Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics [0.03%]
利用肽模拟物和合成生物制剂应对不可成药靶点
Colin S Swenson,Gunasheil Mandava,Deborah M Thomas et al.
Colin S Swenson et al.
The development of potent, specific, and pharmacologically viable chemical probes and therapeutics is a central focus of chemical biology and therapeutic development. However, a significant portion of predicted disease-causal proteins have ...
Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals [0.03%]
分子探針行動記：基因编码的荧光生物传感器点亮细胞信号
Anneliese M M Gest,Ayse Z Sahan,Yanghao Zhong et al.
Anneliese M M Gest et al.
Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled the study of these signaling pathways in living systems across temporal and sp...
Yu Chen,Qianqian Zhen,Fan-Jie Meng et al.
Yu Chen et al.
Noncovalent interactions between a lone pair of electrons and π systems can be categorized into two types based on the nature of π systems. Lone pair-π(C═O) interactions with π systems of unsaturated, polarized bonds are primarily attr...
Christopher J Chang
Christopher J Chang
How to Assess and Predict Electrical Double Layer Properties. Implications for Electrocatalysis [0.03%]
如何评估和预测双电层性质及对电催化的影响
Christian M Schott,Peter M Schneider,Kun-Ting Song et al.
Christian M Schott et al.
The electrical double layer (EDL) plays a central role in electrochemical energy systems, impacting charge transfer mechanisms and reaction rates. The fundamental importance of the EDL in interfacial electrochemistry has motivated researche...
Noncanonical Amino Acid Tools and Their Application to Membrane Protein Studies [0.03%]
非天然氨基酸在膜蛋白研究中的应用工具及应用
Chiara De Faveri,Jordan M Mattheisen,Thomas P Sakmar et al.
Chiara De Faveri et al.
Methods rooted in chemical biology have contributed significantly to studies of integral membrane proteins. One recent key approach has been the application of genetic code expansion (GCE), which enables the site-specific incorporation of n...
Steven S Cheng,Alison C Mody,Christina M Woo
Steven S Cheng
O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-translational modification (PTM) found on serine and threonine residues of thousands of nucleocytoplasmic proteins. The installation and removal of O-Gl...
Moreno Wichert,Laura Guasch,Raphael M Franzini
Moreno Wichert
DNA-encoded library (DEL) technology is a powerful platform for the efficient identification of novel chemical matter in the early drug discovery process enabled by parallel screening of vast libraries of encoded small molecules through aff...
Vladimir Ladizhansky,Ravi Shankar Palani,Michael Mardini et al.
Vladimir Ladizhansky et al.
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly over the past three decades and established itself as a vital tool for the structural analysis of biological macromolecules and materials. This review del...
Guanglong Ding,Hang Li,JiYu Zhao et al.
Guanglong Ding et al.
The quest to imbue machines with intelligence akin to that of humans, through the development of adaptable neuromorphic devices and the creation of artificial neural systems, has long stood as a pivotal goal in both scientific inquiry and i...