Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy [0.03%]
高效负载PAP-1的聚合物胶束的制备、表征及其抗肿瘤活性评价
Fang Ye,Qi Li,Longping Huang et al.
Fang Ye et al.
The mitochondrial potassium channel Kv1.3 is a critical therapeutic target, as its blockade induces cancer cell apoptosis, highlighting its therapeutic potential. PAP-1, a potent and selective membrane-permeant Kv1.3 inhibitor, faces solubi...
Preparation, quality evaluation and preliminary pharmacokinetic-pharmacodynamic studies of synephrine dry powder inhaler [0.03%]
盐酸派他佐辛干粉吸入剂的制备、质量评价及初步药代药效研究
Jiming Ke,Shenao Li,Miaomiao Zi et al.
Jiming Ke et al.
Acute lung injury (ALI) is a lung disease characterized by pulmonary edema caused by an excessive inflammatory response within the lungs and disruption of the alveolar capillary barrier, with a high morbidity and mortality rate in criticall...
Harnessing nanofibers for targeted delivery of phytoconstituents in age-related macular degeneration [0.03%]
利用纳米纤维靶向递送植物有效成分治疗年龄相关性黄斑变性
Ulia Andrades,Sahil Gaikar,Khushali Nathani et al.
Ulia Andrades et al.
Age-related macular degeneration is a degenerative eye condition that affects the macula and results in central vision loss. Phytoconstituents show great promise in the treatment of AMD. AMD therapy can benefit from the advantages of phytoc...
Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study [0.03%]
评估护士对新型体内药物输送系统与手动注射器给药的偏好：一项调查研究
Mehul Desai,Beth Faiman,Lisa A Gorski et al.
Mehul Desai et al.
While nurses report challenges with the manual administration of large-volume subcutaneous drugs, these challenges and potential solutions are not captured in the literature. In this cross-sectional study, 45 nurses with experience administ...
Comparative Study
Drug delivery. 2025 Dec;32(1):2484278. DOI:10.1080/10717544.2025.2484278 2025
Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist [0.03%]
通过NKG2A靶向递送新型设计的IL-2Rβγ激动剂来调控T/NK细胞用于肿瘤免疫治疗
Jie Chen,Enhui Ren,Ze Tao et al.
Jie Chen et al.
As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust a...
External stimuli-responsive drug delivery to the posterior segment of the eye [0.03%]
对外部刺激响应的眼后段给药系统
Shuting Xu,Yaming Zhang,Jia Li et al.
Shuting Xu et al.
Posterior segment eye diseases represent the leading causes of vision impairment and blindness globally. Current therapies still have notable drawbacks, including the need for frequent invasive injections and the associated risks of severe ...
Exploiting the potential of in situ forming liquid crystals: development and in vitro performance of long-acting depots for peptide drug thymosin alpha 1 subcutaneous administration [0.03%]
利用原位形成液晶的潜力：开发和体外性能评价长期埋植剂用于肽类药物胸腺法新皮下注射
Mercedes Vitek,Alenka Zvonar Pobirk,Robert Roškar et al.
Mercedes Vitek et al.
The fast-growing filed of long-acting depots for subcutaneous (SC) administration holds significant potential to enhance patient adherence to treatment regimens, particularly in the context of chronic diseases. Among them, injectable in sit...
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques [0.03%]
恒河猴新型生物可吸收的阿柏西普药物传递系统的安全性和生物相容性研究
Brett D Story,Sangwan Park,Karolina Roszak et al.
Brett D Story et al.
A clinical need exists for more effective intravitreal (IVT) drug delivery systems (DDS). This study tested the hypothesis that a novel biodegradable, injectable microsphere-hydrogel drug delivery system loaded with aflibercept (aflibercept...
Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia [0.03%]
机器学习辅助设计免疫调节脂质纳米颗粒以递送mRNA并重编程过度活化的小胶质细胞
Mehrnoosh Rafiei,Akbar Shojaei,Ying Chau
Mehrnoosh Rafiei
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid na...
ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound [0.03%]
白蛋白生物大分子集合中ADAMTS5特定的gapmer释放及超声波引发软骨吸收
Marwa Elkhashab,Goncalo Barreto,Maxime Fauconnier et al.
Marwa Elkhashab et al.
Objective: Antisense oligonucleotides (ASOs) have reached the clinic; however, they lack tissue specificity. Albumin is a plasma-abundant macromolecule that has been shown to accumulate in inflamed tissues. In this work, ...