A Alec Talin,Bilge Yildiz
A Alec Talin
Qi Sun,Hanping Wang,Juan Xie et al.
Qi Sun et al.
Undruggable targets are those of therapeutical significance but challenging for conventional drug design approaches. Such targets often exhibit unique features, including highly dynamic structures, a lack of well-defined ligand-binding pock...
Gibae Kim,R Justin Grams,Ku-Lung Hsu
Gibae Kim
Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Covalent chemistry has emerged...
Ghazi Sarwat Syed,Manuel Le Gallo,Abu Sebastian
Ghazi Sarwat Syed
In-memory computing (IMC) is an emerging computational approach that addresses the processor-memory divide in modern computing systems. The core concept is to leverage the physics of memory devices and their array-level organization to perf...
Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores [0.03%]
单细胞纳米包封：人工“细胞孢子”的化学合成
Hyeong Bin Rheem,Nayoung Kim,Duc Tai Nguyen et al.
Hyeong Bin Rheem et al.
Nature has evolved adaptive strategies to protect living cells and enhance their resilience against hostile environments, exemplified by bacterial and fungal spores. Inspired by cryptobiosis in nature, chemists have designed and synthesized...
Perovskite Solar Cells and Light Emitting Diodes: Materials Chemistry, Device Physics and Relationship [0.03%]
钙钛矿太阳能电池和发光二极管：材料化学、器件物理及其关系
Ligang Yuan,Qifan Xue,Feng Wang et al.
Ligang Yuan et al.
Solution-processed perovskite solar cells (PSCs) and perovskite light emitting diodes (PeLEDs) represent promising next-generation optoelectronic technologies. This Review summarizes recent advancements in the application of metal halide pe...
Residue-Specific Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts: Quo Vadis? [0.03%]
无规范氨基酸在突变宿主中的残基特异性引入：何处去？
Žana Marin,Claudia Lacombe,Simindokht Rostami et al.
Žana Marin et al.
The residue-specific incorporation of noncanonical amino acids in auxotrophic hosts allows the global exchange of a canonical amino acid with its noncanonical analog. Noncanonical amino acids are not encoded by the standard genetic code, bu...
Marcus H Sak,Eric N Jacobsen
Marcus H Sak
In catalysis, selectivity reflects the energetic preference for the formation of a single product out of multiple possible reaction outcomes. The classic steric biasing approach in small-molecule catalysis employs steric destabilization of ...
Donglin Jiang,Vincent Guan Wu Tan,Yifan Gong et al.
Donglin Jiang et al.
Semiconductors form the foundational bedrock of modern electronics and numerous cutting-edge technologies. Particularly, semiconductors crafted from organic building blocks hold immense promise as next-generation pioneers, thanks to their v...
Photolithographic Patterning of Organic Semiconductors for Organic Field-Effect Transistors [0.03%]
有机半导体的光刻图案化用于有机薄膜晶体管(Organic field-effect transistors)
Yang Li,Renzhong Chen
Yang Li
Over the past 25 years, three major photolithography strategies have been employed for patterning organic semiconductors in organic field-effect transistors (OFETs): modified photolithography (MPL), orthogonal photolithography (OPL), and di...