Machine Learning-Driven Optimization of Viscoelastic Microfluidic Particle Separation [0.03%]
基于机器学习的微流控粘弹性粒子分离优化
Qing Lu,Zhuoran Zhao,Zhinan Zhang et al.
Qing Lu et al.
Viscoelastic microfluidics (VEM) offers superior biological particle isolation but is hindered by complex dynamics necessitating laborious empirical optimization. To address this challenge, we propose a machine learning (ML)-driven strategy...
Peroxynitrite-Activated Valproic Acid Precursor for Monitoring Oxidative Stress and Reducing Epileptic Seizures in an Epilepsy Model [0.03%]
一种丙戊酸前药用于监测癫痫模型中的氧化应激并减少癫痫发作
Kang Li,Haidong Li,Jinliang Han et al.
Kang Li et al.
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, which poses a significant threat to human health. Increasing evidence indicates that the pathological mechanism of epilepsy is closely related to the presence ...
Rapid and Specific Detection of Gastric Cancer EVs Using a Cas12a-Powered Aptasensor with a Novel Targeting Aptamer [0.03%]
基于新型靶向适配体的Cas12a驱动型核酸传感器快速灵敏检测胃癌外泌体
Gaojian Yang,Yile Fang,Yuan Liu et al.
Gaojian Yang et al.
Gastric cancer remains a predominant contributor to global cancer-related mortality, characterized by a pronounced disparity in five-year survival rates between early stage (>90%) and advanced-stage (
Fragmentation Pathways and Enhanced Detection Sensitivity of OH-PBDEs via LC-ESI-MS2: A Comprehensive Analytical Investigation [0.03%]
液相色谱-串联质谱法测定多溴代二苯基 ethers羟基衍生物的碎裂途径和增强检测灵敏度研究
Bairong Fu,Dongqin Tan,Jing Jin et al.
Bairong Fu et al.
The fragmentation behavior of isomeric hydroxylated polybrominated diphenyl ethers (OH-PBDEs) remains poorly elucidated, although LC-MS/MS is essential for their analysis. This study systematically characterizes their fragmentation behavior...
Advanced NMR Characterization and Sensitive Detection of Isoaspartate in Proteins [0.03%]
蛋白质中异天门冬氨酸的先进核磁表征与灵敏检测
Manon Julien,Sophie Zinn-Justin,Francois-Xavier Theillet
Manon Julien
Isoaspartate forms spontaneously from Asn deamidation or Asp isomerization, which can plague protein purification and storage processes. Indeed, it often comes with deleterious consequences, from a loss of function to a gain of toxic proper...
Toward a Comprehensive Raman Analysis of Functional Cells With Structured Optical Traps [0.03%]
具有结构光阱的富集功能性细胞的拉曼综合分析方法研究
Panchanil Sarmah,Vidya Rastapur,Ruchee Khanna et al.
Panchanil Sarmah et al.
Optically trapping RBCs with conventional Gaussian laser beams in physiological media and studying their properties have long been of interest, as it can be beneficial for understanding RBC-related disorders and their manifestations. An eve...
Simultaneous Detection of Dual-Component Gases Using a Single Multipass Photoacoustic Cell with Cross-Patterned Spots [0.03%]
基于交叉光斑的单腔体多程 photoacoustic 电池用于双组分气体的同时检测
Hongchao Qi,Xinyu Zhao,Wen Liu et al.
Hongchao Qi et al.
An innovative photoacoustic (PA) sensor based on a single multipass photoacoustic cell with cross-patterned spots has been developed to achieve simultaneous detection of dual-component gases. The multipass cell (MPC) integrates two fiber co...
A Potassium Phosphoramidate-Based Strategy for Compiling and Profiling the Noncanonical N-Phosphoproteome of Nasopharyngeal Carcinoma [0.03%]
基于钾磷酸酰胺的策略用于编译和剖析鼻咽癌非经典N-磷蛋白质组
Yuqiu Wang,Minchu Tang,Xiaole Song et al.
Yuqiu Wang et al.
Protein N-phosphorylation, especially in eukaryotes, plays a critical role in cell signal transduction and tumorigenesis. However, the N-phosphoproteome has not been extensively profiled due to its low abundance and chemical lability. Herei...
CASMDB: An Open-Source Database of Metabolite Annotation Data for 1D 1H NMR-Based Metabolomics [0.03%]
基于一维氢核磁共振的代谢组学开放式的代谢产物注释数据库（CASMDB）
Morgan W Hayward,Luca G Mureddu,Gary S Thompson et al.
Morgan W Hayward et al.
In metabolomics analyses, databases are invaluable for the identification of individual metabolites in experimentally collected samples. Publicly available databases for NMR-based metabolomics are unfortunately incomplete with respect to ex...
Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes [0.03%]
基于冷凝增殖管和屏幕印刷碳电极上免疫测定的气溶胶化蛋白检测法
Joowon Park,Thaisa A Baldo,Bethany Unruh et al.
Joowon Park et al.
Rapid point-of-need detection of aerosolized pathogens remains a critical need for environmental monitoring and infection control. Traditional filter-based bioaerosol collection methods are time-consuming and nonselective, capturing both in...