Lysosome-Targeted Si-rhodamine Derivative for NO Imaging in Mice Brain with Neurological Diseases [0.03%]
靶向溶酶体的Si-rhodamine衍生物在神经疾病小鼠脑内成像检测NO浓度分布
Kunyi Wang,Jiaying Zhou,Yujie Geng et al.
Kunyi Wang et al.
Nitric oxide (NO) is an intracellular and intercellular messenger, regulating cellular functions in different manners. Intracellular vesicular acidic compartments, such as lysosomes, are essential digestive organelles of the cells, where th...
Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope [0.03%]
基于混合拉曼和部分波光谱显微镜的胃肠癌化田地研究
Elena Kriukova,Mikhail Mazurenka,Sabrina Marcazzan et al.
Elena Kriukova et al.
Field cancerization (FC) refers to spatially distributed premalignant tissue changes that lead to the appearance of local malignancy, and its detection can improve cancer screening. In this work, we employ combined Raman and partial wave sp...
Time-Gated Raman Spectroscopy Combined with Deep Learning for Rapid, Label-Free Histopathological Discrimination of Gastric Cancer [0.03%]
结合深度学习的时间门控拉曼光谱学在胃癌无标记组织病理鉴别中的快速应用研究
Yafei Shi,YanQi Wang,Xiang Li et al.
Yafei Shi et al.
Gastric cancer is one of the most common malignant tumors of the digestive system, with a high mortality rate due to late-stage diagnosis. Current clinical diagnosis relies on endoscopic biopsy and histopathological analysis, which are high...
Enhancing Sensitivity in Low-Load Proteomics Orbitrap Workflows via SLIM Integration [0.03%]
通过SLIM整合提高低负载蛋白质组轨道阱工作流程的灵敏度
Liulin Deng,Brian Adamson,Alan McKenzie-Coe et al.
Liulin Deng et al.
A Structures for Lossless Ion Manipulation-Orbitrap Exploris 480 (SLIM-OE) ion mobility mass spectrometry (IM-MS) platform was developed, integrating SLIM IM separation with Orbitrap MS analysis. A "staggered IMS" mode was designed to acqui...
Multilevel Discrete Wavelet Decomposition-Assisted Lightweight Multi-Order Gated Aggregation Network for Gas Concentration Retrieval in WMS [0.03%]
一种基于多阶门控聚合网络的轻量级气体浓度反演方法
Zhengzhuo Li,Pengpeng Wang,Zhanshang Su et al.
Zhengzhuo Li et al.
This paper presents a lightweight multigated aggregation network assisted by multilevel discrete wavelet decomposition (MDWD-LiteMogaNet) for gas detection in wavelength modulation spectroscopy (WMS). By integration of the wavelet transform...
Protein Resistance Driven by Crosslinked Biorecognition Layer for a Win-Win Analysis of the Immunoassay in Urine [0.03%]
交联生物识别层驱动的蛋白质抗性尿免疫分析双赢策略
Junhao Chen,Siyu Chen,Yafei Lou et al.
Junhao Chen et al.
Currently, biosensor antifouling and biorecognition layer designs are considered apart. The antifouling layer unavoidably impairs the electrochemical link between the biorecognition layer and base electrodes, resulting in a double-edged ant...
Analytical Data Review on an Artificial Intelligence Platform for Doping Control in Horse Racing [0.03%]
赛马兴奋剂控制的人工智能平台的分析数据审查
Chun Sing Lai,April S Y Wong,Kin-Sing Wong et al.
Chun Sing Lai et al.
In the screening of prohibited substances (PS) in horse biological samples with gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) for doping control, an enormous number of chromatograms are gen...
The Structural Fingerprint of Therapeutic Monoclonal Antibodies Determined Using a Combination of Near-UV Circular Dichroism and Statistical Approach for Comparative Analysis [0.03%]
基于近紫外圆二色光谱和统计方法组合测定的药物单克隆抗体二级结构指纹图谱
Masato Kiyoshi,Taiji Oyama,Hiroko Shibata et al.
Masato Kiyoshi et al.
The higher-order structure (HOS) of therapeutic monoclonal antibodies is one of the important quality characteristics in terms of efficacy and safety. However, the HOS of therapeutic monoclonal antibodies has been assessed using low- to med...
Unveiling the Inverse-Handed Self-Discrimination of Helicenes with Twisted π-Surfaces by Liquid Chromatography [0.03%]
手性色谱法研究螺旋烯螺旋方向与扭转π表面构效关系
Eisuke Kanao,Yasuo Murata,Sorachi Miwa et al.
Eisuke Kanao et al.
Helicenes, with their rigid, helically twisted π-conjugated backbones, have garnered growing attention as potential chiral selectors, yet their capabilities for enantioselective molecular recognition remain largely unexplored. In this stud...
Quantitative Near-Infrared Photoacoustic Imaging of Gamma-Glutamyl Transpeptidase Activity in Tumors [0.03%]
基于近红外光声成像的小鼠肿瘤γ-谷氨酰转肽酶活性定量检测研究
Yueyan Yang,Rui Wang,Xinrun Jin et al.
Yueyan Yang et al.
Gamma-glutamyl transpeptidase (GGT) is essential for glutathione metabolism and is overexpressed in many cancers, making its sensitive and quantitative detection crucial for early cancer diagnosis. However, existing imaging strategies often...