Stereoselective Synthesis of 2,6-trans-Tetrahydropyrans via Tandem Horner-Wadsworth-Emmons Olefination of Lactols/Intramolecular Oxa-Conjugate Cyclization [0.03%]
通过Horner-Wadsworth-Emmons串联 olefination/lactol 酰基化及分子内氧杂-[3,3] sigmatropic重排合成2,6-反式四氢吡喃类化合物
Katsiaryna A Nekrasava,Vitaly Syakhovich,Uladzimir S Masiuk
Katsiaryna A Nekrasava
Tandem approaches based on intramolecular oxa-conjugate cyclization of ζ-hydroxy-α,β-unsaturated carbonyl compounds provide an efficient route to 2,6-disubstituted tetrahydropyrans (THPs). However, existing methods are limited to the syn...
B(C6F5)3-Catalyzed [4 + 2] Cycloaddition Reaction: Synthesis of Polycyclic N-Heterocycle Fused Naphthoquinones [0.03%]
B(C6F5)3催化的[4 + 2]环加成反应：多环氮杂芳环稠合萘醌的合成
Yu Dong,Xiangyu Xiao,Junhui Liu et al.
Yu Dong et al.
In this paper, a novel strategy to a series of polycyclic N-heterocycle-fused naphthoquinones by a B(C6F5)3-catalyzed [4 + 2] cycloaddition reaction is reported. This approach is featured with a wide substrate scope, moderate to excellent y...
Mechanochemical Diastereoselective Substrate-Directed Synthesis of Pyrrole-Isoxazolidines via 1,3-Dipolar Cycloaddition of Maleimides with Nitrones [0.03%]
通过马来酰亚胺与硝酮的1,3-偶极环加成合成手性吡咯异噁唑啶类化合物的机械化学差向选择性底物导向合成方法
Iva S de Jesus,Anna Flávia da C Lédo,Armando Ferrer et al.
Iva S de Jesus et al.
An efficient and sustainable substrate-directed mechanochemical synthesis of pyrrole-isoxazolidines was developed via the 1,3-dipolar cycloaddition of maleimides with nitrones. Moderate to good yields were generally obtained, and the diaste...
Enediyne Chimeras for Targeted NAMPT Degradation: Enhancing Cytotoxicity via a Radical Clock [0.03%]
用于靶向降解NAMPT的烯二炔杂合物：通过自由基钟增强细胞毒性
Xiang Li,Song Wang,Wei Zhang et al.
Xiang Li et al.
Based on a novel targeted protein degradation platform, Protein-Radical-Oxidation Targeting Enediyne Chimera (PROTEC), a series of chimeric enediyne compounds targeting the oncogenic protein nicotinamide phosphoribosyltransferase (NAMPT) we...
Photoinduced Synthesis of α-Aryl-β-arylthiopropanamide from N-(Arylsulfonyl)methacrylamide via Smiles Rearrangement [0.03%]
通过Smiles重排由N-（芳基磺酰基）甲基丙烯酰胺光诱导合成α-芳基-β-芳基亚硫酰胺化合物
Litao Liu,Bo Wang,Mingcai Teng et al.
Litao Liu et al.
We report a photoinduced, sulfur-radical-mediated Smiles rearrangement for the mild and operationally simple synthesis of α-aryl-β-arylthiopropanamide derivatives. This method requires no external photocatalysts or oxidants and offers a s...
Cu-Catalyzed Regio- and Diastereoselective Propargylic Substitution of N-Hydroxyphthalimide Esters: Access to Propargyl-Containing N,O-Acetal Derivatives [0.03%]
铜催化N-羟基苯并酰胺酯的炔丙基取代反应：用于合成含炔丙基的缩醛衍生物的方法
Xinkun Wang,Peisen Yu,Yu Zhou et al.
Xinkun Wang et al.
Herein, we report the copper-catalyzed propargylic substitution reaction between N-acyl phenylglycine N-hydroxyphthalimide (NHP) esters as a direct C-2-position nucleophile to racemic propargylic carbonates. The reaction affords multifuncti...
Stereoselective Substituted Oxasilinane Synthesis from Diallylsilanes via Electrophile-Promoted Rearrangement, RCM, and Re-Catalyzed Allylic Transposition [0.03%]
通过亲电子促进的重排、RCM和再催化烯丙基转位由茋硅烷立体选择性合成取代氧化硅烷
Gregory W O&#x;Neil,Inna A Fomina,Christopher R Myers et al.
Gregory W O&#x;Neil et al.
A new synthesis of substituted oxasilinanes is described, starting from diallylsilanes and featuring a diastereoselective rhenium(VII) oxide-catalyzed allylic transposition of an intermediate 8-membered ring cyclic silyl ether. The results ...
Photocatalyzed Radical Migration and C-H Oxidation Enabling Access to Terminal Trifluoromethylated Ketones [0.03%]
光催化自由基迁移及脱氢氧化合成末端三氟甲基酮化合物
Yuhong Ma,Man Chen,Huanyi Guo et al.
Yuhong Ma et al.
A visible-light-driven photocatalyzed C-H functionalization strategy for the synthesis of terminal trifluoromethylated ketones has been developed via 1,5- and 1,6-hydrogen atom transfer (1,5-HAT) under mild conditions with Ir(ppy)3 as the p...
Bottom-Up Synthesis of Pyrene-Based Polycyclic Aromatic Hydrocarbons with Tunable Emission Properties [0.03%]
基于菲的发射性质可调的大共轭多环芳香烃的合成
Zhenkai Na,Xiaoxuan Lin,Jialin Li et al.
Zhenkai Na et al.
This study demonstrates a rational molecular design strategy for the construction of well-defined polycyclic aromatic hydrocarbons (PAHs) fragments through regioselective functionalization at the active 1,3-positions and the sterically hind...
Synthesis of Iodomethyl Benzosultams via an Electrochemical Intramolecular Iodoamination/Cyclization of Olefinic Benzenesulfonamides [0.03%]
通过电化学分子内碘𬭩化/环化烯烃苯磺酰胺的芳基甲基苯并砜合成
Yingliang Yu,Dongping Xu,Lizhen Jin et al.
Yingliang Yu et al.
An efficient electrochemical iodoamination of olefinic benzenesulfonamides has been developed for the synthesis of iodomethyl-substituted five-membered benzosultams. This straightforward oxidative iodoaminocyclization proceeds under constan...