Highly Catalytic FeS2@CoS2 Core/Shell Nanocubes for Ultrasensitive Electrochemical Assay of Microphthalmia-Associated Transcription Factor via Nucleic Acid Signal Amplification Cascades [0.03%]
高度催化的FeS2@CoS2核壳纳米立方体通过核酸信号放大级联对微小眼相关转录因子进行超灵敏电化学分析
Jianmei Yang,Qianhong Chen,Ruo Yuan et al.
Jianmei Yang et al.
Dysregulation expression of microphthalmia-associated transcription factor (MITF), a principal melanocyte controller, has been closely linked to melanin-associated disorders, and developing highly sensitive MITF detection methods is therefo...
A Streamlined Sequential Enrichment Strategy for Multi-PTM Profiling from Low Micrograms of Samples [0.03%]
一种针对低微克样品的多PTM谱分析的简化顺序富集策略
Geyi Zheng,Ling Zhao,Mingxiu Liang et al.
Geyi Zheng et al.
Post-translational modifications (PTMs) are critical regulators of protein function and are involved in many human diseases. However, comprehensive analysis of multiple PTM types from limited biological material remains a significant challe...
A Deep Learning Model for Efficient Nontargeted Screening of New Psychoactive Substances with Benchtop Nuclear Magnetic Resonance Devices [0.03%]
一种深度学习模型 可利用台式核磁设备高效筛选新型 psychoactive物质
Pengfei Liu,Wei Jia,Cuimei Liu et al.
Pengfei Liu et al.
Benchtop nuclear magnetic resonance (NMR) devices enable rapid on-site detection of new psychoactive substances (NPS) at customs or mobile checkpoints, addressing the urgent need for real-time screening in combating illicit drug trafficking...
Application and Prospects of Large Language Models in Small-Molecule Drug Discovery [0.03%]
大型语言模型在小分子药物发现中的应用与前景
Jin Ma,Jia Liu,Dongyu Xu et al.
Jin Ma et al.
An All-in-One Microfluidic Platform Synergizing Hybrid Dean/Herringbone Vortex Mixing with Magnetophoretic Sorting for Efficient EV Isolation and Multiplexed Biomarker Profiling [0.03%]
一种集多功能于一体化的微流控平台结合杂交德安/鱼骨涡旋混合与磁动力学分拣用于高效的外泌体分离和多重生物标志物分析
Xiaofeng Chen,Dongdong Zhang,Chanyu Yao et al.
Xiaofeng Chen et al.
Extracellular vesicles (EVs) have emerged as promising targets for liquid biopsy, yet their efficient isolation and release remain technically challenging. Conventional affinity-based microfluidic chips often suffer from limited contact eff...
Two-Dimensional Graphene-Based Chemically Modified Electrochemical and Photoelectrochemical Sensors for Antibiotic Detection [0.03%]
用于抗生素检测的二维石墨烯化学修饰电化学和光电化学传感器
Jamil A Buledi,Sergii Golovynskyi,Junle Qu et al.
Jamil A Buledi et al.
HDSE-MS: Tandem Mass Spectrum Prediction for Small Molecules via Hierarchical Distance Structural Encoding [0.03%]
基于分层距离结构编码的小分子串联质谱预测（HDSE-MS）
Zhangqiang Liu,Bingyi Wang,Congcong Yang et al.
Zhangqiang Liu et al.
Tandem mass spectrometry (MS/MS) is a core technology for small molecule structural elucidation in nontargeted metabolomics. However, the limited coverage of experimental spectral libraries presents a major challenge to MS-based small molec...
Selection of Allosteric DNAzymes for Theophylline Sensing by Expression-SELEX [0.03%]
基于表达的SELEX筛选用于咖啡因检测的 allosteric DNAzyme传感器
Binfen Chen,Yinghong Lin,Huixin Chen et al.
Binfen Chen et al.
Aptamers are single-stranded DNA or RNA molecules that bind specific ligands with high affinity. DNA aptamers are especially promising due to their enhanced stability and cost-effectiveness, yet their practical use often necessitates coupli...
GPMassSimulator: A Graphormer-Based Method for Glycopeptide MS/MS Spectra Prediction [0.03%]
基于图变换器的糖肽MS/MS谱图预测方法GPMassSimulator
Yihui Ren,Dongbo Bu,Bo Duan et al.
Yihui Ren et al.
Protein glycosylation is a critical post-translational modification involved in numerous biological processes and disease states. While mass spectrometry has emerged as the primary tool for glycoproteomics analysis, the structural complexit...
Machine Learning-Guided Optimization of SABRE Hyperpolarization for α-Ketoglutarate in Acetone-Water [0.03%]
机器学习指导的α-酮戊二酸乙腈-水溶液中SABRE超极化优化
Erica Curran,Sina Sadeghi,Stephen J McBride et al.
Erica Curran et al.
Signal amplification by reversible exchange (SABRE) is a hyperpolarization method that polarizes target nuclei of metabolites quickly and efficiently. Recent SABRE advances, including Ace-SABRE, yield biocompatible, aqueous solutions of hyp...