DuReS: An R Package for Denoising Experimental Tandem Mass Spectra and Metabolite Annotation [0.03%]
杜瑞斯：一个用于去噪和注释代谢物的质谱R包
Shayantan Banerjee,Prajval Nakrani,Aviral Singh et al.
Shayantan Banerjee et al.
Mass spectrometry-based untargeted metabolomics is a powerful technique for profiling small molecules in biological samples, yet accurate metabolite identification remains challenging. The presence of random noise peaks in tandem mass spect...
Nanoflow Size Exclusion Chromatography-Native Mass Spectrometry of Intact Proteoforms and Protein Complexes [0.03%]
纳米流动相排阻色谱-蛋白质整体形式和蛋白复合物的原位质谱分析
Ziran Zhai,Thomas Holmark,Annika A M van der Zon et al.
Ziran Zhai et al.
Native size-exclusion chromatography (SEC) coupled with native mass spectrometry (nMS) enables the characterization of proteins and protein complexes by combining liquid-phase separation (SEC) and mass measurement (nMS). This approach allow...
MSI-Explorer: Napari-Powered Tool for Mass Spectrometry Imaging Data Analysis [0.03%]
MSI-Explorer：用于质谱成像数据分析的Napari插件工具
Nay Min Min Thaw Saw,Lennart Kowitz,Peter Lampen et al.
Nay Min Min Thaw Saw et al.
Mass spectrometry imaging (MSI) enables label-free spatial localization of biomolecules from single cells to whole tissues, making it a key technology in the growing fields of spatial omics. However, a lack of comprehensive open-source tool...
High-Throughput HPLC Method for the Measurement of Octanol-Water Partition Coefficients without an Organic Modifier [0.03%]
不含有机改性剂测定辛醇/水分配系数的高效液相色谱法
Jonathan Rains,Elliot Steeples,Ben Robinson et al.
Jonathan Rains et al.
We present a high-performance chromatographic method for the determination of octanol-water partition coefficients of organic molecules, suitable for pharmaceuticals, agrochemicals, and fine-chemicals featuring acidic and basic pKa values. ...
Ratiometric Optical Sensing of Aerosol Phase State with Excited-State Intramolecular Proton Transfer Probes [0.03%]
利用激发态分子内质子转移探针比值型光学检测气溶胶相态
Angel M Gibbons,Paul E Ohno
Angel M Gibbons
Phase transitions in respiratory and environmental aerosols impact critical processes ranging from virus transmission to atmospheric light scattering. Yet, small particle sizes and low mass densities in air make experimental measurements of...
Discovery of Environment-Sensitive Near Infrared SHP2-Targeting Fluorescent Ligands for Living Cells and Tissue Section Imaging [0.03%]
用于活细胞和组织切片成像的环境敏感型近红外SHP2靶向荧光配体的发现
Dong Liang,Chen Yu,Yan Lan et al.
Dong Liang et al.
SHP2 protein, a nonreceptor type protein tyrosine phosphatase, is a crucial signal transduction regulator. It interacts with key signaling molecules in the RAS/ERK and PD-1/PD-L1 pathways and significantly affects cell proliferation, differ...
A Rapid Electrochemical DNA Biosensor for Serum Uric Acid Using the Pre-equilibrium Binding Mechanism [0.03%]
利用预平衡结合机制的快速电化学DNA生物传感器检测血清尿酸
Zhenglian Li,Ge Gao,Yanguan Lv et al.
Zhenglian Li et al.
The precise and rapid detection of uric acid (UA) in human serum is pivotal for diagnosing and managing metabolic disorders such as gout, kidney disease, and hyperuricemia. However, current equilibrium-based assays suffer from long incubati...
Dual-Targeting Ratiometric Fluorescent Probe for Visualizing Changes in HClO and Polarity in Lipid Droplets and Mitochondria [0.03%]
一种双标记比率型荧光探针用于可视化检测脂滴和线粒体中次氯酸和极性变化
Chengcheng Sun,Zhiming Gou,Mei Yan et al.
Chengcheng Sun et al.
Cuproptosis is a mode of cell death caused by the accumulation of copper ions and involves mitochondrial dysfunction. Changes in the hypochlorous acid (HClO) content and polarity in cells are closely associated with many diseases and are in...
A DNA Data Storage System Using Electrochemically Active Non-natural Oligonucleotides with Flexible Microfluidic Chips [0.03%]
一种使用电化学活性非天然寡核苷酸和可变形微流控芯片的DNA数据存储系统
Jiankai Li,Ziyan Wang,Leni Zhong et al.
Jiankai Li et al.
Introducing non-natural oligonucleotides can provide DNA as a data storage medium with higher storage density and novel data storage paradigms. In particular, electrochemically active non-natural oligonucleotides can be detected through ele...
Light-Addressable Regenerative Photoelectrochemical Biosensor Array with Self-Calibration for High-Throughput and Accurate Detection of Circulating Tumor Cells [0.03%]
一种高通量和精确检测循环肿瘤细胞的自校准光地址再生光电化学生物传感器阵列
Zhaopeng Liu,Jian Li,Liming Gao et al.
Zhaopeng Liu et al.
High-efficiency detection of circulating tumor cells (CTCs) provides real-time information for cancer diagnosis and therapy. The light-addressable photoelectrochemical biosensor array (LAPECBA) is the best candidate for rapid and high-throu...