Fahmeed Sheehan,Deborah Sementa,Ankit Jain et al.
Fahmeed Sheehan et al.
Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to use conserved sets of building blocks and chemical reactions to achieve a bewildering array of functions. Building on the design principles for short...
Hannah M Britt,Tristan Cragnolini,Konstantinos Thalassinos
Hannah M Britt
Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of proteins and the complexes they form with other macromolecules. There are now several specialized MS methods, each with unique sample preparation, data...
Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems [0.03%]
氢氘交换质谱研究的最新进展及其在生物大分子动态修饰中的应用
Ellie I James,Taylor A Murphree,Clint Vorauer et al.
Ellie I James et al.
Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is a widespread tool for structural analysis across academia and the biopharmaceutical industry. By monitoring the exchangeability of backbone amide protons,...
Chunghwan Jung,Gyeongtae Kim,Minsu Jeong et al.
Chunghwan Jung et al.
Optically variable devices (OVDs) are in tremendous demand as optical indicators against the increasing threat of counterfeiting. Conventional OVDs are exposed to the danger of fraudulent replication with advances in printing technology and...
Márkó Grabarics,Maike Lettow,Carla Kirschbaum et al.
Márkó Grabarics et al.
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins, and glycans. Although glycans are essential to all living organisms, surprisingly little is known about the "sugar code" and the biological roles of t...
Mixed Ionic and Electronic Conduction in Small-Molecule Semiconductors [0.03%]
小分子半导体中的离子和电子混合导体性质研究
Christina J Kousseff,Roman Halaksa,Zachary S Parr et al.
Christina J Kousseff et al.
Small-molecule organic semiconductors have displayed remarkable electronic properties with a multitude of π-conjugated structures developed and fine-tuned over recent years to afford highly efficient hole- and electron-transporting materia...
Mechanics of 3D Cell-Hydrogel Interactions: Experiments, Models, and Mechanisms [0.03%]
三维细胞-水凝胶相互作用的力学：实验、模型和机制
Franck J Vernerey,Shankar Lalitha Sridhar,Archish Muralidharan et al.
Franck J Vernerey et al.
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising cell-delivery vehicles for applications in tissue engineer...
Amber D Rolland,James S Prell
Amber D Rolland
Native mass spectrometry (MS) is aimed at preserving and determining the native structure, composition, and stoichiometry of biomolecules and their complexes from solution after they are transferred into the gas phase. Major improvements in...
Matthew M D Roy,Alvaro A Omaña,Andrew S S Wilson et al.
Matthew M D Roy et al.
This review serves to document advances in the synthesis, versatile bonding, and reactivity of molecular main group metal hydrides within Groups 1, 2, and 12-16. Particular attention will be given to the emerging use of said hydrides in the...
Jack L Bennett,Giang T H Nguyen,William A Donald
Jack L Bennett
Small molecule drug discovery has been propelled by the continual development of novel scientific methodologies to occasion therapeutic advances. Although established biophysical methods can be used to obtain information regarding the molec...