HematoCARD: A Volumetric Duplicate Dried Blood Spot Collection Cartridge Validated for Therapeutic Drug Monitoring [0.03%]
HematoCARD：一种用于治疗药物监测的体积复制干血斑收集卡匣
Lorenz Van Hileghem,Dries Vloemans,Francesco Dal Dosso et al.
Lorenz Van Hileghem et al.
The growing global demand for in vitro diagnostic testing requires the resource-intensive, centralized healthcare system to convert to a more decentralized, patient-centric model. In this context, patient-centric sampling through dried bloo...
Design of Highly Sensitive Plasmonic Nanocavities and the Application in Trace Detection of Chromium (VI) Ion [0.03%]
一种高灵敏度等离激元纳腔的设计及在痕量六价铬离子检测中的应用研究
Xiaotian Wang,Wuliji Hasi,Shuang Lin et al.
Xiaotian Wang et al.
The development of plasmonic nanocavities with high structural complexity is essential for various applications, particularly for SERS sensing, where their powerful electromagnetic field confinement capabilities enable efficient optical sig...
Study of the Aggregation Behavior of Proteins Related to Neurodegenerative Diseases Based on the Photoluminescence of Perovskite Nanocrystals [0.03%]
基于钙钛矿纳米晶体光致发光的神经退行性疾病相关蛋白质聚集行为研究
Yizhu Wang,Mengxiao Lv,Wenxiu Zhu et al.
Yizhu Wang et al.
Neurodegenerative diseases (NDs) are closely associated with abnormal protein aggregation. In this study, SiO2-coated CsPbBr3 nanocrystals (CPB NCs) were exploited as label-free photoluminescence (PL) probes to investigate the aggregation b...
Label-Free Probes and Magneto-Thermal Imprinting Enable Rapid Multiplexed Exosomal Profiling for Breast Cancer Classification [0.03%]
无标签探针和磁热印迹技术实现乳腺癌快速多重外泌体谱型分析及分类
Linghao Zhao,Shi-Yi Zhang,Zeyu Wu et al.
Linghao Zhao et al.
Exosomes, characterized by abundant membrane proteins and high structural stability, have emerged as crucial biomarkers for liquid biopsy. However, conventional exosome isolation and detection methods have limited their clinical applicabili...
ZNGEA: ZINB-NMF Integrated Graph Embedding Autoencoder for Metabolite-Disease Association Identification [0.03%]
基于ZINB-NMF的图嵌入自编码模型用于代谢物-疾病关联识别
Qiao Ning,Yanpeng Liu,Shaohang Qiao et al.
Qiao Ning et al.
Metabolism, a series of complex and orderly chemical reactions within a biological organism, has a significant impact on sustaining life activities. Disease development is often linked to alterations in the types or levels of metabolites; h...
Derivatization-Mediated MALDI-MSI and CE-LIF for Collaborative Analysis of Monosaccharides in Endometrial Cancer Patients: From Pathological Tissues to Serum [0.03%]
用于子宫内膜癌患者糖类分析的衍生化MALDI-MSI和CE-LIF技术：从病理组织到血清
Jingtong Xia,Yanxia Zhang,Tao Wang et al.
Jingtong Xia et al.
Abnormal glucose metabolism has been identified as a key characteristic of tumorigenesis. Visualizing the levels of monosaccharides in the lesion tissues and bodies of cancer patients is conducive to uncovering patterns of glucose metabolic...
Reaction Kinetics of CRISPR trans-Cleavage Controlled Using Isotachophoresis [0.03%]
等速电泳控制的CRISPR反式切割反应动力学研究
Qi Jiang,Ashwin Ramachandran,Alexandre S Avaro et al.
Qi Jiang et al.
CRISPR-based diagnostics are powerful tools for nucleic acid detection due to their high specificity and programmability. However, assay sensitivity is often limited by the slow kinetics of the trans-cleavage reaction, which typically proce...
Variability in the Universality of Electron Ionization Mass Spectrometry Response to Oxygenates in Complex Environmental Mixtures [0.03%]
复杂环境混合物中氧合物的电子离子化质谱响应的普遍性变异
Purushottam Kumar,Chenyang Bi,Brian Lerner et al.
Purushottam Kumar et al.
Electron ionization mass spectrometry (EIMS) has been widely used to measure complex atmospheric and environmental mixtures. The sensitivity of analytes in EIMS is typically obtained through a multipoint calibration curve using commercially...
xcms in Peak Form: Now Anchoring a Complete Metabolomics Data Preprocessing and Analysis Software Ecosystem [0.03%]
XCMS大显身手：代谢组学数据预处理及分析软件生态系统构建者
Philippine Louail,Carl Brunius,Mar Garcia-Aloy et al.
Philippine Louail et al.
High-quality data preprocessing is essential for untargeted metabolomics experiments, where increasing data set scale and complexity demand adaptable, robust, and reproducible software solutions. Modern preprocessing tools must evolve to in...
A Dual-Signal Amplification Detection of Tumor mRNA Vaccines Based on the Novel Full-Length Catalytic Loop Initiating DNAzyme [0.03%]
一种基于全长催化环引发DNAzyme的肿瘤mRNA疫苗双信号放大检测法
Miao He,Han Pan,MuRilege Chao et al.
Miao He et al.
The potential of mRNA vaccines, in the field of tumor treatment, has gradually emerged. With the development of mRNA vaccines, monitoring their levels has become particularly important. In this part of the work, a novel dual signal amplific...