AnnoTCM: An Annotation Tool for Multimodal Metabolite-Phenotype Integration in Decoding Bioactive Compounds of Traditional Chinese Medicine [0.03%]
一个用于多模态代谢物表型整合的注释工具 以解析传统中药中的生物活性成分
Xingyi Liang,Yixin Cui,Yanwei Tan et al.
Xingyi Liang et al.
Despite decades of pharmacological interest, the systematic identification of bioactive compounds in natural products (NPs) and traditional Chinese medicines (TCMs) remains constrained by the chemical complexity of herbal formulations and t...
Development of a Sensitive Lateral Flow Immunoassay Using Recombinant Rabbit Single-Chain Variable Fragments Fused to a Nitrocellulose-Binding Protein [0.03%]
基于重组兔单链可变片段免疫层析检测技术的发展
Ngoc Minh Nguyen,Ryosuke Mukai,Makoto Nita et al.
Ngoc Minh Nguyen et al.
Lateral-flow immunoassays (LFIAs) are increasingly used as diagnostic tools for point-of-care testing because of their speed, simplicity, and cost-effectiveness. However, traditional antibody immobilization techniques, which primarily rely ...
Chemigenetic Nanoprobe for Proximity Sensing Dynamics of Lactate Efflux [0.03%]
用于检测乳酸外排动力学的化学遗传型纳米探针
Qin Xu,Xu Zhao,Li-Jian Chen et al.
Qin Xu et al.
Lactate metabolism, a fundamental process in the biological system, plays a crucial role in cell fate decisions and metabolic homeostasis. However, the inherent features of the lactate metabolite, especially its dynamic efflux behavior, pre...
NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm [0.03%]
基于冷冻电子显微镜的图像配准算法的核磁共振谱图对齐方法
Colin A Hemme,Owen A Warmuth,Songlin Wang et al.
Colin A Hemme et al.
With recent advances in magic-angle spinning (MAS) solid-state NMR (SSNMR) resolution, precise spectral alignment has become a critical bottleneck in data processing workflows. While solution NMR employs deuterium lock systems, most SSNMR p...
Portable Sensor for Detecting Trifluoroacetic Acid in Bottled Water: A Visualization Method Based on Multiple Synergistically Induced Aggregation [0.03%]
一种便携式传感器用于检测瓶装水中的三氟乙酸：基于多种协同诱导聚集的可视化方法
Haocheng Yang,Siyu Huang,Jinhong Luo et al.
Haocheng Yang et al.
Per- and polyfluoroalkyl substances (PFAS) are currently some of the most difficult persistent organic pollutants to degrade in the world. In particular, the concentration of ultrashort-chain trifluoroacetic acid (TFA) in all water bodies i...
Ying Bao,Liming Guo,Ziwen Gao et al.
Ying Bao et al.
Bimetallic Valence Modulation Strategy Boosted Peroxidase-/Laccase-like Activity of a MoCu-2MI MOF Nanozyme for Portable-Device-Enabled Trimodal Sensing of D-Penicillamine and Colorimetric Analysis of Phenolic Pollutants [0.03%]
一种用于D-青霉胺现场即时三重检测和酚类污染物比色分析的含MoCu-2MI金属有机框架纳米酶的双金属价态调控策略
Daoqing Fan,Shuai Qin,Chuanping Li et al.
Daoqing Fan et al.
Rational design of high-performance nanozymes with multiple enzyme-mimicking activities for biochemical sensing is one of the most promising directions in this area. D-PA is a kind of S-containing pharmaceutical for treating various disease...
Quantitative Detection of Serum Protein-Specific Glycosylation in Ovarian Cancer Based on a Signal-Convertible Mass-Tagged Probe Set [0.03%]
基于信号转换型质谱标记探针集的卵巢癌血清蛋白特异性糖基化的定量检测
Bo Sun,Yiming Zhao,Yang Li et al.
Bo Sun et al.
The aberrant expression of sialic acid (Sia) on the surface of serum CA125 protein (CA125-Sia) is closely related to the occurrence of ovarian cancer and may have potential utility for early detection of ovrian cancer. However, the accurate...
A Versatile CRISPR/Cas12a Autocatalytic Cascade System via Structure-Switching V-Type Split Probe for Highly Sensitive DNA Diagnostics [0.03%]
基于结构转换的V型探针的Cas12a自动化催化级联反应系统用于高灵敏度DNA检测
Zhun Lin,Zhe Pu,Jiacheng Wu et al.
Zhun Lin et al.
The rapid detection of pathogen nucleic acids is critical for controlling infectious disease outbreaks and providing timely treatment. However, current molecular diagnostic applications, including sensitive CRISPR/Cas-based detection system...
Superhydrophobic MXene Spherical Cavity Arrays as Surface-Enhanced Raman Scattering Sensors for Label-Free Gas Detection and Photothermal Desorption [0.03%]
超疏水MXene球形腔阵列用于无标记气体检测和光热解吸的表面增强拉曼散射传感器
Guangming Zhang,Yang Wu,Wanning Dou et al.
Guangming Zhang et al.
High-performance surface-enhanced Raman scattering (SERS) gas sensing has significant potential in environmental monitoring and public health safeguard. However, label-free gas detection remains a substantial challenge due to the high mobil...