A Real-Time Enzyme-Linked Aptamer Assay (RT-eELAA) for Rapid and Sensitive Detection of Viral Antigens in Saliva Using Electrochemical Readout [0.03%]
基于电化学生物传感器的实时适配子酶联反应(RT-eELAA)快速灵敏检测 saliva 中病毒抗原
Bal Ram Adhikari,Qing Wang,Jiuxing Li et al.
Bal Ram Adhikari et al.
Despite the need for reliable rapid antigen tests for infectious disease diagnostics, tests that combine rapid answer-to-result times with high sensitivity and specificity remain elusive. A major challenge in developing such tests is the lo...
Improving Regions of Interest Multivariate Curve Resolution: Development of an Empirical Metric System through the Study of Passive Sampling Extracts of Wastewater in Antarctica [0.03%]
通过研究南极废水被动采样萃取物改进区域兴趣多元曲线解析：通过研究南极废水被动采样萃取物发展经验度量系统
Barbara Benedetti,Carlos Perez-Lopez,Henry MacKeown et al.
Barbara Benedetti et al.
The huge potential of liquid chromatography-high-resolution mass spectrometry (LC-HRMS) still comes along with the challenges of data analysis. Regions of interest multivariate curve resolution (ROIMCR) is a valid chemometric tool when work...
Localized Surface Plasmon Resonance-Mediated Fabry-Pérot Interferometer for Enzyme-Free Glucose Detection [0.03%]
一种用于无酶葡萄糖检测的局域表面等离激元共振介导法布里-珀罗干涉仪
Hairihan Zhou,Yue Zhang,Yueyang Zhang et al.
Hairihan Zhou et al.
The well-known Fabry-Pérot (F-P) cavity serves as a crucial element of complex optical devices, offering distinctive functionalities. However, modifying reflection properties by altering the underlying optical structure remains challenging...
Accurate Diagnosis of Colorectal Cancer Using a Combination of Lectin-Induced Recombinase Polymerase Amplification and CRISPR/Cas12a Assay on a Point-of-Care Testing Platform with Deep Learning Assistant [0.03%]
基于深度学习的结直肠癌体外快速诊断新技术研究与应用原型开发
Xudong Sun,Xiaotong Li,Hao Jiang et al.
Xudong Sun et al.
Specific glycosylation patterns on exosome surfaces represent novel diagnostic biomarkers for cancer liquid biopsy. Lectins can induce exosome aggregation through multiple bindings with exosomal glycoproteins. In this work, we developed a o...
In Situ Quantification of Ammonia in Biofluids using High-Resolution Nuclear Magnetic Resonance [0.03%]
高分辨率核磁共振在体量化生化介质中的氨量
Li-Hua Xu,Ya-Ting Chen,Xing Zhang et al.
Li-Hua Xu et al.
Ammonia is an important metabolite and is involved in many physiological processes; the abnormal level of ammonia in vivo is correlated with the different phenotypes of diseases. Quantification of ammonia is important for disease diagnosis....
Palina Ryzhaya,Pavlína Pírek,Zbyněk Zdráhal et al.
Palina Ryzhaya et al.
Arginine-specific cleavage is the primary method used to prepare lysine-rich histone proteins in bottom-up proteomics. As the Arg-C enzyme has demonstrated suboptimal specificity, cleavage at the carboxyl side of arginine residues is typica...
On Selecting Robust Approaches for Learning Predictive Biomarkers in Metabolomics Data Sets [0.03%]
代谢组学数据集中学习预测生物标志物的鲁棒方法的选择
Thibaud Godon,Pier-Luc Plante,Jacques Corbeil et al.
Thibaud Godon et al.
Metabolomics, the study of small molecules within biological systems, offers insights into metabolic processes and, consequently, holds great promise for advancing health outcomes. Biomarker discovery in metabolomics represents a significan...
Z-Scheme Bismuth-Based Ternary Heterostructured Photoelectrochemical Sensor Integrated with Cu3P Nanoparticles as a Multifunctional Signal Probe for Quantifying Circulating Tumor Cells [0.03%]
集成了Cu3P纳米粒子作为多功能信号探针的Z方案铋基三元异质结光电化学传感器用于量化循环肿瘤细胞
Chengqi Bao,Rong Shao,Yan Lu et al.
Chengqi Bao et al.
Circulating tumor cells (CTCs) are widely acknowledged as critical biomarkers for early cancer diagnosis and prognosis, highlighting the urgent need for the development of sensitive and accurate detection methods for CTCs. Herein, a photoel...
Super-Resolution FLIM Imaging of Intracellular Lipid Microenvironments with a Dual-Responsive Polarity- and pH-Sensitive Fluorescent Probe [0.03%]
一种新型荧光探针用于超分辨FALCON成像映射细胞内脂滴微环境极性和酸碱度分布状况
Shixian Cao,Caixia Sun,Wendong Jin et al.
Shixian Cao et al.
The microenvironment is essential for the proper function of organelles and biological systems. In particular, its physical properties─such as polarity and pH profoundly influence both physiological and pathological processes. Therefore, d...
A Comprehensive and Ultrasensitive Isotope Calibration Method for Soil Amino Compounds Using Orbitrap Mass Spectrometry [0.03%]
基于轨道离子阱质谱的土壤氨基酸化合物同位素定年方法及灵敏度改善
Tao Li,Yuhua Li,Erika Salas et al.
Tao Li et al.
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (∼40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their ...