Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis [0.03%]
线粒体功能障碍及靶向线粒体递送系统在动脉粥样硬化中应用的研究进展
Yanfang Liu,Nan Luo,Xin Xi et al.
Yanfang Liu et al.
Atherosclerosis, a chronic inflammatory disease, is pathologically associated with mitochondrial dysfunction. Mitochondria contribute to oxidative stress, vascular endothelial dysfunction, and chronic inflammatory cascades through pathways ...
A macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury [0.03%]
一种巨噬细胞模拟纳米载体联合载牻牛儿醇和FK13-a1治疗MRSA引起的急性肺损伤
Haonan Li,Binghong Xu,Junguang Liang et al.
Haonan Li et al.
Current clinical strategies for Methicillin-resistant Staphylococcus aureus (MRSA)-induced acute lung injury (ALI) predominantly focus on single-approach interventions such as anti-inflammatory therapy. However, due to the complex, multi-pa...
The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine [0.03%]
基于离子液体及羧基修饰聚乙烯亚胺的DNA递送系统研究与发展
Yaminn Thant,Parin Watcharavongtip,Patumporn Jermsutjarit et al.
Yaminn Thant et al.
Recombinant DNA vaccines offer significant potential for disease prevention and therapy, but their clinical success is often limited by poor immunogenicity, low cellular uptake, instability, and inefficient delivery without proper carriers....
Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions [0.03%]
口服胰岛素给药的再工程化：结构修饰、先进的配方策略和未来方向
Yilin Zheng,Xiaoyi Fang,Jiangtao Gao
Yilin Zheng
Oral insulin delivery represents a transformative approach to diabetes management, offering improved patient compliance and physiological insulin delivery patterns compared to subcutaneous injection. However, multiple gastrointestinal barri...
Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns [0.03%]
介孔硅纳米颗粒的潜力与生物医学应用及安全问题顾虑之间的平衡解锁
Yingze Hou,Can Zhu,Zhean Shen et al.
Yingze Hou et al.
Mesoporous silica nanoparticles (MSNs) have garnered significant attention across various disciplines, including chemistry, physics, and materials science, owing to their distinctive properties and functionalities. Numerous studies have dem...
Yueyou Dai,Dandan Guo,Aifang Li et al.
Yueyou Dai et al.
Currently, increasing attention is being paid to the extraction and utilization of materials with special biological activities in nature or for medical applications. Owing to their unique biological characteristics and diverse application ...
Introducing personalized patient care in overactive bladder management using the MedRing OAB system for intravaginal oxybutynin administration [0.03%]
使用MedRing OAB系统通过宫内 oxybutynin给药介绍个性化护理以管理过度活跃的膀胱
S I Peltenburg,I Koopmans,O Heerema-Snoep et al.
S I Peltenburg et al.
Although numerous drugs have been developed for intravaginal administration, the implementation of personalized intravaginal treatment options is limited. The MedRing overactive bladder (OAB) system is a medical device for intravaginal oxyb...
Advancements and challenges in ophthalmic microneedles to treat eye diseases [0.03%]
眼科微针治疗眼部疾病的进展与挑战
Yongdeok Jo,Chaimae Gouya,William F Mieler et al.
Yongdeok Jo et al.
By 2050, more than 61 million people worldwide are expected to lose their vision due to conditions like age-related macular degeneration, glaucoma, diabetic retinopathy, and uveitis (Bourne et al. 2021). This anticipated rise highlights the...
Development and evaluation of alginate-based gastroretentive raft-forming systems enabling sustained release of propolis in gastric ulcer treatment [0.03%]
一种基于海藻酸盐的胃滞留浮力给药系统用于持续释放蜂胶治疗胃溃疡的研究与评价
Haniye Takbirgou,Maryam Salami,Gholamreza Askari et al.
Haniye Takbirgou et al.
This study aimed to develop alginate-based raft-forming systems incorporating propolis-whey protein isolate (5%) nanocomplexes to alleviate reflux symptoms and enable the sustained, gastric-specific delivery of propolis for ulcer management...