Safety, pharmacodynamics, and pharmacokinetics of oral cannabigerol in healthy adults [0.03%]
口服麻椒素在健康成人中的安全性、药代动力学和药效学研究
David Wolinsky,Dhathri Srungaram,Alec Zhang et al.
David Wolinsky et al.
Cannabigerol (CBG) is a minor cannabinoid that has been considered as a potential therapeutic, yet basic acute pharmacodynamics and pharmacokinetics across commercially available doses have not been examined. To complete this critical step,...
Computational pharmacology and in silico clinical trials for the development of drugs from natural products: A review of advances, opportunities, and challenges [0.03%]
计算药理学和计算机临床试验在天然产物药物开发中的应用：进展、机遇与挑战综述
Chinonyelum Emmanuel Agbo,Chinemelum Kingsley Nwankwo,Jennifer Chinaecherem Onyehalu et al.
Chinonyelum Emmanuel Agbo et al.
Natural products have inspired the discovery of several drug candidates and US Food and Drug Administration-approved drugs. However, the conventional drug development pathway has several limitations, necessitating innovative strategies. Com...
PF5190457 reduces fentanyl intake and seeking with a low risk pharmacological profile in male rats [0.03%]
新型给药拮抗剂 PF5190457 对雄性大鼠芬太尼摄入和觅药行为的影响及低风险的药理学特性
Christina R Merritt,Leah M Salinsky,Erik J Garcia et al.
Christina R Merritt et al.
The opioid epidemic remains a persistent public health challenge in the United States, leaving many people affected by or vulnerable to opioid use disorder (OUD). Although US Food and Drug Administration-approved medications for OUD improve...
Cardiac homing peptide-decorated epigallocatechin gallate-loaded poly(lactic-co-glycolic acid) nanoparticles alleviate acute myocardial infarction [0.03%]
负载表没食子儿茶素-3- gallate的的心肌靶向多聚(lactic-co-glycolic acid)纳米粒缓解急性心肌梗死症状
Haiqi Li,Ruohui Huang,Jinhong Zhang et al.
Haiqi Li et al.
Epigallocatechin gallate (EGCG) exerts cardioprotective effects on acute myocardial infarction through multiple pathways. However, the clinical application of EGCG is limited because of its instability under physiological conditions and low...
M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer's pathophysiology in APPswe/PSEN1ΔE9 mice [0.03%]
APPSwe/PSEN1ΔE9小鼠中M1胆碱能受体调节引起阿尔茨海默病病理生理学的性别差异改变
Wesam Bassiouni,Emily Ye,Tash-Lynn L Colson et al.
Wesam Bassiouni et al.
Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline, where females account for 60% of diagnosed cases. AD is featured by β-amyloid deposition, which influences the activity of M1 muscarinic acetylcholine re...
Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model [0.03%]
阻断白介素-33可减少联合型胶原诱导性关节炎-吸入内毒素暴露模型的关节、全身和肺部炎症反应
Jill A Poole,Jacob L Larsen,Geoffrey M Thiele et al.
Jill A Poole et al.
Therapies capable of resolving rheumatoid arthritis (RA)-associated lung disease, particularly in the setting of environmental exposures, are lacking. This study sought to determine whether blocking interleukin (IL)-33 in a murine model of ...
Keeping it acid ceramidase: How adiponectin protects in the glomerulus [0.03%]
保持酸性鞘氨醇胺酶活性：脂联素如何在肾小球中发挥保护作用
Noelle I Frambes,Erin B Taylor,Jennifer C Sullivan et al.
Noelle I Frambes et al.
Preclinical pharmacology of N-pyrrolidino "nitazene" opioids appearing in nonmedical drug markets [0.03%]
在非医药市场出现的N-吡咯烷基“尼塔津类”阿片类药物的临床前药理学研究
Grant C Glatfelter,Alexander D Maitland,Nicholas R Gonzalez et al.
Grant C Glatfelter et al.
N-pyrrolidino (PYR) nitazenes are a subset of 2-benzylbenzimidazole opioids appearing in illicit drug markets, but there is limited information about the pharmacology of these compounds. Here, we examined the opioid-like effects of PYR nita...
α-Synuclein regulates monoamine transporter capacity and amphetamine-induced efflux via modulation of transporter expression [0.03%]
α-突触核蛋白通过调节转运体的表达来调控单胺转运体容量及安非他明诱导的释放作用
Iina Ludwig,Samuel Moser,Marina Lukenic et al.
Iina Ludwig et al.
α-Synuclein (α-syn) is a presynaptic protein implicated in Parkinson disease and related synucleinopathies, but its physiological function remains incompletely understood. Monoamine transporters, including the dopamine transporter (DAT) a...
Bronchorelaxant and anti-inflammatory profile of ensifentrine alone and combined with inhaled medications in lipopolysaccharide-challenged human airways from chronic obstructive pulmonary disease donors [0.03%]
源自慢性阻塞性肺病供者的气道内LPS刺激后，恩昔芬特单药和联合吸入药物的支气管舒张作用及抗炎特性
Luigino Calzetta,Tara Rheault,Shima Gholamalishahi et al.
Luigino Calzetta et al.
The ENHANCE trials demonstrated that ensifentrine (CAS Number 1884461-72-6), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor, offers additional benefits in chronic obstructive pulmonary disease (COPD). Its bifunctional activity warran...