Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy [0.03%]
癌症免疫治疗中用于激活STING信号通路的化学和生物分子策略
Kyle M Garland,Taylor L Sheehy,John T Wilson
Kyle M Garland
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the production of a multifaceted array of immunostimulatory molecul...
Yoonho Kim,Xuanhe Zhao
Yoonho Kim
In conventional classification, soft robots feature mechanical compliance as the main distinguishing factor from traditional robots made of rigid materials. Recent advances in functional soft materials have facilitated the emergence of a ne...
Axel Groß,Sung Sakong
Axel Groß
Structures and processes at water/metal interfaces play an important technological role in electrochemical energy conversion and storage, photoconversion, sensors, and corrosion, just to name a few. However, they are also of fundamental sig...
Fabrizio Ortu
Fabrizio Ortu
The number of rare earth (RE) starting materials used in synthesis is staggering, ranging from simple binary metal-halide salts to borohydrides and "designer reagents" such as alkyl and organoaluminate complexes. This review collates the mo...
Dynamic Nuclear Polarization for Sensitivity Enhancement in Biomolecular Solid-State NMR [0.03%]
动态核偏置在生物分子固态NMR敏感度增强中的应用
Thomas Biedenbänder,Victoria Aladin,Siavash Saeidpour et al.
Thomas Biedenbänder et al.
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural biology. While NMR can provide invaluable information about local geometry on an atomic scale even for large biomolecular assemblies lacking long-range ord...
Ivan B Dimov,Maximilian Moser,George G Malliaras et al.
Ivan B Dimov et al.
Electronically interfacing with the nervous system for the purposes of health diagnostics and therapy, sports performance monitoring, or device control has been a subject of intense academic and industrial research for decades. This trend h...
Qing Miao,Christoph Nitsche,Henry Orton et al.
Qing Miao et al.
Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent years witnessed a great increase in the variety of probes for the stud...
Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering [0.03%]
微流控技术在脑科学研究中的新兴角色：从脑脊液操控到类脑芯片及神经电子器件工程
Jiandi Wan,Sitong Zhou,Hing Jii Mea et al.
Jiandi Wan et al.
Remarkable progress made in the past few decades in brain research enables the manipulation of neuronal activity in single neurons and neural circuits and thus allows the decipherment of relations between nervous systems and behavior. The d...
Paolo Melchiorre
Paolo Melchiorre
Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection [0.03%]
大面积单分子无标记生物电子传感界面
Eleonora Macchia,Fabrizio Torricelli,Paolo Bollella et al.
Eleonora Macchia et al.
Bioelectronic transducing surfaces that are nanometric in size have been the main route to detect single molecules. Though enabling the study of rarer events, such methodologies are not suited to assay at concentrations below the nanomolar ...