Angiopep-2-decorated bacterial outer membrane vesicles penetrate the blood-brain barrier for glioblastoma chemo-immunotherapy [0.03%]
角蛋白-2装饰的细菌外膜囊泡穿透血脑屏障用于胶质母细胞瘤化疗免疫治疗
Pir Tariq Shah,Zhangrong Lou,Xiaojing Zhu et al.
Pir Tariq Shah et al.
Glioblastoma (GBM) therapy remains one of the most formidable challenges in oncology because of the blood-brain barrier (BBB), immunosuppressive tumor microenvironment, and drug resistance. To overcome these challenges, we designed engineer...
Topical delivery of Mir-497 using cationized gelatin/sodium alginate coacervates for diabetic wound healing [0.03%]
用于糖尿病伤口愈合的阳离子明胶/ sodium alginate共聚物递送Mir-497的研究
Eunmi Ban,Youngun Yu,Yeojin Kim et al.
Eunmi Ban et al.
MicroRNA (miRNA)-based therapeutics are promising for chronic inflammatory diseases, yet their clinical translation is limited by poor stability, inefficient intracellular delivery, and safety concerns. Previously, we reported in vitro anti...
Performance evaluation of an adalimumab biosimilar autoinjector and its reference device: comparative use human factors study in patients with rheumatoid arthritis and juvenile idiopathic arthritis [0.03%]
评估adalimumab相似药自动注射器及其参考设备的性能：一项针对类风湿关节炎和幼年特发性关节炎患者的比较使用的人因学研究
Sam Moses K,Suryaprakash Konda Ramachary Subramanian
Sam Moses K
A Comparative Use Human Factors study was conducted to assess whether the injection success rate (SR) with biosimilar adalimumab-fkjp (Bios-ADA) autoinjector (Hulio®) is comparable to reference adalimumab (Ref-ADA) autoinjector (Humira®),...
Comparative Study
Drug delivery. 2026 Dec 31;33(1):2649991. DOI:10.1080/10717544.2026.2649991 2026
Extracellular payload release from non-internalizing antibody-drug conjugates: mechanisms and linker technologies [0.03%]
非内化抗体药物偶联物的细胞外载荷释放：机制与连接技术
Chenxi Feng,Rui Lou,Shipeng Chen et al.
Chenxi Feng et al.
Antibody‒drug conjugates (ADCs) have taken on a significant role in precision oncology. These molecules, referred to as 'biological missiles', can deliver cytotoxic drugs directly to cancer cells. Traditional ADCs rely on endocytosis and i...
Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease [0.03%]
克服血脑屏障：针对阿尔茨海默病靶向递送和多模式治疗的纳米医学策略
Jiahui Li,Liting Guo,Weiyi Cai et al.
Jiahui Li et al.
Alzheimer's disease (AD) remains a significant therapeutic challenge, primarily because the formidable blood‒brain barrier (BBB), which drastically limits the brain bioavailability of most drugs. Nanoparticle-based drug delivery systems of...
Cerium oxide nanoparticles: antioxidant properties in silicosis treatment and biomedical application prospects-a dialectical consideration [0.03%]
二氧化铈纳米粒子在硅肺治疗中的抗氧化作用及其生物医学应用前景的辩证思考
Ge Ban,Yuanjie Chen,Ran Zhao et al.
Ge Ban et al.
Silicosis is a progressive fibrotic lung disease precipitated by chronic inhalation of crystalline silica. Uptake of silica particles by alveolar macrophages initiates a cascade of persistent inflammation and oxidative stress, in which reac...
Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells [0.03%]
基于适配体的脂质纳米颗粒实现mRNA向CD4+T细胞的靶向递送
Shrey Shah,Meenakshi Ranasinghe,John Decker et al.
Shrey Shah et al.
In vivo genetic engineering of T cells could overcome the logistical, biological, and safety challenges of ex vivo modification, but effective and safe delivery systems remain limited by a lack of cellular specificity. Here, we developed ap...
Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation [0.03%]
破解“不可成药”靶点：溶酶体受体介导的蛋白质降解领域的现状和新兴前沿
Yi-Meng Ma,Hou-Fu Xia,Yi-Lei Xiao et al.
Yi-Meng Ma et al.
Extracellular and membrane-associated proteins are essential in signal transmission, immunological control, and disease pathogenesis; nonetheless, their 'undruggable' characteristics have historically impeded drug discovery. The targeted pr...
ROS-triggerable dual nanocoated probiotics for inflammatory bowel disease treatment [0.03%]
用于治疗炎症性肠病的ROS触发型双重纳米涂层益生菌
Guangze Sang,Sizhen Wang,Qiwei Tai et al.
Guangze Sang et al.
Inflammatory bowel disease (IBD), an immune-mediated chronic gastrointestinal disease, is difficult to treat because its specific pathogenic mechanisms are currently unclear, and its recurrence rate is high. Probiotic therapies have been us...
Genetically engineered M13 phage-mediated H9N2 DNA vaccine with enhanced mucosal and systemic immune responses in mice [0.03%]
一种新型的由转基因M13噬菌体介导的禽流感(H9N2)DNA疫苗及其免疫效果研究
Xiaohua Wang,Zhi Zhao,Mingze Shi et al.
Xiaohua Wang et al.
Vaccine adjuvants and delivery systems have long been used in DNA vaccines to enhance immunogenicity. In this study, we developed a DNA vaccine delivery platform by combining N-2-hydroxypropyl trimethyl ammonium chloride chitosan/carboxymet...