Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5 [0.03%]
Gedunin和Khivorin衍生物是粘附G蛋白偶联受体GPR56/ADGRG1和GPR114/ADGRG5的的小分子部分激动剂
Hannah M Stoveken,Scott D Larsen,Alan V Smrcka et al.
Hannah M Stoveken et al.
Adhesion G protein-coupled receptors (aGPCRs) have emerged as potential therapeutic targets in multiple cancers and in neurologic diseases. However, there are few modulatory compounds that act on these receptors. The majority of aGPCRs are ...
CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins [0.03%]
视黄醇羟化酶CYP26C1与细胞内视黄酸结合蛋白的相互作用
Guo Zhong,David Ortiz,Alex Zelter et al.
Guo Zhong et al.
The clearance of retinoic acid (RA) and its metabolites is believed to be regulated by the CYP26 enzymes, but the specific roles of CYP26A1, CYP26B1, and CYP26C1 in clearing active vitamin A metabolites have not been defined. The goal of th...
Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin [0.03%]
谷胱甘肽修饰的双核二硝基铁络合物的心血管效应：一氧化氮合物生成及血浆白蛋白调节作用的证据
Taiming Liu,Meijuan Zhang,Michael H Terry et al.
Taiming Liu et al.
Glutathione-liganded binuclear dinitrosyl iron complex (glut-BDNIC) has been proposed to be a donor of nitric oxide (NO). This study was undertaken to investigate the mechanisms of vasoactivity, systemic hemodynamic effects, and pharmacokin...
Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons [0.03%]
乙醇对背根神经节神经元氧可酮耐受的逆转作用
Joanna C Jacob,Kensuke Sakakibara,Ryan A Mischel et al.
Joanna C Jacob et al.
Oxycodone is a semisynthetic opioid compound that is widely prescribed, used, and abused today, and has a well-established role in shaping the current opioid epidemic. Previously, we have shown that tolerance develops to the antinociceptive...
Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs [0.03%]
壳聚糖-视网膜共轭体能有效将活性光敏剂递送至盲鼠和犬的视网膜感光细胞中
Songqi Gao,Shirin Kahremany,Jianye Zhang et al.
Songqi Gao et al.
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the visual chromophore 11-cis-retinal and sustain vision. Genetic or environmental factors affecting chromophore production can lead to blindness...
High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors [0.03%]
高固有活性可以解释突变型GABAA受体的直接激活增强和诱导减弱的结合现象
Allison L Germann,Daniel J Shin,Christina R Kuhrau et al.
Allison L Germann et al.
GABAA receptors activated by the transmitter GABA are potentiated by several allosterically acting drugs, including the intravenous anesthetic propofol. Propofol can also directly activate the receptor, albeit at higher concentrations. Prev...
G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor [0.03%]
G蛋白预组装可挽救W6.48转换突变在神经肽Y2受体上的活性
Anette Kaiser,Caroline Hempel,Lizzy Wanka et al.
Anette Kaiser et al.
Ligand binding and pathway-specific activation of G protein-coupled receptors is currently being studied with great effort. Individual answers may depend on the nature of the ligands and the effector pathway. Recently, we have presented a d...
Allosterism within δ Opioid- κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy [0.03%]
外周感觉神经元δ阿片受体与κ阿片受体异源二聚体内别构调节作用：对κ阿片激动剂效能的影响
Blaine A Jacobs,Miryam M Pando,Elaine Jennings et al.
Blaine A Jacobs et al.
There is abundant evidence for formation of G protein-coupled receptor heteromers in heterologous expression systems, but little is known of the function of heteromers in native systems. Heteromers of δ and κ opioid receptors (DOR-KOR het...
Long Noncoding RNA LINC00657 Acting as a miR-590-3p Sponge to Facilitate Low Concentration Oxidized Low-Density Lipoprotein-Induced Angiogenesis [0.03%]
长链非编码RNA LINC00657通过充当miR-590-3p海绵来促进低浓度氧化型低密度脂蛋白诱导的血管生成
Mei-Hua Bao,Guang-Yi Li,Xiao-Shan Huang et al.
Mei-Hua Bao et al.
Angiogenesis in atherosclerotic plaque promotes plaque growth, causes plaque hemorrhage, and violates plaque stability. LINC00657 is a long noncoding RNA highly conserved and abundantly expressed in vascular endothelial cells. The present s...
Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme [0.03%]
人和异源二聚化的血管紧张素转换酶机制研究
J Albert Abrie,Wessel J A Moolman,Gyles E Cozier et al.
J Albert Abrie et al.
Angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system (RAS), which is primarily responsible for blood pressure homeostasis. Studies have shown that ACE inhibitors yield cardiovascular benefits that cannot ...