A novel dendrimer-based complex co-modified with cyclic RGD hexapeptide and penetratin for noninvasive targeting and penetration of the ocular posterior segment [0.03%]
一种新的基于树形分子的复合物共修饰环状RGD六肽和穿透蛋白，用于非侵入性靶向和渗透眼部后段组织
Xiucheng Yang,Lihua Wang,Lin Li et al.
Xiucheng Yang et al.
Noninvasive drug delivery is a promising treatment strategy for ocular posterior segment diseases. Many physiological and anatomical barriers of the eye considerably restrict effective diffusion of therapeutics to the target site. To overco...
Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy [0.03%]
一种多功能新型纳米药物用于乳腺癌的联合治疗
Mengna Liu,Bingjie Wang,Chunjing Guo et al.
Mengna Liu et al.
In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive "nano-actiniaes" were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy. The newly synthesi...
Fabrication and characterization of solid lipid nano-formulation of astraxanthin against DMBA-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway [0.03%]
虾青素固体脂质纳米配方的制备与表征及其通过Nrf-2-Keap1和NF-kB以及mTOR/Maf-1/PTEN途径对抗DMBA诱导的乳腺癌作用研究
Tao Sun,Jun Gao,Dan Han et al.
Tao Sun et al.
In the current experimental study, we scrutinized the chemoprotective effect of astraxanthin against the 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway. The double emulsion ...
Evaluation of therapeutic effect of targeting nanobubbles conjugated with NET-1 siRNA by shear wave elastography: an in vivo study of hepatocellular carcinoma bearing mice model [0.03%]
剪切波弹性成像技术评估NET-1靶向siRNA纳米微泡治疗小鼠肝癌的疗效研究
Haitao Shang,Bolin Wu,Xitian Liang et al.
Haitao Shang et al.
This study aimed at investigating the tumor stiffness of hepatocellular carcinoma (HCC) bearing mice model in vivo to evaluate the therapeutic efficacy of targeting nanobubbles (TNBS) conjugated with NET-1 siRNA (NET-1 siRNA-TNBS). Also tes...
Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment [0.03%]
一种新型硝酸毛果芸香碱古尔胶眼部给药系统及其抗青光眼作用研究
Wang Xingqi,Zhang Yong,Li Xing et al.
Wang Xingqi et al.
The objective of this work was to investigate phytantriol-based liquid crystal (LC) gels including cubic (Q2) and hexagonal (H2) phase for ocular delivery of pilocarpine nitrate (PN) to treat glaucoma. The gels were produced by a vortex met...
Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide [0.03%]
基于聚乙烯亚胺的肽修饰脂质纳米粒递送反义寡核苷酸
Shuang Yang,Dandan Wang,Yaojun Sun et al.
Shuang Yang et al.
Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic ...
Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field [0.03%]
磁场作用下使用磁性脂质体增强巨噬细胞向结肠递送
Yusuke Kono,Serika Gogatsubo,Takeshi Ohba et al.
Yusuke Kono et al.
Magnetically guided cell delivery systems would be valuable to achieve effective macrophage-based cell therapy for colonic inflammatory diseases. In the current study, we developed a method for the efficient and simultaneous introduction of...
Electrochemical generation of microbubbles by carbon nanotube interdigital electrodes to increase the permeability and material uptakes of cancer cells [0.03%]
用于提高癌细胞渗透性和物质吸收的碳纳米管叉指电极的微气泡电化学生成技术
Mohammad Ali Khayamian,Shahriar Shalileh,Shohreh Vanaei et al.
Mohammad Ali Khayamian et al.
Artificial cavitation as a prerequisite of sonoporation, plays an important role on the ultrasound (US) assisted drug delivery systems. In this study, we have proposed a new method of microbubble (MB) generation by local electrolysis of the...
Numerical modeling of high-intensity focused ultrasound-mediated intraperitoneal delivery of thermosensitive liposomal doxorubicin for cancer chemotherapy [0.03%]
高强度聚焦超声介导的热敏脂质体制剂区域化内递释药数学模拟研究
Mohsen Rezaeian,Amir Sedaghatkish,M Soltani
Mohsen Rezaeian
Although intraperitoneal chemotherapy (IPC) has been suggested as a promising method for the management of peritoneal dissemination (PD) of ovarian or colorectal cancers, the actual clinical use of this method has been restricted due to suc...
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma [0.03%]
具有高光热转换效率的类血清白蛋白绝缘体氧化纳米平台用于骨肉瘤协同化疗与光热治疗研究
Wenguang Gu,Tao Zhang,Junsheng Gao et al.
Wenguang Gu et al.
Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are succe...