Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy [0.03%]
基于金属的抗体、纳米抗体和肽结合物：治疗乳腺癌的潜力
Busra Kaya,Devina Laurencia,Maseeha Farha Ayoub et al.
Busra Kaya et al.
Globally, breast cancer (BC) remains the leading cause of cancer death in women. BC profoundly impacts the physical and psychological well being of millions of families worldwide and significantly burdens the healthcare system and the econo...
The evolution of lipid-lowering drugs in the management of cardiovascular disease risk: From the first cardiovascular disease risk-reducing therapies to the novel challenging strategies [0.03%]
血脂调节药物在心血管疾病风险防控中的演变：从第一个能够降低心血管风险的疗法到新的具有挑战性的策略
Doriane Henry,Eric Baugé,Bart Staels et al.
Doriane Henry et al.
Before the Framingham Heart Study, the concept of cardiovascular disease (CVD) risk factors did not exist, and CVDs were seen as a consequence of aging. The first 2 reports in 1957 and 1961 identified high cholesterol levels as a major risk...
Nancy Padilla-Coreano,Freddyson J Martínez-Rivera
Nancy Padilla-Coreano
Many species, including humans, rely on social interactions to thrive and survive. These life interactions engage many neural systems, including those used for learning, cognition, and innate behaviors that are fundamentally guided by rewar...
Modern antidiabetic therapy by sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, and dipeptidyl peptidase 4 inhibitors against cardiovascular diseases [0.03%]
现代用于防治心血管疾病的钠-葡萄糖共转运蛋白2抑制剂、胰高血糖素样肽-1受体激动剂和二肽基肽酶4抑制剂的抗糖尿病疗法
Sebastian Steven,Marin Kuntic,Thomas Münzel et al.
Sebastian Steven et al.
Diabetes and related metabolic diseases have a high prevalence with increasing incidence and create a significant socioeconomic burden by their contribution to global mortality and disability-adjusted life years. According to data from the ...
Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions [0.03%]
创伤性癫痫治疗的实验模型研究进展与挑战
Doodipala Samba Reddy,Victoria M Golub,Sreevidya Ramakrishnan et al.
Doodipala Samba Reddy et al.
Epilepsy affects over 80 million people worldwide, with approximately 40% experiencing refractory seizures. Despite some progress in deciphering the complex process of epileptogenesis, which transforms a healthy brain into one susceptible t...
Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system [0.03%]
肽类作为蓝斑noradrenergic系统的递质和调节因素
Léa J Becker,Madison M Martin,Alex C Hughes et al.
Léa J Becker et al.
The locus coeruleus (LC), the brain's main source of noradrenaline, has received increased attention due to the recently unveiled heterogeneity of its cell types. Departing from the long-standing idea of molecular, anatomical, and functiona...
Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy [0.03%]
开发缺氧诱导因子的小分子抑制剂用于癌症治疗
Gregg L Semenza
Gregg L Semenza
The hypoxia-inducible factors (HIFs)-HIF-1 and HIF-2-play critical roles in cancer progression by controlling the transcription of thousands of genes across the full range of human cell types. Inhibition of their activity blocks cancer grow...
Role of exchange proteins directly activated by cAMP signaling in vascular remodeling [0.03%]
交换蛋白活化的小信号通路在血管重塑中的作用
Xiaodong Cheng,Hua Liu,Wenbo Zhang et al.
Xiaodong Cheng et al.
Vascular remodeling is a complex process involving the coordinated actions of multiple cellular signaling pathways in various cell types, leading to structural and functional changes in blood vessels. These changes can be adaptive, as in wo...
The complement system: Biology, pathology, and therapeutic interventions [0.03%]
补体系统：生物学、病理学和治疗干预措施
Xaria X Li,Trent M Woodruff
Xaria X Li
Targeting the innate immune complement system has long been pursued as a promising strategy for treating a wide spectrum of acute and chronic immune-mediated disorders. Nearly 2 decades since the approval of the first complement inhibitor t...
Cell and tissue reprogramming: Unlocking a new era in medical drug discovery [0.03%]
细胞和组织重编程：解锁医学药物发现的新时代
Chandan K Sen,Andrew J Friday,Sashwati Roy
Chandan K Sen
Recent advancements in cell and tissue biology have fundamentally changed our understanding of cellular behavior, revealing that both stem and nonstem cells exhibit remarkable plasticity and adaptability. This discovery has paved the way fo...