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Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism

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The cytochrome P450 (P450) 1 family is an important phase I enzyme involved in carcinogen activation. Nitidine chloride (NC) is a pharmacologically active alkaloid with polyaromatic hydrocarbon found in the roots of Zanthoxylum nitidum (Roxb.) DC, a traditiona... ...