Monitoring Membrane Protein Folding Assisted by Insertases and Translocases Using AFM-Based Single-Molecule Force Spectroscopy [0.03%]
基于原子力显微镜的单分子力谱技术监测插入酶和转运酶辅助的膜蛋白折叠
Tetiana Serdiuk,Johannes Thoma,Daniel J Müller
Tetiana Serdiuk
In this review we discuss how atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) approaches can be applied to monitor the unfolding and folding pathways of individual membrane proteins. Particularly, we focus on t...
From Fundamental Chemistry to Biological Function: The Biological and Abiological Chemistry of Metal Persulfides and Related Species [0.03%]
从基础化学到生物功能：金属过硫化物及相关的物种的生物和非生物化学
Keyan Li,Michael D Pluth
Keyan Li
Biological sulfur species have emerged as versatile mediators of redox chemistry, linking thiol-based signaling, oxidative stress response, and metabolic regulation. Among these species, persulfides (RSSH) occupy a unique chemical niche def...
Yunxuan Li,Tim Karrasch,Ulrich F Keyser et al.
Yunxuan Li et al.
Transmembrane-spanning nanopores have emerged as powerful tools in a wide range of technological applications, particularly in single-molecule sensing. This review explores recent advancements in creating synthetic, membrane-spanning nanopo...
Metal-Catalyzed Reductive Coupling of Aryl Halides beyond Premetalated Reagents or Metallic Reductants: Biaryl Formation [0.03%]
无金属催化剂的芳基卤化物还原偶联及茋类化合物的形成
Yoon Cho,Yu-Hsiang Chang,Weijia Shen et al.
Yoon Cho et al.
Biaryl motifs figure prominently in commercial pharmaceutical and agrochemical ingredients and are used widely in organic optoelectronic materials. Traditional palladium-catalyzed cross-coupling reactions, such as Suzuki, Negishi and Stille...
Membrane Protein Folding and Biogenesis: Insights from Single-Molecule Force Spectroscopy [0.03%]
单分子力谱学揭示的膜蛋白折叠与生物发生机制
Sang Ah Kim,Seoyoon Kim,Jaehyun Nam et al.
Sang Ah Kim et al.
Membrane proteins perform essential cellular functions, and their remarkable versatility arises from the precise assembly of complex folded structures within the dynamic lipid bilayer environment. Deciphering their folding mechanisms and pa...
Structure, Interactions, and Assembly of Membrane-Active Antimicrobial Polypeptides [0.03%]
具有抗菌活性的膜活性多肽的结构、相互作用及组装过程
Tzong-Hsien Lee,Patrick Charchar,Marc-Antoine Sani et al.
Tzong-Hsien Lee et al.
Antimicrobial peptides (AMPs) are emerging as potential antibacterial drugs in the face of rapidly increasing bacterial resistance to conventional antibiotics. These peptides target the microbial membrane, and numerous models are used to de...
Artificial Intelligence for Materials Science: Transforming Research Paradigms [0.03%]
材料科学的人工智能：变革研究范式
Yue Li,Shurui Wang,Jianping Wang et al.
Yue Li et al.
The evolution of materials science is undergoing a profound paradigm shift driven by artificial intelligence (AI), transitioning from traditional intuition-driven trial-and-error to an accelerated, data-centric, and algorithmically guided d...
Direct Electrochemistry of Hydrogenase, Formate Dehydrogenase, CO Dehydrogenase, and Nitrogenase: Wiring Strategies and Mechanistic Insights into Metalloenzymes That Produce Solar Fuels [0.03%]
氢化酶、甲酸脱氢酶、一氧化碳脱氢酶和固氮酶的直接电化学：用于产生太阳能燃料金属酶的接线策略及机理研究见解
Vincent Fourmond,Andrea Di Giuliantonio,Miriam Malagnini et al.
Vincent Fourmond et al.
Direct electrochemistry (DET), whereby a redox enzyme exchanges electrons with an electrode without the intervention of any mediator, has emerged at the turn of the XXIst century as a powerful tool to investigate redox enzymes. In this revi...
Programmable Anisotropy: From Mesophase Order to Functional Architectures [0.03%]
各向异性可编程性：从介观相序到功能架构
Jeremy Money,Seyed Mostafa Tabatabaei,Pattuwe A A L D Pattuwearachchi et al.
Jeremy Money et al.
Across biology, structural hierarchy converts bottom-up self-assembly into macroscopic function, yielding emergent mechanical, transport, and optical behaviors. Liquid crystals (LCs) are uniquely positioned in this realm by coupling fluidit...
Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease [0.03%]
周围神经蛋白22及其在Charcot-Marie-Tooth病中的重要性
Charles R Sanders,Bruce D Carter,Mason C Wilkinson et al.
Charles R Sanders et al.
Charcot-Marie-Tooth disease (CMT) is an often-debilitating peripheral neuropathy that is a top-10 most prevalent human genetic disorder. However, there is currently no effective treatment. Over half of diagnosed CMT cases in western populat...