Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein [0.03%]
从体内到体外：无细胞系统中的药物分子合成及非标准氨基酸的应用
Marco G Casteleijn,Ulrike Abendroth,Anne Zemella et al.
Marco G Casteleijn et al.
Throughout history, we have looked to nature to discover and copy pharmaceutical solutions to prevent and heal diseases. Due to the advances in metabolic engineering and the production of pharmaceutical proteins in different host cells, we ...
Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications [0.03%]
钒化合物的水解、配体交换及氧化还原性质：溶液转化在生物、治疗和环境应用中的意义
Rupam Dinda,Eugenio Garribba,Daniele Sanna et al.
Rupam Dinda et al.
Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment and in living beings. The different reactions that vanadium compounds (VCs) undergo in the presen...
Mi Peng,Chengyu Li,Zhaohua Wang et al.
Mi Peng et al.
Heterogeneous catalysts are pivotal to the chemical and energy industries, which are central to a multitude of industrial processes. Large-scale industrial catalytic processes rely on special structures at the nano- or atomic level, where r...
Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics [0.03%]
基于蛋白的降解剂：从化学生物学工具到新疗法
Lisha Ou,Mekedlawit T Setegne,Jeandele Elliot et al.
Lisha Ou et al.
The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to the broad application of TPD is its depe...
Zhuoran Long,Jinhui Meng,Lydia R Weddle et al.
Zhuoran Long et al.
The application of external electric fields to influence chemical reactions at electrode interfaces has attracted considerable interest in recent years. However, the design of electric fields to achieve highly efficient and selective cataly...
Synthetic Lipid Biology [0.03%]
合成脂质生物学
Po-Hsun Brian Chen,Xiang-Ling Li,Jeremy M Baskin
Po-Hsun Brian Chen
Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further,...
Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules [0.03%]
共价模板导向合成：构筑复杂分子的强大工具
Peter Bolgar,Mohit Dhiman,Diego Núñez-Villanueva et al.
Peter Bolgar et al.
Template-directed synthesis has become a powerful methodology to access complex molecules. Noncovalent templating has been widely used in the last few decades, but less attention has been paid to covalent template-directed synthesis, despit...
The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future [0.03%]
亚磺酰基胲腙的卡拜化学：过去、现在和未来
Xiaolong Zhang,Paramasivam Sivaguru,Yongzhen Pan et al.
Xiaolong Zhang et al.
N-Sulfonyl hydrazones have been extensively used as operationally safe carbene precursors in modern organic synthesis due to their ready availability, facile functionalization, and environmental benignity. Over the past two decades, there h...
Targeted Covalent Modification Strategies for Drugging the Undruggable Targets [0.03%]
不可成药靶点的靶向共价修饰策略
Tomonori Tamura,Masaharu Kawano,Itaru Hamachi
Tomonori Tamura
The term "undruggable" refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Druggi...
Kohei Kusada,Hiroshi Kitagawa
Kohei Kusada
Metal nanomaterials with unconventional phases have been recently developed with a variety of methods and exhibit novel and attractive properties such as high activities for various catalytic reactions and magnetic properties. In this revie...