Spectroelectrochemical Fiber-Optic Sensor Based on Localized Surface Plasmon Resonance for Simultaneous Multiselective Electroactive Species Detection [0.03%]
基于局域表面等离子共振的光纤电化学传感器用于同时多选择性地检测活性电化学物质
Tatsuya Orii,Takuya Okazaki,Takamichi Yamamoto et al.
Tatsuya Orii et al.
Herein, we report the development of a novel sensor combining electrochemistry, localized surface plasmon resonance (LSPR) in nanoparticles, and fiber-optic sensing for the first time. The sensor developed comprises an indium tin oxide (ITO...
Evaporation-Generated Dense Hotspots on Superwettable Patterned Microchips for Multiplex SERS Detection of Acute Myocardial Infarction-Specific miRNAs [0.03%]
超亲水微图案芯片上蒸发驱动的密集型热点用于急性心肌梗死特异性miRNAs的多次表面增强拉曼光谱检测
Hongxiao Gao,Jing Xu,Manyan Wu et al.
Hongxiao Gao et al.
Acute myocardial infarction (AMI) poses a threat to human health, and current clinical diagnostic methods cannot achieve early warning of AMI. The accurate detection of AMI-specific miRNAs is of great significance for the early diagnosis an...
Antifouling Capture and Dual-Targeting Recognition-Induced Signal Amplification for Triple-Mode Detection and Identification of Circulating Tumor Cells [0.03%]
兼具捕获和双重靶向识别放大信号的多重抗污策略用于循环肿瘤细胞的三模式检测与鉴定
Xinmei Wang,Han Lv,Jinxin Men et al.
Xinmei Wang et al.
Circulating tumor cells (CTCs) are promising biomarkers for cancer diagnosis, while detecting CTCs in clinical samples is still challenging due to the scarcity and heterogeneity of CTCs. Herein, a triple-mode sensing platform based on an an...
Microdroplet Accelerating C(sp2)-H Halogenation in Organic, Pharmaceutical, Analytical, and Environmental Use [0.03%]
微滴加速有机、药物、分析和环境中的C(sp2)―H卤化反应
Shengkai Chen,Jiannan Sun,Hongmei Hu et al.
Shengkai Chen et al.
Microdroplet chemistry is continuously attracting extensive interest from scientific communities because of striking properties (acceleration, redox, extreme pHs, etc.). Despite the vast majority contributing to reactions of polar compounds...
Single-Cell Multiomic MALDI-MSI Analysis of Lipids and N-Glycans through Affinity Array Capture [0.03%]
基于亲和阵列捕获的单细胞多组学基质辅助激光解吸电离质谱成像分析脂肪酸和N-糖链
James W Dressman,Muhammed F Bayram,Peggi M Angel et al.
James W Dressman et al.
This study presents a novel approach utilizing matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) for rapid single-cell analysis, enabling multiomic data acquisition from the same cell. Previously, single-cell...
Multivariate and Machine Learning-Derived Virtual Staining and Biochemical Quantification of Cancer Cells through Raman Hyperspectral Imaging [0.03%]
基于拉曼超光谱成像的多元和机器学习派生虚拟染色及癌细胞生物化学定量分析
Vikas Yadav,Ruchi Singh,Maya Chaturvedi et al.
Vikas Yadav et al.
Advances in virtual staining and spatial omics have revolutionized our ability to explore cellular architecture and molecular composition with unprecedented detail. Virtual staining techniques, which rely on computational algorithms to map ...
The Critical Need for Implementing RRF in the Accurate Assessment of Impurities in Peptide Therapeutics [0.03%]
RRF在肽类药物杂质精准评估中的实施需求分析
Akhilesh Kumar Kuril
Akhilesh Kumar Kuril
The Relative Response Factor (RRF) is a critical parameter in the quantification of impurities in peptides and other pharmaceutical substances, particularly during High-Performance Liquid Chromatography (HPLC) analysis with UV detection. Im...
Robust Multiclass Feature Selection for the Authentication of Honey Botanical Origin via Nontargeted LC-MS Analysis [0.03%]
基于非目标LC-MS分析的蜂蜜植物来源鉴定的鲁棒多分类特征选择方法研究
Shawninder Chahal,Lei Tian,Shaghig Bilamjian et al.
Shawninder Chahal et al.
Honey is one of the most frequently frauded foods due to the high market price of certain kinds of monofloral honey. Traditional authentication methods involving pollen or targeted analysis have limitations that can be manipulated by frauds...
Electrochemical Calcite-Assisted Localization and Kinetics (E-CLocK) Microscopy [0.03%]
电化学文石辅助定位与动力学（E-CLocK）显微镜技术
Ivani Jayalath,Shubhendra Shukla,Govinda Anantha Padmanabha et al.
Ivani Jayalath et al.
Nanoparticle (NP) morphology is a critical factor influencing the efficiency and selectivity of electrochemical reactions. However, conventional electrochemical techniques do not provide information about the dynamic morphological changes o...
Application of a Multiomics Imaging Workflow to Explore Asparlas Treatment in Solid Tumors [0.03%]
多组学成像工作流程在实体瘤中探索阿斯巴拉斯治疗的应用
Laura van der Vloet,Ronny Mohren,Christophe Bouillod et al.
Laura van der Vloet et al.
In acute lymphoblastic leukemia (ALL), hypermethylation of the asparagine synthetase (ASNS) gene promoter, leading to low levels of ASNS in tumor cells, is recognized as a prognostic biomarker, and l-asparaginase-based treatments (e.g., Asp...