macromolecules. Despite advances, oral delivery remains commercially limited by low bioavailab...
Aidin Mohammadi Zonouz,Mehrshad Ebrahimpour,Kimia Zibaei et al.
Aidin Mohammadi Zonouz et al.
Cancer is a complex disease characterized by uncontrolled cell growth and spread, often resulting in metastasis. The use of combination therapy, which involves the simultaneous application of two or more treatment methods, aims to enhance e...
Nanotherapeutics for enhanced treatments for ovarian cancer: a comprehensive minireview [0.03%]
用于增强卵巢癌治疗的纳米药物：全面综述
Xiaotong Xu,Binting Li,Keyi Xu et al.
Xiaotong Xu et al.
As one of the most lethal gynecological malignancies, ovarian cancer (OC) significantly impacts the health and quality of life of women globally. Currently, surgical intervention and chemotherapy remain the primary clinical treatment modali...
Hydrogel-Based intraperitoneal drug delivery platforms for peritoneal metastasis: strategies, advances, and prospects [0.03%]
用于腹膜转移的水凝胶为基础的腹腔药物递送平台：策略、进展和前景
Xianyan Chen,Yuanfeng Wei,Xiaorong Chen et al.
Xianyan Chen et al.
Peritoneal metastasis (PM), as a terminal stage of malignant tumors with extremely poor prognosis, remains a clinical challenge. Intraperitoneal (IP) administration enhances local drug concentrations, improving survival outcomes for PM pati...
Induction of antigen-specific regulatory T cells by engineered extracellular vesicles [0.03%]
工程化细胞外囊泡诱导抗原特异性调节性T细胞
Shota Imai,Kanto Nagamori,Uryo Onishi et al.
Shota Imai et al.
Extracellular vesicles (EVs) are emerging as versatile nanocarriers for targeted drug delivery and immune modulation. However, strategies that can induce antigen-specific immune tolerance remain limited, highlighting an unmet need for more ...
Yu Guo,Min Wang,Yuzhong Zhang et al.
Yu Guo et al.
Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year. Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Although vario...
Nebulized inhalation of novel baicalein liposome based on phospholipid complex to alleviate acute lung injury [0.03%]
基于磷脂复合物的新一代黄芩素吸入用脂质体在急性肺损伤治疗中的应用研究
Zhiyang Wen,Jinghan Yu,Yingying Meng et al.
Zhiyang Wen et al.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are high-mortality respiratory diseases manifested by excessive inflammation and oxidative stress. Current therapies for ALI are limited by uncertain e...
Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy [0.03%]
用于靶向癌症治疗的肿瘤微环境响应型apoA-I模拟肽构象活化
Mengjie Rui,Lei Fang,Mengfei Jia et al.
Mengjie Rui et al.
Apolipoprotein A-I (ApoA-I) mimetic peptides have garnered attention as potential anticancer agents owing to their role in cholesterol metabolism and ability to interact with the SR-BI receptor. However, their tendency to form lipid-bound s...
Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis [0.03%]
无针注射器与胰岛素笔在糖尿病管理中的疗效、安全性及以患者为中心的结果的综合meta分析
Jing Wang,Xinhao Chen,Zhili Ge et al.
Jing Wang et al.
To evaluate the comparative effectiveness, safety, and patient acceptance of needle-free injectors and insulin pens through a meta-analysis. A thorough literature search was performed across multiple databases, including CNKI, the Weipu Dat...
Meta-Analysis
Drug delivery. 2025 Dec 31;32(1):2597906. DOI:10.1080/10717544.2025.2597906 2025