Peptide hormone-based combinational pharmacotherapies for chronic metabolic diseases [0.03%]
基于肽激素的慢性代谢疾病的联合药物治疗
Zara Siu Wa Chui,Yaqian Xue,Xiaoping Wu et al.
Zara Siu Wa Chui et al.
Peptide hormones play a central role in maintaining metabolic homeostasis by integrating complex signaling pathways to coordinate interorgan crosstalk. Aberrant production and/or dysfunction of peptide hormones are important contributors to...
Chronic pain in Alzheimer disease and the role of neuroimmune interactions [0.03%]
阿尔茨海默病的慢性疼痛及神经免疫相互作用的作用机制
Marzia Malcangio,George Sideris-Lampretsas
Marzia Malcangio
Chronic pain conditions affect a large proportion of the global population and pain has tremendous personal and economic impact, affecting quality of life and ability to work while imposing a significant burden on families and health care s...
Renal aging and associated diseases: Common mechanisms and therapeutic approaches [0.03%]
肾脏衰老及相关的疾病：共同的机制和治疗方法
Jabir Aliyu Muhammad,Nadya Marcelina Julianto,Tania Setiawan et al.
Jabir Aliyu Muhammad et al.
The kidneys are highly metabolically active organs that undergo a progressive, intrinsic decline in renal function with aging, a process that can be further exacerbated by chronic exposure to oxidative stress, inflammation, hypertension, an...
Recent advances in methotrexate pharmacology and potential therapeutic uses in age-related cardiometabolic and neurodegenerative diseases [0.03%]
甲氨蝶呤药理学的新进展及其在年龄相关的心代谢和神经退行性疾病治疗中的潜在应用
Arduino A Mangoni,Julie-Ann Hulin,Sara Tommasi
Arduino A Mangoni
Experimental and clinical evidence continues to accumulate, supporting the critical role of dysregulated inflammation, immunity, and redox signaling in the pathophysiology of various age-related cardiometabolic and neurodegenerative disease...
Exploration of multifunctional characteristics and regulatory mechanism of promoter G-quadruplexes [0.03%]
启动子G-四链体的功能特征及调控机制探究
Ziyi Zhao,Yangzi Zhang,Jingjing Tian et al.
Ziyi Zhao et al.
G-quadruplexes (G4s), a specialized nucleic acid secondary structure, have been found in recent years to be widely distributed in gene promoter regions. Growing evidence has highlighted the significance of G4 structures of promoter region i...
Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential [0.03%]
芳烃受体药理学-机制、配体和治疗潜力
Raitis Bobrovs,Ninni Elise Olafsen,Samaneh Shabani Åhrling et al.
Raitis Bobrovs et al.
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that has emerged as a key modulator of several physiological and pathological processes. Historically, AHR has been studied for its role as a mediator of the tox...
Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches [0.03%]
mast细胞蛋白酶及其在生理、病理和治疗中的意义
Afshin Derakhshani,Leela Mahajan,Kyle Lesack et al.
Afshin Derakhshani et al.
Mast cells (MCs) are versatile, multifunctional immune cells with broad roles in physiological homeostasis and pathogenic processes. MCs are found in most tissues, including skin, lungs, intestines, and peritoneum, and they vary in numbers,...
Translational medications development for methamphetamine use disorder: A systematic review of preclinical, human laboratory, and clinical research [0.03%]
甲基苯丙胺使用障碍的转化药物开发：对临床前、人体实验室和临床研究的系统性综述
Alexandra N Johansen,Mark A Smith,William W Stoops
Alexandra N Johansen
The prevalence of methamphetamine use disorder (MUD) remains discouragingly high. Relatively few clinical trials have focused on identifying new pharmacotherapies for MUD, and no medications have received US Food and Drug Administration app...
Reharnessing the therapeutic potential of gallium-based compounds in oncology: From the laboratory to the clinic [0.03%]
基于加拉爽化合物的抗肿瘤药物的临床应用及机制研究从实验室到临床
Christopher R Chitambar,Casey J Zoss,Mona M Al-Gizawiy et al.
Christopher R Chitambar et al.
Despite advances in the treatment of certain malignancies, it is anticipated that there will be 626,140 cancer deaths in the United States in 2026. Thus, there remains a great need to develop new antineoplastic drugs with unique mechanisms ...
Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions [0.03%]
抗菌和抗病毒疗法的药物基因组学：临床应用性、证据缺口及未来方向
Maria K Smatti,Zainab Jan,Hadi M Yassine
Maria K Smatti
Anti-infective drugs have profoundly transformed the history of medicine. Yet, with the presence of approximately 4.1-5 million interindividual genomic variants in human genome, patients are expected not to respond equally to the same anti-...