An integrated structural and functional profiling approach uncovers the mechanisms of pregnane X receptor binding and activation by pharmaceutical and environmental compounds [0.03%]
一种整合结构和功能特征分析方法揭示药物及环境化合物与孕烷X受体结合及其激活机制
Quentin Derosa,Coralie Carivenc,Savannah Sirounian et al.
Quentin Derosa et al.
The pregnane X receptor (PXR) is a key chemosensory protein that helps the organism adapt to its chemical environment. Indeed, humans are continuously exposed to a wide range of external chemicals, known as xenobiotics, which include enviro...
Anchored kinase and phosphatase signaling networks in amyloid β-induced synaptic dysfunction [0.03%]
Tau锚定的蛋白激酶和磷酸酶信号网络在淀粉样蛋白诱导的突触功能障碍中的作用
Laura Koek,Ha-Neul Jo,Matthew J Kennedy et al.
Laura Koek et al.
Impaired excitatory synaptic function and synapse loss are early hallmarks of Alzheimer's disease (AD). There is strong biochemical, genetic, physiological, and anatomical evidence that the accumulation of soluble amyloid beta (Aβ) oligome...
Alexey I Kuzmenkov,Alexander A Vassilevski
Alexey I Kuzmenkov
Potassium (K+) channels are targeted by a wide range of chemical and biological substances, with peptide ligands standing out due to their exceptional affinity and selectivity. Although most of these molecules belong to venom-derived compou...
Regulation of organic anion transporting polypeptide 1B1 transport function by lysine deacetylase 6 [0.03%]
乙酰化酶KAT6A调控有机阴离子转运多肽OATP1B1的功能及介导药物相互作用
Vikram Aditya,Vishakha Tambe,Pascaline Niyonshuti et al.
Vikram Aditya et al.
Hepatic transport protein organic anion transporting polypeptide 1B1 (OATP1B1) is a key determinant of drug-drug interactions. We reported OATP1B1 lysine acetylation recently, however, the lysine deacetylase (KDAC), also known as histone de...
Neuroprotective in vitro effects of histone deacetylase 6-selective inhibitor SW-100 toward oxaliplatin-derived toxicity [0.03%]
组蛋白去乙酰酶6选择性抑制剂SW-100对抗奥沙利铂诱发神经毒性的体内神经保护作用
Angelica Squarzoni,Arianna Scuteri,Elisabetta Donzelli et al.
Angelica Squarzoni et al.
Chemotherapy-induced peripheral neuropathy is a common side effect of chemotherapy drugs. Currently, no effective preventive strategies or treatments are available. In recent years, histone deacetylase inhibitors (HDACis), initially approve...
Emerging roles of platelet DNA in cancer detection and noninvasive prenatal testing [0.03%]
血小板DNA在癌症检测和无创产前诊断中的新作用
Manli Ding,Xiaohui Huang,Xueqian Ouyang et al.
Manli Ding et al.
Cell-free DNA (cfDNA) level is a core liquid biopsy biomarker. However, it exhibits low detection sensitivity in early-stage diseases and carries a risk of information loss. Traditionally regarded as anucleate and DNA-deficient, platelets h...
Binding affinities for histamine receptors 1 to 4: Systematic comparison of ligands from the Psychoactive Drug Screening Program Ki database and International Union of Basic and Clinical Pharmacology/British Pharmacological Society Guide to Pharmacology [0.03%]
组胺受体1-4结合亲和力：来自精神活性药物筛选计划Ki数据库与国际药理学基础与临床委员会/英国药理学会药物指南的配体的系统比较
Lilly Josephine Bindel,Roland Seifert
Lilly Josephine Bindel
Histamine receptors (H1R-H4R) are G protein-coupled receptors with large physiological and therapeutic relevance. Despite extensive research, a systematic and cross-database overview of ligands is missing. This review integrates the Psychoa...
Molecular pharmacology of mGlu7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators [0.03%]
mGlu7/8异二聚体的分子药理学揭示了正向别构调节剂的独特性质 Ortosteric激动剂和阳性别构调质的独特性质
Anthony S Ferranti,Youhyun Noh,Xia Lei et al.
Anthony S Ferranti et al.
The metabotropic glutamate (mGlu) receptors are family C G protein-coupled receptors that are widely expressed throughout the central nervous system and function as either homodimers or heterodimers. Recent literature suggests that specific...
Effects of ivermectin on the activation and desensitization of the human GABAA receptor [0.03%]
伊维菌素对人GABAA受体激活和脱敏的影响
Spencer R Pierce,Allison L Germann,Ka Tak Tsoi et al.
Spencer R Pierce et al.
Ivermectin (IVM) is a widely used antiparasitic drug that acts through allosteric activation and potentiation of the glutamate-gated chloride channel present in neurons and muscle cells of helminths and insects. In mammals, IVM activates se...
Corrigendum to "Amantadine derivative Amt-1 enhances antiviral defense against influenza A virus via Nrf2/HO-1 pathway" [Molecular Pharmacology 108 (2026) 100099] [0.03%]
“氨茶碱衍生物Amt-1通过Nrf2/HO-1通路增强对甲型流感病毒的抗病毒防御”的勘误页[Molecular Pharmacology 108 (2026) 100099]
Shixin Li,Jingyan Wei,Shaofen Zhou et al.
Shixin Li et al.
Published Erratum
Molecular pharmacology. 2026 Jun 13;108(5-6):100136. DOI:10.1016/j.molpha.2026.100136 2026