Trimethylamine N-oxide induces macrophage M1 polarization via the Piezo1/Yes-associated protein pathway [0.03%]
通过Piezo1/YAP信号通路诱导巨噬细胞M1极化的三甲胺N氧化物研究
Haiyan Xiang,Congcong Li,Yanhua Tang et al.
Haiyan Xiang et al.
Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been implicated in cardiometabolic inflammation; however, the intracellular signaling mechanisms linking TMAO to macrophage polarization remain incompletely defined. Th...
Ca2+/calmodulin-dependent inhibitors of adenylyl cyclase 1 as novel nonopioid analgesics for chronic inflammatory pain [0.03%]
新型非阿片类钙调神经磷酸酶依赖型腺苷酸环化酶1抑制剂用于慢性炎症痛治疗的潜在价值研究
Tiffany S Dwyer,Annadka Shrinidhi,Sadikshya Aryal et al.
Tiffany S Dwyer et al.
Adenylyl cyclase 1 (AC1) plays an integral role in the excitatory signaling in the anterior cingulate cortex underlying chronic pain pathophysiology. Upon chronic nociceptive input, sustained Ca2+/calmodulin (CaM)-stimulated AC1 activity le...
Expression of concern: "Adelmidrol, a Palmitoylethanolamide Analogue, as a New PharmacologicalTreatment for the Management of Inflammatory Bowel Disease" [Mol. Pharmacol. 2016; 90: 549-561] by Cordaro M, Impellizzeri D, Gugliandolo E, et al [0.03%]
表达关切：“Adelmidrol（棕榈酰乙醇胺类似物）可作为新的药理学治疗药物用于炎症性肠病的管理”[Mol. Pharmacol. 2016; 90: 549-561] Cordaro M, Impellizzeri D, Gugliandolo E, 等人
Expression of concern: "Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related (GITR)-Fc Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response after Spinal Cord Injury" [Mol. Pharmacol. 2008; 73: 1610-1621] by Nocentini G, Cuzzocrea S, Genovese T, et al [0.03%]
表达关切：“糖皮质激素诱导的肿瘤坏死因子受体相关(GITR)-Fc融合蛋白抑制GITR触发并保护脊髓损伤后的炎症反应”[Mol. Pharmacol. 2008;73:1610-1621]
Expression of concern: "The Cyclopentenone Prostaglandin 15-Deoxy-delta12,14-Prostaglandin J2 Attenuates the Development of Acute and Chronic Inflammation" [Mol. Pharmacol. 2002; 61: 997-1007] by Cuzzocrea S, Wayman N, Mazzon E, et al [0.03%]
表达关注：“环戊烯酮前列腺素15-脱氧精胺缩氨硫酶12,14-前列腺素J2可减轻急性炎症和慢性炎症的发展”[Mol. Pharmacol. 2002; 61: 997-1007]
Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor [0.03%]
细胞内环2区的稀有变异改变生长激素释放肽受体的空间分布和转导偶联选择性
Elsa M Balfe,Alexandre Torbey,Tomasz M Stepniewski et al.
Elsa M Balfe et al.
G protein-coupled receptors (GPCRs) are the largest class of membrane proteins and the most common pharmaceutical drug target. Prior work from our group and others supports that a conserved, proline-hydrophobic residue (ProH) motif within i...
Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6 [0.03%]
探究Sunitinib和Sorafenib与细胞色素P450酶CYP2U1和CYP2D6的结合及代谢相互作用机制
Tiffany Y-C Tang,Yupeng Li,Peter Chapman et al.
Tiffany Y-C Tang et al.
Cytochrome P450 2U1 (CYP2U1) is an extrahepatic monooxygenase that metabolizes both endogenous fatty acids and xenobiotic substrates. Because of its high expression in both healthy and cancerous thymus tissues, this study investigated CYP2U...
Beverley Greenwood-Van Meerveld,John Tesmer,Michael Jarvis
Beverley Greenwood-Van Meerveld
Corrigendum to "A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor" [Molecular Pharmacology 108 (2026) 100104] [0.03%]
"Molecular Pharmacology期刊中关于GluN1/GluN3A甘氨酸激活受体亚单位选择性负向别构调节剂的更正文章（卷期：108，页码：100104）"
Leon Jacobs,TrangKimberly T Nguyen,Adam McCallum et al.
Leon Jacobs et al.
Published Erratum
Molecular pharmacology. 2026 Mar 30;108(4):100118. DOI:10.1016/j.molpha.2026.100118 2026
Identification of potential autophagy inducers through high-throughput and high-content imaging analysis [0.03%]
基于高通量和高内涵成像分析的潜在自噬诱导剂筛选
Masato Ooka,Leah Mitchell,Jinghua Zhao et al.
Masato Ooka et al.
Autophagy is a cellular degradation process that plays a critical role in maintaining homeostasis and preventing stress-induced damage, making it a promising therapeutic target for cancer and neurodegenerative diseases. In this study, we ut...