TPP-Fabricated All-Fiber Nanoforce Sensor with Deep Learning Analysis Enables Ultrasensitive Cancer Cell Mechanophenotyping [0.03%]
基于TPP微纳加工的全光纤纳米力传感器及深度学习分析用于癌细胞机械表型的精准探测
Jianchen Xie,Shibang Li,Jingjing Li et al.
Jianchen Xie et al.
Cellular mechanics provide sensitive, quantitative markers of cancer progression, yet routine nanoforce measurements remain constrained by the cost, footprint, and electromagnetic limitations of conventional platforms. Here we report an all...
Unveiling Pathological Lipid Droplet Accumulation of Dopaminergic Neurons in Parkinson's Disease via a Super-Retentive Fluorescent Probe [0.03%]
一种超,retain型荧光探针用于揭示帕金森病多巴胺神经元病理脂质 droplets 积累现象
Chen Zhang,Sisi Ruan,Qixin Deng et al.
Chen Zhang et al.
Lipid droplets are highly dynamic organelles in nerve cells and are essential for the function of the central nervous system. The abnormal accumulation of lipid droplets in dopaminergic neurons, found in Parkinson's disease (PD) cells and a...
Characterizations of G-Quadruplex RNA-Protein Interactions in Living Cells [0.03%]
活细胞中G-四链体RNA-蛋白质相互作用的表征
Feng Tang,Xiaochen Liang,Douglas F Porter et al.
Feng Tang et al.
RNA guanine quadruplexes (rG4s) are noncanonical nucleic acid structures that contribute to diverse cellular functions and disease mechanisms. Defining the proteins that interact with rG4s (rG4IPs) is essential for elucidating their biologi...
ValveCCI-seq: An Advanced Microfluidic Approach for Deciphering Cell-Cell Interactions [0.03%]
阀值cci-seq：一种解码细胞相互作用的微流控先进技术
Mingsheng Wang,Jingyu Qi,Shiyu Wang et al.
Mingsheng Wang et al.
Immunotherapy eliminates diseased cells by precisely activating or enhancing the patient's immune responses, with its efficacy critically dependent on the accurate modulation of immune cell interaction networks with disease-relevant targets...
Listening to Cellular Whispers through Glycosphingolipids: A Comprehensive Review of Recent Advancements in Glycosphingolipid Analysis and Annotation [0.03%]
聆听细胞低语：基于糖脂分析与鉴定的近期研究综述
Amirreza Dowlati Beirami,Evelyn Rampler
Amirreza Dowlati Beirami
Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Cross-Links: Formation and Repair in Human Cells [0.03%]
人细胞中甲基乙二醛DNA-蛋白质交联的同位素稀释NanoLC-MS/MS定量：形成和修复
Reinner O Omondi,Elijah M Barnes,Krishna C Gurajala et al.
Reinner O Omondi et al.
DNA-protein cross-links (DPCs) represent a prevalent form of DNA damage that forms when cellular proteins become covalently trapped to DNA strands upon exposure to various endogenous and exogenous agents. Methylglyoxal is an endogenous meta...
Triangulation of Guest Species in Porous Frameworks Using Solid-State NMR Spectroscopy and Quantum Chemical Calculations [0.03%]
基于固态核磁共振光谱和量子化学计算的多孔材料中客体分子的定位研究
Joseph Hurd,Yujie Ma,Martin Schröder et al.
Joseph Hurd et al.
Porous functional materials, such as zeolites and metal-organic frameworks (MOFs), are invaluable to chemical industries due to their high surface areas and chemical versatility. Understanding how the active sites of these materials interac...
Rigidity-Responsive Fluorescence Polarization Detection of Aflatoxin B1 via Programmable RCA-Coupled CRISPR/Cas12a and a Conformation-Restricted Depolarization Reporter [0.03%]
基于编程环形探针扩增的CRISPR / Cas12a和构象限制解旋报告基因的 rigidity-responsive荧光偏振检测黄曲霉毒素B1
Jia Zhao,Zhuqi Sui,Yu Zhou et al.
Jia Zhao et al.
Aflatoxin B1 (AFB1) is one of the most toxic and carcinogenic mycotoxins, and its trace-level determination in complex food matrices remains a major analytical challenge. Conventional chromatographic methods, while highly accurate, rely on ...
Precise Artificial Intelligence Nanomotor Tracking-Powered Amplification-Free Digital MicroRNA Sensing [0.03%]
基于精确人工智能纳米电机跟踪的放大数字微RNA传感技术
Jingjing Shi,Zuhua Yu,Hui Tian et al.
Jingjing Shi et al.
Digital assays have become a state-of-the-art technology for the sensing of nucleic acid molecules. Nevertheless, most of the prevalent digital nucleic acid assays heavily rely on sealed microchambers and sophisticated nucleic acid amplific...
Hydrogel RT-LAMP Enables Rapid, Quantitative Assessment of Mycobacterium tuberculosis Immune Responses [0.03%]
水凝胶RT-LAMP使结核分枝杆菌免疫反应的快速定量评估成为可能
Jidong Wang,Min Yang,Xi Lu et al.
Jidong Wang et al.
Tuberculosis (TB) remains a global health challenge, requiring rapid and accessible diagnostics to guide preventive therapy. C-X-C motif chemokine ligand 10 (CXCL10) mRNA is a promising biomarker of TB infection, yet current assays rely on ...