A Workflow-Driven Multisensor Scanning System for In Situ Extensive Hyperspectral Chemical Imaging of Paintings [0.03%]
一种用于绘画原位广泛超光谱化学成像的基于工作流的多传感器扫描系统
Lucilla Pronti,Martina Romani,Antonella Balerna et al.
Lucilla Pronti et al.
This work introduces a novel workflow-driven multisensor scanning system for comprehensive hyperspectral chemical imaging of painted surfaces, employed in situ. Integrating X-ray fluorescence, UV-induced fluorescence, and FT-IR spectroscopy...
Machine Learning-Driven Extracellular Vesicles Peptidomics Powers Precision Classification of Endometrial Cancer [0.03%]
机器学习驱动的细胞外囊泡肽组学助力子宫内膜癌的精准分类
Yunhan Yang,Dandan Li,Pengfei Wu et al.
Yunhan Yang et al.
Endometrial cancer (EC) molecular subtyping is critical for prognosis and treatment but remains hindered by reliance on invasive tissue biopsies and time-consuming genomic sequencing. Here, we present a minimally invasive approach integrati...
Probing Surface Changes in Fe-Ni Oxide Nanocatalysts with a ToF-SIMS-Coupled Electrochemistry Setup and Principal Component Analysis [0.03%]
结合飞行时间二次离子质谱电化学装置和主成分分析探究Fe-Ni氧化物纳米催化剂的表面变化
Heydar Habibimarkani,Jörg Radnik,Vasile-Dan Hodoroaba et al.
Heydar Habibimarkani et al.
Understanding catalyst surface dynamics under operating conditions is essential for improving electrocatalytic performance. Here, we present a novel approach combining electrochemical treatment with contamination-free transfer to Time-of-Fl...
Dual Comb Spectrometer for the Determination of Stable Isotopic Ratios of Atmospheric CO2 with Sub-Permille Precision at Atmospheric Pressure [0.03%]
一种可在大气压下进行CO2稳定同位素亚千分偏差测定的双光梳光谱仪
Jens Goldschmidt,Nicolas Brugger,Leonard Nitzsche et al.
Jens Goldschmidt et al.
We present a mid-infrared dual comb spectrometer for the precise determination of the isotopic ratio of the stable CO2 isotoplogues 12C16O2 and 13C16O2 under atmospheric pressure. The spectrometer is based on electro-optic intensity modulat...
Enhanced Integrative Diagnosis and Therapeutic Strategy for Hepatic Ischemia-Reperfusion Injury through HOCl-Sensitive Cysteine Delivery System for Targeted Antioxidant Modulation [0.03%]
一种HOCl敏感型半胱氨酸传递系统用于肝缺血再灌注损伤的整合诊断和治疗策略
Wen Zhang,Yanjiao Li,Dongni Yin et al.
Wen Zhang et al.
Hepatic ischemia-reperfusion injury (HIRI) is a major cause of postoperative liver insufficiency and liver failure, and its pathological process is closely related to the synergistic dysregulation of oxidative stress. Currently, the diagnos...
Spatiotemporal Analysis of Enzyme Activity in Lung Cancer Tissue via Deuterated Probe-Based Mass Spectrometry-Fluorescence Dual-Modal Imaging [0.03%]
基于氘标记示踪剂的质谱成像和荧光成像双重模态分析肺癌组织中蛋白酶活性的时空分布规律
Yanmei Yang,Yuling Zhong,Zhao Wang et al.
Yanmei Yang et al.
As an important class of biomarkers, enzyme activity has been implicated in various diseases, making it of great importance for disease diagnosis and therapy. Thus, accurately mapping the enzyme activity in disease tissue is essential. Neut...
Bottom-Up Protein Analysis Workflow for Simultaneous Characterization of Payloads, Disulfide Bonds, and Free Thiols in Antibody-Drug Conjugates [0.03%]
一种自下而上的蛋白质分析工作流程 可同时表征抗体偶联药物的连接物、二硫键和游离巯基
Keting Zhou,Yu Xia
Keting Zhou
Antibody-drug conjugates (ADCs) are biopharmaceutical agents comprising cytotoxic payloads covalently linked to monoclonal antibodies via chemical linkers. Their structural heterogeneity presents analytical challenges for therapeutic develo...
Quantum Dots-Enhanced Laser-Induced Breakdown Spectroscopy for Ultrasensitive Quantification of Trace Metals in Oils [0.03%]
基于量子点增强激光诱导击穿光谱法的油中痕量金属超灵敏定量分析研究
Wanying Ding,Shilong Xu,Youlong Chen et al.
Wanying Ding et al.
We developed a novel quantum dots-enhanced laser-induced breakdown spectroscopy (QDE-LIBS) technique for the ultrasensitive detection of trace metals in lubricating oils. By utilizing AgNC@AgAux core-shell quantum dots (QDs) as signal ampli...
Ionophore-Based SERS Nanosensors for Selective Electrolyte Detection and Intracellular Mapping [0.03%]
用于选择性电解质检测和细胞内分布映射的离子载体型表面增强拉曼纳米传感器
Laiqi Zhang,Zhiyu Tang,Alejandra Coronel-Zegarra et al.
Laiqi Zhang et al.
Quantitative detection of electrolyte ions in complex biological environments requires nanosensors with high sensitivity, reproducibility, and selectivity. We report an ionophore-based nanoscale surface-enhanced Raman spectroscopy (SERS) pl...
In Situ, Time-Resolved Measurements of Lithium-Ion Battery Gases During Cell Formation Using Mid-IR Laser Absorption Spectroscopy [0.03%]
基于中红外激光吸收光谱的锂离子电池化成过程原位气体组分时间分辨检测方法研究
Raghav G Poddar,Joshua Stiborek,Nathan J Kempema et al.
Raghav G Poddar et al.
Real-time non-extractive measurements of gaseous byproducts are needed to understand the buried interfacial formation chemistry of lithium-ion batteries at various scales; however, conventional gas sensors (e.g., those based on mass spectro...