Platelet activation, aspirin, and cancer: From basic science to clinical trials [0.03%]
血小板活化、阿司匹林和癌症：从基础研究到临床试验
Carlo Patrono,John Burn,Paola Patrignani et al.
Carlo Patrono et al.
There is extensive evidence that aspirin prevents cancer, but the mechanism of action is uncertain. Once-daily low-dose aspirin (75-100 mg) completely and permanently inactivates the cyclooxygenase (COX) activity of prostaglandin G/H syntha...
The neuropharmacological basis of placebo analgesia: Mechanisms and clinical applications in the context of chronic pain [0.03%]
安慰剂镇痛的神经药理学基础：慢性疼痛背景下机制及临床应用
Damien C Boorman,Lewis S Crawford,Zahra Siddiqi et al.
Damien C Boorman et al.
The therapeutic value of placebo analgesia to treat conditions of chronic pain is both underappreciated and understudied. It is now abundantly clear that chronic pain is caused by a complex array of biological adaptations, including changes...
Animal models of attention-deficit/hyperactivity disorder: Diversity and validity [0.03%]
注意缺陷多动障碍的动物模型：多样性与有效性
Bou Sader Nehme Sarah,Sánchez-Sarasúa Sandra,Medrano Mari-Carmen et al.
Bou Sader Nehme Sarah et al.
Attention-deficit/hyperactivity disorder (ADHD) is one of the most widespread neurodevelopmental disorders globally, marked by chronic symptoms of inattention and/or hyperactivity-impulsivity. Its multifactorial origin and phenotypic hetero...
Targeting fatty acid synthase for cancer drug discovery: Retrospective analyses and outlook [0.03%]
脂肪酸合酶在癌症药物发现中的作用：回顾与展望
Qingbin Cui,Sophia Josephraj,Boqing Gu et al.
Qingbin Cui et al.
Enhanced de novo lipogenesis is a hallmark of cancer cells, enabling their proliferation, metastasis, and resistance to therapy. Among key lipogenic enzymes, fatty acid synthase (FASN) is frequently overexpressed in cancer but minimally exp...
Leading artificial intelligence-driven drug discovery platforms: 2025 landscape and global outlook [0.03%]
人工智能驱动的药物发现平台：2025年的发展格局与全球展望
Mahendiran Dharmasivam,Busra Kaya,Adedoyin Akinware et al.
Mahendiran Dharmasivam et al.
Artificial intelligence (AI) has progressed from experimental curiosity to clinical utility, with AI-designed therapeutics now in human trials across diverse therapeutic areas. This review critically compares 5 leading AI-driven discovery p...
Synergistic combinations of antimicrobial peptides and conventional antibiotics: A strategy to delay resistance emergence in World Health Organization priority bacteria [0.03%]
联合使用抗菌肽和传统抗生素：延缓世界卫生组织重点细菌耐药性产生的一种策略
Cesar Augusto Roque-Borda,Qi Zhang,Thi Phuong Truc Nguyen et al.
Cesar Augusto Roque-Borda et al.
Antimicrobial resistance represents one of the most pressing global health challenges of the 21st century, significantly compromising the efficacy of conventional antibiotics. In response to this crisis, the World Health Organization has up...
Jürgen Drewe,Marc Foretz,Stephan Krähenbühl
Jürgen Drewe
Metformin currently serves as the basis of oral treatment for patients with type 2 diabetes. While metformin's effect on glycemia is well established, its mode of action remains unclear. In clinical studies, long-term metformin treatment im...
Computational drug design in the artificial intelligence era: A systematic review of molecular representations, generative architectures, and performance assessment [0.03%]
人工智能时代的计算药物设计系统评价：分子表示、生成架构及性能评估方法综述
Karim Abbasi,Parvin Razzaghi,Ali Gharizadeh et al.
Karim Abbasi et al.
Generative drug design has emerged as a transformative approach in pharmaceutical research, leveraging deep learning models to create novel molecules with targeted properties. This systematic review analyzes the current landscape of computa...
Ahad A Rahim,Manju A Kurian,Haiyan Zhou et al.
Ahad A Rahim et al.
Often, gene therapy reviews concentrate upon specific therapeutic modalities-particularly either viral vector-mediated or a nonviral approach. Here, we draw together a comprehensive array of knowledge across the field of genetic therapy for...
Artificial intelligence-assisted drug discovery in 2025: Faster, but is it better? The robots are coming, look out! [0.03%]
人工智能助力的药物发现会在2025年大行其道吗？机器人要来了，小心！
Mahendiran Dharmasivam,Mahan Gholam Azad,Vera Richardson et al.
Mahendiran Dharmasivam et al.