Corrigendum to "Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects" [Molecular Pharmacology 107 (2025) 100055] [0.03%]
关于“clobenprobit与CXCR4的结合模式研究及开发新型抗炎化合物（具有增强活性和最小拮抗作用）”的勘误[Molecular Pharmacology 107 (2025) 100055]的更正公告
Birgit Caspar,Nassima Bekaddour,Séverine Grinberg et al.
Birgit Caspar et al.
Published Erratum
Molecular pharmacology. 2025 Sep 16;107(10):100071. DOI:10.1016/j.molpha.2025.100071 2025
Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule Na+/taurocholate co-transporting polypeptide is essential for virus entry [0.03%]
乙型肝炎病毒preS1表面肽与细胞受体Na+/牛脱氧胆酸盐共转运多肽相互作用对其感染的必要性
Sebastian Kunz,Lena Soppa,Regina Leidolf et al.
Sebastian Kunz et al.
The myristoylated preS1 domain (myr-preS1) of the hepatitis B virus (HBV) large surface protein is essential for binding to the receptor protein, Na+/taurocholate co-transporting polypeptide (NTCP), and for the subsequent internalization of...
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway [0.03%]
异质性核糖核蛋白A/B通过Akt-GSK3β-Wnt途径驱动胃癌和上皮间充质转化
Luo Huiru,Aime Gael Yaya Traore,Junyi Hu et al.
Luo Huiru et al.
Gastric cancer (GC) is a leading cause of cancer-related deaths globally, with metastasis critically impacting prognosis. Splicing factors are key regulators of tumorigenesis, particularly in metastasis. In this exploratory study, we invest...
A machine learning-based analysis method for small molecule high content screening of three-dimensional cancer spheroid morphology [0.03%]
基于机器学习的三维癌细胞球体形态的小分子高内涵筛选分析方法研究
Vishakha Goyal,Dvir Blivis,Steven A Titus et al.
Vishakha Goyal et al.
Although multiparameter cellular morphological profiling methods and three-dimensional (3D) biological model systems can potentially provide complex insights for pharmaceutical discovery campaigns, there have been relatively few reports com...
Pirin does not bind to p65 or regulate NFκB-dependent gene expression but does modulate cellular quercetin levels [0.03%]
Pirin 不与p65结合或调节NFκB依赖性基因表达但可调节细胞中的槲皮素水平
Melissa Meschkewitz,Erika M Lisabeth,Denaly Anna Cab Gomez et al.
Melissa Meschkewitz et al.
Pirin is a nonheme iron-binding protein with a variety of proposed functions, including serving as a coactivator of p65 NFκB and quercetinase activity. We report here, failure to confirm pirin's primary proposed mechanism, binding of Fe(II...
Biasing G protein βγ subunit downstream signaling enhances the analgesic effects of endogenous opioid receptor agonists during nitroglycerin-induced thermal hypersensitivity [0.03%]
偏置G蛋白βγ下游信号增强内源性阿片受体激动剂在硝酸甘油诱导的热过敏中的镇痛作用
Farzanna A Mohamed,Alan V Smrcka,Emily M Jutkiewicz
Farzanna A Mohamed
μ-Opioid receptor (MOR) agonists are a mainstay in acute pain management. However, they also produce adverse effects and are frequently misused, increasing susceptibility for opioid use disorder. Thus, a strategy for improving the safety o...
Liver CYP4A autophagic lysosomal degradation: A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site [0.03%]
肝CYP4A自噬溶酶体降解：通过不常见的靶点相互作用位点，自噬受体SQSTM1 / p62发挥重要作用
Liang He,Doyoung Kwon,Michael J Trnka et al.
Liang He et al.
The hepatic P450 hemoproteins CYPs 4A are typical N-terminally anchored type I endoplasmic reticulum (ER) proteins, inducible by many hypolipidemic drugs and peroxisome proliferators. They are engaged in the ω-/ω-1-oxidation of various fa...
Trace amine-associated receptor 1 agonists differentially regulate dopamine transporter function [0.03%]
踪胺相关受体1激动剂不同调节多巴胺转运蛋白功能
Julia K Huey,Xiao Shi,William E Schutzer et al.
Julia K Huey et al.
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor stimulated by trace amines and amphetamine-like psychostimulants. The TAAR1 agonists RO5166017 and RO5256390 have antidepressant- and anxiolytic-like effects in precl...
Metabotropic glutamate receptor homo- and heterodimers exhibit distinct responses to orthosteric and allosteric ligands [0.03%]
代谢型谷氨酸受体同源和异源二聚体与正构和变构配体的作用反应不同
Tyler W McCullock,Tyler Couch,Paul J Kammermeier
Tyler W McCullock
Metabotropic glutamate receptors (mGlus) are obligate dimer G protein-coupled receptors that can all homodimerize and heterodimerize in select combinations. Responses of mGlu heterodimers to selective ligands, including orthosteric agonists...
The peroxisome proliferator-activated receptor α/β/γ agonist NCPC-626 from microbial metabolites alleviates metabolic dysfunction-associated steatohepatitis in mice [0.03%]
由微生物代谢产物的过氧化物酶体增殖激活受体α/β/γ激动剂NCPC-626缓解小鼠与代谢紊乱相关的steatohepatitis
Man Yu,Xiao Ren,Ruolan Li et al.
Man Yu et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease characterized by steatosis, inflammatory responses, and fibrosis. Peroxisome proliferator-activated receptors (PPARs), master regulators of glucolipid ho...