Yitianhe Xu,Kaiying Zhang,Zhanzheng Ye et al.
Yitianhe Xu et al.
Lung cancer is the second most common cancer worldwide, with persistently high morbidity and mortality rates. Despite years of research in the field, a complete cure for this disease remains elusive. Current clinical treatment options prima...
Advances in pH-responsive drug delivery systems for periodontitis treatment [0.03%]
用于牙周炎治疗的pH响应型药物递送系统研究进展
Zhuomin Sha,Yongjia Wu,Yi Zheng et al.
Zhuomin Sha et al.
Periodontitis is a prevalent and destructive inflammatory disease that is closely linked to various systemic conditions. In recent years, the local delivery of therapeutic agents via novel biomaterials has emerged as a promising strategy fo...
Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination [0.03%]
可调节目标细胞鉴别的多价脂质体的价态-亲和力映射关系
Victor A Garcia,Paulina M Eberts,Brenda M Ogle et al.
Victor A Garcia et al.
Multivalency can drive high-avidity binding of ligand-functionalized nanoparticles to cells with high target receptor expression, but it can also contribute to off-target binding to low-expression non-target cells. We explored how ligand af...
Genada Sinani,Sevda Şenel
Genada Sinani
Use of highly purified antigens to improve vaccine safety has led to reduced immunogenicity and efficacy, resulting in the need for adjuvants to increase and/or modulate the immunogenicity of the vaccine. Despite the need for potent and saf...
Targeted treatment of hepatocellular carcinoma with aptamer-guided solid lipid nanoparticles loaded with norcantharidin [0.03%]
白蛋白介导诺絳素固体脂质纳米粒的肝癌靶向治疗研究
Yilin Xu,Min Wang,Jing Wu et al.
Yilin Xu et al.
Liver cancer is a common malignancy in the world, and its incidence and mortality rate are increasing year by year. The disease has a short course and a high mortality rate, posing a serious threat to humanity and health. The objective of t...
Selective expansion and differentiation of antigen-specific CD4+ T-helper cells by engineered extracellular vesicles [0.03%]
工程化细胞外囊泡选择性地扩增并分化抗原特异性CD4⁺T辅助细胞
Ryouken Kimura,Tomoyoshi Yamano,Uryo Onishi et al.
Ryouken Kimura et al.
Extracellular vesicles (EVs), particularly small EVs (sEVs), are lipid bilayer vesicles secreted by various cell types and play a key role in intercellular communication. These vesicles are promising tools for cancer immunotherapy owing to ...
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review [0.03%]
基于壳聚糖的药物递送系统在细菌性疾病治疗中的应用：综述
Huan Huang,Yaxin Zhou,Jiehang Li et al.
Huan Huang et al.
Bacterial diseases are a significant challenge to human and animal health. The current treatment methods still have obvious shortcomings, such as poor targeting, low bioavailability, high side effects and drug resistance. Chitosan, with its...
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management [0.03%]
一种新型乙osomes凝胶制剂，可增强姜黄素和环孢素的经皮传递：类风湿性关节炎管理的临床前方法
Sankalp Gharat,Munira Momin,Urvashi Panchal et al.
Sankalp Gharat et al.
Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (...
Emerging liposomal therapies for diabetic retinopathy: a review of novel targeting approaches and advances in retinal health outcomes [0.03%]
糖尿病视网膜病变的新兴脂质体疗法：新型靶向方法和视网膜健康结果进展的回顾
Ravi Parashar,Preeti K Suresh
Ravi Parashar
Diabetic retinopathy (DR), which affects over millions of individuals globally, is the leading cause of permanent visual loss. Current therapies, including as intravitreal anti-vascular endothelial growth factor (VEGF) medications and laser...
Ophthalmic formulation of methotrexate: a strategy of using the self-assembled LacAC4A nanoparticles for non-invasive drug delivery to the ocular posterior segment [0.03%]
一种新型药物自组装系统用于非侵入性眼内缓释给药体系的研究
Xiao-Yun Hou,Xiao-Ling Zhang,An-Kang Ying et al.
Xiao-Yun Hou et al.
Drug delivery to ocular posterior segment remains difficult due to the challenges imposed by dynamic and static ocular barriers, lesion point targeting, and off-target effect. In this study, a novel approach is demonstrated for non-invasive...