Moving beyond shock: Rich-lean transition procedures as a modern approach to anxiolytic screening [0.03%]
超越惊跳反射：富集-稀释过渡程序作为抗焦虑筛选的现代方法
Mia I Rough,Julia L Kratzenberg
Mia I Rough
Selective serotonin reuptake inhibitor fluoxetine, reduces solid tumor burden and metastasis through activation of host antitumor immune response and modulation of tumor microenvironment [0.03%]
选择性五羟色胺再摄取抑制剂氟西汀通过激活宿主抗肿瘤免疫反应并调节肿瘤微环境来减少实体瘤负荷和转移
Krishna Mahanti,Jayasree Saha,Pallabi Mondal et al.
Krishna Mahanti et al.
The tumor microenvironment (TME) plays a pivotal role in tumorigenesis, metastasis, and resistance to therapy. Although immunotherapeutic approaches such as CAR-T cells, immune checkpoint inhibitors, and tumor vaccines have demonstrated pro...
Flavorants enhance nicotine vapor self-administration in diet-induced obese female mice [0.03%]
香料增强饮食诱导的肥胖雌性小鼠自我吸入尼古丁蒸汽的行为
Samuel Tetteh-Quarshie,Esther N Mensah,Dasheya M Booker et al.
Samuel Tetteh-Quarshie et al.
Nicotine dependence and obesity are global health issues. Emerging studies suggest that obese individuals are more likely to develop nicotine dependence. Despite this knowledge, there have been few investigations into whether nicotine dose ...
Empagliflozin mitigates doxorubicin-induced nephrotoxicity by modulating sirtuin 1, nuclear factor-κB/tumor necrosis factor-α, and cleaved caspase-3 pathways without compromising its cytotoxic efficacy [0.03%]
恩格列净通过调节沉默信息调节因子1、核因子-κB/肿瘤坏死因子-α和裂解型半胱天冬酶-3信号通路缓解多柔比星诱导的肾毒性且不降低其细胞毒效应
Amna G Tawfik,Heba A Habib,Esraa M Zeidan et al.
Amna G Tawfik et al.
Doxorubicin (DOX), an anthracycline antibiotic, is a first-line chemotherapy drug for managing various tumors. Its hazards, particularly nephrotoxicity, complicate its clinical application. Empagliflozin (EMPA), an antidiabetic drug inhibit...
Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor [0.03%]
硫酸希那替莫（TAK-935）是一种新型胆固醇24-羟化酶抑制剂，本研究对其药代动力学、酶占有率和药效学进行了临床前表征
Maki Miyamoto,Toshiya Nishi,Tatsuki Koike et al.
Maki Miyamoto et al.
The conversion of cholesterol to 24S-hydroxycholesterol (24HC) is a brain-specific reaction catalyzed by cholesterol 24-hydroxylase (CH24H). Soticlestat, a specific inhibitor of CH24H, has the potential to reduce 24HC levels in the brain; 2...
Effects of specialized proresolving mediators on gut epithelial barrier in early life [0.03%]
专业解决介质对生命早期肠道上皮屏障的影响
Jing Chen,Sarah Ouahoud,Renee R C E Schreurs et al.
Jing Chen et al.
Damage to the intestinal epithelial barrier is a hallmark of inflammatory diseases such as necrotizing enterocolitis. Specialized proresolving mediators (SPMs), such as lipoxin A4, resolvin D1, and resolvin E1, which are derived from essent...
iRhom2 deletion protects against diabetic neuropathy by suppressing neuroinflammation [0.03%]
通过抑制神经炎症保护糖尿病神经病变的iRhom2缺失作用机制研究
Vitoria Mattos Pereira,Isabelle Dove Wasseen,Zhaojie Zhang et al.
Vitoria Mattos Pereira et al.
Diabetic peripheral neuropathy (DPN) is a major complication of diabetes, characterized by progressive nerve damage and debilitating pain. Neuroinflammation plays a critical role in its pathogenesis, but therapeutic options remain limited. ...
Inhalable iguratimod-loaded nanostructured lipid carriers for asthma-chronic obstructive pulmonary disease overlap management [0.03%]
用于哮喘-慢性阻塞性肺病重叠综合管理的可吸入iguratimod纳米结构脂质载体
Sayak Khawas,Neelima Sharma
Sayak Khawas
Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a chronic inflammatory airway condition that presents with features of both asthma and COPD, complicating its treatment and management. In this study, the potential of igu...
Screening of anticancer drugs against potential carcinogenic bacterial virulence proteins in colorectal cancer: An in silico approach [0.03%]
结直肠癌潜在致癌细菌毒力蛋白的抗肿瘤药物筛选：一种基于计算的方法
Vaijayanthi Saravanan,Vinoj Gopalakrishnan,Maria Infant Majula Shifani Mahendran et al.
Vaijayanthi Saravanan et al.
Anaerobic bacteria induced colorectal cancer (CRC) represents a significant clinical concern. The understanding of cancer etiology has evolved significantly, from being predominantly viewed as genetically induced cancer to bacterial biofilm...
Alternative reinforcement reduces oxycodone self-administration in male and female monkeys: Implications for treating opioid use disorder [0.03%]
替代增强可减少雄性和雌性猴子自发放置羟考酮的行为：对治疗阿片类物质使用障碍的启示
Carly Baehr,Andrew C Harris
Carly Baehr