Correction to "Antibody Tracking Demonstrates Cell Type-Specific and Ligand-Independent Internalization of Guanylyl Cyclase A and Natriuretic Peptide Receptor C" [0.03%]
关于“抗体追踪证明鸟苷酸环化酶A和利钠肽受体C的细胞类型特异性及配体非依赖性内吞作用”的勘误通知
Published Erratum
Molecular pharmacology. 2017 Feb;91(2):157. DOI:10.1124/mol.111.070573err 2017
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay [0.03%]
基于NanoLuc的蛋白质片段互补筛选出MYC相互作用蛋白AKT1、LKB1和YAP1
Xiulei Mo,Qi Qi,Andrei A Ivanov et al.
Xiulei Mo et al.
The c-Myc (MYC) transcription factor is a major cancer driver and a well-validated therapeutic target. However, directly targeting MYC has been challenging. Thus, identifying proteins that interact with and regulate MYC may provide alternat...
Trim13 Potentiates Toll-Like Receptor 2-Mediated Nuclear Factor κ B Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6 [0.03%]
通过K29连接的肿瘤坏死因子受体相关因子6多泛素化，Trim13增强 Toll样受体2介导的核因子κ B活化
Bin Huang,Suk-Hwan Baek
Bin Huang
Ubiquitination is a versatile post-translational modification involved in nuclear factor-κB (NF-κB) activation of Toll-like receptor (TLR) signaling. Here, we demonstrated that Trim13, an E3 ubiquitin ligase, is up-regulated in macrophage...
Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics [0.03%]
一种新型肝X受体激动剂的鉴定及其通过具有不同药理学特征调节关键胆固醇稳态基因表达的作用
Ni Li,Xiao Wang,Yanni Xu et al.
Ni Li et al.
Activation of liver X receptor (LXR) is associated with cholesterol metabolism and anti-inflammatory processes, which makes it beneficial to antiatherosclerosis therapy. Nevertheless, existing agonists that target LXR, for example TO901317,...
Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention [0.03%]
胆固醇调节趋化因子受体功能：药物干预的新思路
Daniel F Legler,Christoph Matti,Julia M Laufer et al.
Daniel F Legler et al.
Chemokine receptors are seven transmembrane-domain receptors belonging to class A of G-protein-coupled receptors (GPCRs). The receptors together with their chemokine ligands constitute the chemokine system, which is essential for directing ...
Protein Kinase C Activation Promotes α1B-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization [0.03%]
蛋白激酶C活化通过Rab9作用促进α1B-肾上腺素受体的内吞和晚期内体转运：在异源脱敏中的作用
Marco A Alfonzo-Méndez,David A Hernández-Espinosa,Gabriel Carmona-Rosas et al.
Marco A Alfonzo-Méndez et al.
Upon agonist stimulation, α1B-adrenergic receptors couple to Gq proteins, calcium signaling and protein kinase C activation; subsequently, the receptors are phosphorylated, desensitized, and internalized. Internalization seems to involve s...
Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function [0.03%]
亚单位界面对α9α10烟碱型乙酰胆碱受体功能的差异化贡献
Juan Carlos Boffi,Irina Marcovich,JasKiran K Gill-Thind et al.
Juan Carlos Boffi et al.
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a p...
Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling [0.03%]
布鲁顿酪氨酸激酶抑制剂捕获Y551残基和阻止其磷酸化以区分Fc受体与B细胞受体信号转导的抑制效力的能力
Andrew T Bender,Anna Gardberg,Albertina Pereira et al.
Andrew T Bender et al.
Bruton's tyrosine kinase (Btk) is expressed in a variety of hematopoietic cells. Btk has been demonstrated to regulate signaling downstream of the B-cell receptor (BCR), Fc receptors (FcRs), and toll-like receptors. It has become an attract...
Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase [0.03%]
三亚唑双膦酸酯烯烃异构体协同抑制焦磷酸古洛糖酯合成酶
Cheryl Allen,Sandhya Kortagere,Huaxiang Tong et al.
Cheryl Allen et al.
The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate. GGDPS inhibition ...
Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism [0.03%]
UGT1A选择性剪接变异体与结肠癌细胞代谢之间的互作关系
Yannick Audet-Delage,Michèle Rouleau,Mélanie Rouleau et al.
Yannick Audet-Delage et al.
Alternative splicing at the human glucuronosyltransferase 1 gene locus (UGT1) produces alternate isoforms UGT1A_i2s that control glucuronidation activity through protein-protein interactions. Here, we hypothesized that UGT1A_i2s function as...