M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer's pathophysiology in APPswe/PSEN1ΔE9 mice [0.03%]
APPSwe/PSEN1ΔE9小鼠中M1胆碱能受体调节引起阿尔茨海默病病理生理学的性别差异改变
Wesam Bassiouni,Emily Ye,Tash-Lynn L Colson et al.
Wesam Bassiouni et al.
Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline, where females account for 60% of diagnosed cases. AD is featured by β-amyloid deposition, which influences the activity of M1 muscarinic acetylcholine re...
Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model [0.03%]
阻断白介素-33可减少联合型胶原诱导性关节炎-吸入内毒素暴露模型的关节、全身和肺部炎症反应
Jill A Poole,Jacob L Larsen,Geoffrey M Thiele et al.
Jill A Poole et al.
Therapies capable of resolving rheumatoid arthritis (RA)-associated lung disease, particularly in the setting of environmental exposures, are lacking. This study sought to determine whether blocking interleukin (IL)-33 in a murine model of ...
Keeping it acid ceramidase: How adiponectin protects in the glomerulus [0.03%]
保持酸性鞘氨醇胺酶活性：脂联素如何在肾小球中发挥保护作用
Noelle I Frambes,Erin B Taylor,Jennifer C Sullivan et al.
Noelle I Frambes et al.
Preclinical pharmacology of N-pyrrolidino "nitazene" opioids appearing in nonmedical drug markets [0.03%]
在非医药市场出现的N-吡咯烷基“尼塔津类”阿片类药物的临床前药理学研究
Grant C Glatfelter,Alexander D Maitland,Nicholas R Gonzalez et al.
Grant C Glatfelter et al.
N-pyrrolidino (PYR) nitazenes are a subset of 2-benzylbenzimidazole opioids appearing in illicit drug markets, but there is limited information about the pharmacology of these compounds. Here, we examined the opioid-like effects of PYR nita...
α-Synuclein regulates monoamine transporter capacity and amphetamine-induced efflux via modulation of transporter expression [0.03%]
α-突触核蛋白通过调节转运体的表达来调控单胺转运体容量及安非他明诱导的释放作用
Iina Ludwig,Samuel Moser,Marina Lukenic et al.
Iina Ludwig et al.
α-Synuclein (α-syn) is a presynaptic protein implicated in Parkinson disease and related synucleinopathies, but its physiological function remains incompletely understood. Monoamine transporters, including the dopamine transporter (DAT) a...
Bronchorelaxant and anti-inflammatory profile of ensifentrine alone and combined with inhaled medications in lipopolysaccharide-challenged human airways from chronic obstructive pulmonary disease donors [0.03%]
源自慢性阻塞性肺病供者的气道内LPS刺激后，恩昔芬特单药和联合吸入药物的支气管舒张作用及抗炎特性
Luigino Calzetta,Tara Rheault,Shima Gholamalishahi et al.
Luigino Calzetta et al.
The ENHANCE trials demonstrated that ensifentrine (CAS Number 1884461-72-6), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor, offers additional benefits in chronic obstructive pulmonary disease (COPD). Its bifunctional activity warran...
PRT-064040: A nasal spray of novel, potent, and selective calcitonin gene-related peptide receptor antagonist for migraine [0.03%]
新型高效选择性降钙素基因相关肽受体拮抗剂鼻喷雾PRT-064040治疗偏头痛
Shuwen Du,Hao Yang,Jingmei Yue et al.
Shuwen Du et al.
Calcitonin gene-related peptide (CGRP), a neuropeptide, has been implicated in autoimmune diseases, endometriosis, tumors, and primary headaches, including migraine. The development of a novel, fast-acting CGRP receptor antagonist administe...
Xylazine's κ relatively potent opioid agonist activity is not shared with other US Food and Drug Administration-approved α2-adrenergic agonists [0.03%]
氯胺酮的κ阿片受体激动活性不是美国食品药品监督管理局批准的其他α2-肾上腺素受体激动剂共有的性质
Xi-Ping Huang,Brian E Krumm,Madigan L Bedard et al.
Xi-Ping Huang et al.
Xylazine is an α2-adrenergic agonist typically used in as a sedative and analgesic in veterinary medicine. For some years, xylazine has been reported as an additive to fentanyl on the illicit drug market and has been associated with severe...
Silencing thyroid hormone receptor interactor 13/kinetochore-associated 1 inhibits DNA damage repair and enhances Olaparib sensitivity in ovarian cancer [0.03%]
沉默甲状腺激素受体相互作用蛋白13/动粒相关蛋白1抑制DNA损伤修复并增强卵巢癌细胞对奥拉帕尼的敏感性
Xingzi Guo,Jie Tang,He Li et al.
Xingzi Guo et al.
Ovarian cancer (OC) is associated with high mortality and frequent resistance to poly (ADP-ribose) polymerase inhibitors, such as Olaparib, particularly in patients with breast cancer gene-proficient tumors. To explore the potential mechani...
Heat shock factor 1 signaling: A novel pathway implicated in Rett syndrome pathophysiology [0.03%]
热休克因子1信号通路：雷特综合征病理生理学中的一种新途径
Sonia Gonzalez,Amanda M Vanderplow,Theresa R Wilsterman et al.
Sonia Gonzalez et al.
Rett syndrome (RTT) is a neurodevelopmental disorder that is associated with loss-of-function mutations in the methyl CpG binding protein 2 (MECP2) gene. MECP2 regulates transcription both locally and globally, making it challenging to dist...