A Portable Smartphone Platform for Onsite Diphenyl Phosphate Detection Enabled by Dual-Signal Molecularly Imprinted Nanozymes [0.03%]
一种便携式智能手机平台通过双信号分子印迹纳米酶实现现场检测二苯基磷酸盐
Na Li,Xiaoxiao Zhang,Jincheng Zhang et al.
Na Li et al.
Concerns regarding the environmental and health risks associated with diphenyl phosphate (DPhP) have prompted the development of sensitive, selective, and cost-effective analytical methods for its detection. In this study, we introduce a no...
One-Step Chemiluminescent Immunoassay for the Key Synthesis Protein of Ochratoxin A Using a Shark Single-Domain Antibody-Alkaline Phosphatase Fusion Protein [0.03%]
一种使用鲨鱼单域抗体-碱性磷酸酶融合蛋白的一步化学发光免疫分析法检测赭曲霉毒素A关键合成蛋白
Zheming Wang,Zhenyun He,Xiaoxia Xie et al.
Zheming Wang et al.
Basic leucine zipper (BZIP) proteins constitute one of the largest and most diverse families of transcription factors and play a crucial role in OTA biosynthesis by regulating the expression of genes within the biosynthetic gene cluster. As...
A Primer Exchange Reaction-Based Multidimensional AND-Gated Molecular Classifier [0.03%]
基于交换反应的多维分子AND门分类器
Yuanhao Wang,Yuxuan Wu,Zhe Liu et al.
Yuanhao Wang et al.
Integrated sensing and intelligent interpretation of multidimensional biomarkers are essential for the in-depth characterization of complex biological microenvironments. Here, we developed an integrated AND-gated molecular classifier based ...
Epitope-Directed Antibody Development and Enhancement for Broad-Spectrum Fentanyl-Class Substance Detection: From Rational Hapten Design to On-Site Analysis [0.03%]
针对宽谱芬太尼类物质检测的抗体开发及优化：从理性抗原设计到现场分析
Xiaoyi Chen,Xiang Chi,Yuxi Hu et al.
Xiaoyi Chen et al.
The abuse of fentanyl and its analogues poses a severe threat to public health, making the development of robust detection tools crucial for effective surveillance. However, the whole category control of fentanyl makes it tough to monitor a...
Integrated Microfluidic SERS Sensor Featuring Au NPs@Cu MOF/Hydrogel for Label-Free and Specific Creatinine Detection [0.03%]
一种基于AuNPs@铜MOF/水凝胶的集成微流体SERS传感器用于无标记特异性肌酐检测
Xinyue Peng,Jiaying Cao,Chang Chen et al.
Xinyue Peng et al.
Creatinine is a critical biomarker for assessing renal function, and its accurate detection is essential for early diagnosis of kidney diseases. However, real-time and label-free specificity creatinine sensing remains challenging. Herein, w...
Enhancing Vibrational Spectroscopy-Based Diagnosis through Bottom-Up Modeling: The Case of Infrared Absorption Spectrum of Urine [0.03%]
基于从下到上模型的振动光谱诊断的增强——以尿液红外吸收光谱为例
Víctor Navarro-Esteve,Ángel Sánchez-Illana,José Portolés et al.
Víctor Navarro-Esteve et al.
Vibrational spectroscopy has become a valuable tool for biomedical applications. However, the technique generates large empirical spectral data sets, requiring multivariate analysis using an ever-evolving arsenal of machine learning approac...
Correction to "Built-In Electric Field-Assisted Enzyme Catalytic Amplification with ZnO/CIS Heterojunctions for Photoelectrochemical Immunoassay" [0.03%]
关于“基于ZnO/CIS异质结内置电场增强的酶催化放大光电免疫检测”的更正通知
Haiyang Wang,Mingdi Xu,Di Wu et al.
Haiyang Wang et al.
Published Erratum
Analytical chemistry. 2026 Apr 17. DOI:10.1021/acs.analchem.6c01705 2026
Decoding the Oxylipin Chemical Space Using Ion Identity Molecular Networking [0.03%]
利用离子身份分子网络解码氧脂质化学空间
Sandra M Camunas-Alberca,Francesco Bartolini,Hana Cermakova et al.
Sandra M Camunas-Alberca et al.
Oxylipins are bioactive lipid mediators that play key roles in biological and pathological processes. Their remarkable chemical diversity makes their identification by untargeted LC-MS/MS analyses challenging. To date, effective solutions f...
Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry [0.03%]
基于声学喷射的高通量无标记CYP3A4抑制剂筛选方法
Mary Ashley Rimmer,Jingheng Wang,Tharindu A Ranathunge et al.
Mary Ashley Rimmer et al.
Label-free high-throughput screening (HTS) technologies have greatly accelerated early drug discovery by allowing direct measurement of biochemical activity without the need for chemical labels. Techniques like MALDI-TOF, RapidFire, desorpt...
Dual-Lock NIR Dual-Channel Probe: Synchronous Viscosity/HSO3- Sensing for Visualizing Platinum-Induced Nephrotoxicity and Renoprotector Screening [0.03%]
双锁定NIR双通道探针：同步粘度/HSO3-检测用于可视化铂引起的肾毒性和肾脏保护剂筛选
Siyu Gao,Lulu Zhang,Wenwen Li et al.
Siyu Gao et al.
Platinum-based anticancer agents are extensively used in clinical chemotherapy but often cause severe nephrotoxicity, which limits their clinical utility. To address this critical challenge, we designed and validated two benzothiazole-deriv...