Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism [0.03%]
番石榴素诱导的CYP1酶抑制及对雌二醇代谢的影响
Xu Mao,Jian Wang,Qian Wang et al.
Xu Mao et al.
The cytochrome P450 (P450) 1 family is an important phase I enzyme involved in carcinogen activation. Nitidine chloride (NC) is a pharmacologically active alkaloid with polyaromatic hydrocarbon found in the roots of Zanthoxylum nitidum (Rox...
Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice [0.03%]
利用人类化CYP1A1/1A2和Cyp1a1/Cyp1a2敲除小鼠定义CYP1A1和CYP1A2在药物代谢中的作用
Y Kapelyukh,C J Henderson,N Scheer et al.
Y Kapelyukh et al.
Cytochrome P450s CYP1A1 and CYP1A2 can metabolize a broad range of foreign compounds and drugs. However, these enzymes have significantly overlapping substrate specificities. To establish their relative contribution to drug metabolism in vi...
Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice [0.03%]
多溴二苯醚和肠道微生物群调节小鼠与代谢综合征相关的水相代谢物
David K Scoville,Cindy Yanfei Li,Dongfang Wang et al.
David K Scoville et al.
Polybrominated diphenyl ethers (PBDEs) are persistent environmental toxicants associated with increased risk for metabolic syndrome. Intermediary metabolism is influenced by the intestinal microbiome. To test the hypothesis that PBDEs reduc...
Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics [0.03%]
定量蛋白质组学测定肾皮质转运蛋白的物种差异
Abdul Basit,Zaher Radi,Vishal S Vaidya et al.
Abdul Basit et al.
Limited understanding of species differences in kidney transporters is a critical knowledge gap for prediction of drug-induced acute kidney injury, drug interaction, and pharmacokinetics in humans. Here, we report protein abundance data of ...
Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1 [0.03%]
有机阴离子转运多肽2B1基因敲除小鼠体内的氟芬那酸和罗苏伐他汀的药动学研究
Samantha Medwid,Mandy M J Li,Michael J Knauer et al.
Samantha Medwid et al.
Organic anion transporting polypeptide 2B1 (OATP2B1) is a widely expressed membrane transporter with diverse substrate specificity. In vitro and clinical studies suggest a role for intestinal OATP2B1 in the oral absorption of medications. M...
Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo [0.03%]
活化孕烷X受体-细胞色素P450轴：聚乙二醇化脂质体体内加速血液清除现象增强的可能原因
Fengling Wang,Huihui Wang,Yifan Wu et al.
Fengling Wang et al.
Recently, we reported that repeated injection of PEGylated liposomes (PEG-L) at certain intervals to the same rat lead to the disappearance of their long-circulation properties, referred to as the "accelerated blood clearance (ABC) phenomen...
Philip Gardiner,Rhona J Cox,Ken Grime
Philip Gardiner
The low volume of distribution associated with acidic molecules means that clearance (CL) must also be very low to achieve an effective half-life commensurate with once or twice daily dosing. Plasma protein binding (PPB) should not usually ...
Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism [0.03%]
肝硫酸转移酶的发育生物学及其在对乙酰氨基酚代谢中的作用预测
Mayur K Ladumor,Deepak Kumar Bhatt,Andrea Gaedigk et al.
Mayur K Ladumor et al.
Cytosolic sulfotransferases (SULTs), including SULT1A, SULT1B, SULT1E, and SULT2A isoforms, play noteworthy roles in xenobiotic and endobiotic metabolism. We quantified the protein abundances of SULT1A1, SULT1A3, SULT1B1, and SULT2A1 in hum...
Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA [0.03%]
N-乙酰半乳糖胺修饰的小干扰RNA的血浆和肝脏蛋白结合研究
Sara C Humphreys,Mai B Thayer,Julie M Lade et al.
Sara C Humphreys et al.
Understanding small interfering RNA (siRNA) fraction unbound (f u) in relevant physiologic compartments is critical for establishing pharmacokinetic-pharmacodynamic relationships for this emerging modality. In our attempts to isolate the eq...