The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity [0.03%]
基于人血清白蛋白的药物递送系统的胶体稳定性对其抑瘤活性有重大影响
Guojun Xiong,Chengwei Jiang,Andreas G Schätzlein et al.
Guojun Xiong et al.
Human serum albumin (HSA) has attracted significant attention in drug delivery since the approval of Abraxane in 2005. Abraxane is a nanoparticle albumin-bound paclitaxel (nab-PTX) formulation. Although HSA offers advantages such as prolong...
Cryopreservation technology for improving the stability of liposomes and its precise drug monitoring in clinical drug research [0.03%]
cryopreservation技术提高liposomes稳定性及其临床药物研究中精准用药监测的作用
George Frimpong Boafo,Ibrahim Shaw,Marlene Davis Ekpo et al.
George Frimpong Boafo et al.
The instability of liposomes in blood samples during clinical drug research and drug monitoring results in the inability to accurately determine the actual drug concentrations in the body at the time of collection, mainly due to lipid deter...
Maria Lummerstorfer,Ulrich Lächelt
Maria Lummerstorfer
CRISPR-Cas9 has revolutionized the field of genome editing. While conventional gene supplementation therapies and the market of related gene therapy products are dominated by viral vectors, non-viral delivery strategies are increasingly bei...
Next-generation composite vesicular systems: an in-depth review of proniosomes in advanced drug delivery [0.03%]
新一代复合囊泡系统：先进药物输送中普尼奥ソーム的深入综述
Jagabandhu Bag,Subhankar Mukhopadhyay,Gouranga Nandi et al.
Jagabandhu Bag et al.
Proniosomes represent an advanced composite vesicular platform that integrates non-ionic surfactants, lipids, and biodegradable carriers to significantly improve drug solubility, stability, and transmembrane delivery. These dry powdery form...
Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis [0.03%]
荧光探针在动脉粥样硬化分子诊断和诊疗中的应用
Xiang Mao,Xia Zhao,Zhigang Ni et al.
Xiang Mao et al.
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, posing a serious threat to human health. Atherosclerosis (AS), the pathological basis of most cardiovascular diseases, is characterized by arterial wall th...
Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of Artocarpus altilis extract [0.03%]
聚乙烯基吡咯烷酮/海藻糖共混电纺纳米纤维敷料促进面包果树提取物的皮肤渗透和抗污染生物活性研究
Chun-Yin Yang,Chih-Hua Tseng,Feng-Lin Yen
Chun-Yin Yang
Artocarpus altilis methanolic extract (AAM) exhibits potent protective effects against particulate matter (PM)-induced skin damage; however, its poor aqueous solubility and limited skin permeability restrict its topical bioavailability. To ...
Cell swelling and upright mounting-based imaging for high-resolution visualization of intracellular trafficking across the BBB using conventional confocal microscopy [0.03%]
细胞肿胀和立式安装基于显微镜成像，使用常规共聚焦显微镜对BBB内吞体转运进行高分辨率可视化研究
Da Hee Oh,Ji Hee Kang,O Hyun Lee et al.
Da Hee Oh et al.
Receptor-mediated transcytosis (RMT) represents a promising strategy for delivering macromolecular and colloidal therapeutics across the blood-brain barrier (BBB). However, mechanistic elucidation of RMT remains limited by the difficulty of...
Long-term management of psoriasis recurrence via modulation of cutaneous microbiome: synergistic topical therapy with blue light and aptamer-functionalized curcumin formulation [0.03%]
利用调制皮肤微生物组的长期复发性银屑病管理：蓝光和功能性阿普塔mer黄酮化合物外用疗法的协同治疗
Nan Jin,Yaling Chen,Huangyu Luo et al.
Nan Jin et al.
The recurrence following the discontinuation of medication is a formidable challenge in managing psoriasis. Changes in the microbiome accompany the onset of psoriasis relapse, highlighting a potential therapeutic modality. To evaluate the s...
Folate-targeted gold nanoparticles for doxorubicin delivery in tumor spheroids [0.03%]
叶酸靶向金纳米颗粒在肿瘤球形细胞中的阿霉素传递研究
Raffaella Daniele,Agnese Fragassi,Cristiano Pesce et al.
Raffaella Daniele et al.
Targeted drug delivery systems represent a promising strategy for enhancing the efficacy and specificity of cancer therapy. In this study, 35 nm folate-targeted gold nanoparticles are presented as nanoparticle-drug conjugates obtained by an...
Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model [0.03%]
一种新型的开胸淋巴管插管清醒猪模型评估口服 Cannabidiol 的淋巴转运性质
Vitalii Rizov,Peter Lukáč,Mikuláš Mlček et al.
Vitalii Rizov et al.
Lymphatic transport of drugs after oral administration is an important physiological process in highly lipophilic compounds, such as cannabidiol (CBD). The majority of lymphatic transport studies have been historically conducted in anesthet...