Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity [0.03%]
组蛋白去乙酰化酶活性通过转录沉默作用于活化的的小胶质细胞中的G蛋白信号调节素10（RGS10）表达
Mohammed Alqinyah,Nagini Maganti,Mourad W Ali et al.
Mohammed Alqinyah et al.
RGS10 has emerged as a key regulator of proinflammatory cytokine production in microglia, functioning as an important neuroprotective factor. Although RGS10 is normally expressed in microglia at high levels, expression is silenced in vitro ...
Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland [0.03%]
乳腺细胞和小鼠乳腺中苯并[a]芘代谢及与之相关的DNA加合物形成的昼夜节律调节
Emily E Schmitt,Rola Barhoumi,Richard P Metz et al.
Emily E Schmitt et al.
The circadian clock plays a role in many biologic processes, yet very little is known about its role in metabolism of drugs and carcinogens. The purpose of this study was to define the impact of circadian rhythms on benzo-a-pyrene (BaP) met...
Editor's Note [0.03%]
编者按
Kathryn E Meier
Kathryn E Meier
Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins [0.03%]
丙酮酸脱氢酶激酶4缺乏通过E2F1介导的周期蛋白增加加速细胞增殖
Jonathan Choiniere,Jianguo Wu,Li Wang
Jonathan Choiniere
Hepatocellular carcinoma (HCC) is a common form of cancer with prevalence worldwide. There are many factors that lead to the development and progression of HCC. This study aimed to identify potential new tumor suppressors, examine their fun...
Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells [0.03%]
肿瘤细胞自噬抑制的非自主效应促进耐药细胞生长
Jacqueline Thorburn,Leah Staskiewicz,Megan L Goodall et al.
Jacqueline Thorburn et al.
Autophagy, the mechanism by which cells deliver material to the lysosome, has been associated with resistance to anticancer drugs, leading autophagy inhibition to be widely studied as a potential chemosensitization strategy for cancer cells...
Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy [0.03%]
髓过氧化物酶增强依托泊苷和米托蒽醌介导的DNA损伤：癌症化疗中的髓保护靶点
Mandeep Atwal,Emma L Lishman,Caroline A Austin et al.
Mandeep Atwal et al.
Myeloperoxidase is expressed exclusively in granulocytes and immature myeloid cells and transforms the topoisomerase II (TOP2) poisons etoposide and mitoxantrone to chemical forms that have altered DNA damaging properties. TOP2 poisons are ...
Buprenorphine, Norbuprenorphine, R-Methadone, and S-Methadone Upregulate BCRP/ABCG2 Expression by Activating Aryl Hydrocarbon Receptor in Human Placental Trophoblasts [0.03%]
丁丙诺啡、nor-buprenorphine、R-和S-甲氧基麻精拟人在人胎盘合胞体滋养层细胞中通过激活芳香烃受体上调BCRP/ABCG2表达
Naveen K Neradugomma,Michael Z Liao,Qingcheng Mao
Naveen K Neradugomma
Opioid dependence during pregnancy is a rising concern. Maintaining addicted pregnant women on long-acting opioid receptor agonist is the most common strategy to manage drug abuse in pregnant women. Methadone (MET) and buprenorphine (BUP) a...
Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules [0.03%]
靶向降解亚细胞区室中定位的蛋白质的杂合小分子
Keiichiro Okuhira,Takuji Shoda,Risa Omura et al.
Keiichiro Okuhira et al.
Development of novel small molecules that selectively degrade pathogenic proteins would provide an important advance in targeted therapy. Recently, we have devised a series of hybrid small molecules named SNIPER (specific and nongenetic IAP...
Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway [0.03%]
口服小檗碱通过调节肠道胆汁酸代谢和法尼醇X受体信号途径调控肝脏脂质代谢
Runbin Sun,Na Yang,Bo Kong et al.
Runbin Sun et al.
Previous studies suggest that the lipid-lowering effect of berberine (BBR) involves actions on the low-density lipoprotein receptor and the AMP-activated protein kinase signaling pathways. However, the implication of these mechanisms is unc...