Dual-Target Fluorescent Imaging of Hg2+ and Cell Membrane Stress in Live Plants [0.03%]
活体植物中Hg2+和细胞膜压力的双重靶标荧光 imaging
Yan Huang,Bo Zhang,Min Yin et al.
Yan Huang et al.
Monitoring mercury ion (Hg2+) accumulation and its phytotoxicity in plants requires analytical methods that provide both spatial and functional information beyond simple destructive quantification. We report HBTD-Hg, a dual-target fluoresce...
Amplified Assembly of a Multifunctional 3D DNA Nanomachine for Electrochemical and Colorimetric Dual-Mode Assays [0.03%]
用于电化学和比色双模式检测的多功能三维DNA纳米机器的放大组装
Guopei Fang,Yingxue Liu,Wan Huang et al.
Guopei Fang et al.
DNA nanomachines have been widely applied in biosensing; however, further enhancing their signal amplification capability and assay reliability remains a major challenge. Herein, a novel strategy was proposed to construct a multifunctional ...
Node-Activated Persulfate Reduction in a Terbium Metal-Organic Framework for Low-Potential Electrochemiluminescence and Hydroquinone Sensing [0.03%]
铽金属有机骨架活化过硫酸盐在低电位下产生鲁米诺电化学发光及对羟基苯胲传感中的应用
Qiaoting Yang,Junhao Deng,Taoran Wu et al.
Qiaoting Yang et al.
Persulfate (S2O82-)-based electrochemiluminescence (ECL) typically requires high cathodic potentials to activate S2O82- and often suffers from inefficient utilization of short-lived radical intermediates. Here, we report a terbium metal-org...
Isomerization Transmission to G-Quadruplex (IT2G4) for Discriminating Natural Isoquinoline Alkaloid Isomers [0.03%]
用于识别异喹啉生物碱立体异构体的同分异构体传输至G-四链体（IT2G4）的方法
Sihui Huang,Jiahuan Zhou,Qiyao Chen et al.
Sihui Huang et al.
Exploring efficient strategies to discriminate bioactive natural isomers using nucleic acids is of great importance to advanced biosensing platform development and pharmaceutical discovery. The DNA duplex-based strategy gets trouble in disc...
METLIN 960 K: An Empirical Tandem Mass Spectrometry Data Resource [0.03%]
METLIN 960 K：一个经验性的串联质谱数据资源
Winnie Uritboonthai,Aries E Aisporna,Linh Hoang et al.
Winnie Uritboonthai et al.
METLIN 960 K represents the largest collection of experimentally acquired small-molecule MS/MS spectra currently available. We introduce a reengineered publicaly accessible METLIN platform integrating high-resolution tandem mass spectrometr...
Discovery of Nanobodies against Tetramethylenedisulfotetramine by Integrating Next-Generation Sequencing and Moderate Random Mutagenesis [0.03%]
结合新一代测序和中等随机诱变的四甲基联苯二硫化物纳特体发现技术
Chenxi Gao,Liuchuan Guo,Huijuan Yang et al.
Chenxi Gao et al.
Tetramethylenedisulfotetramine (TETS) is a highly neurotoxic rodenticide and a potential terror agent to national security that can cause death within hours. Therefore, antibody-based guidance for timely determination and treatment is urgen...
Donor-Acceptor Engineering in Covalent Organic Frameworks Enabling Dual Fluorescence and Nanozyme Activity for On-Site Antibiotic Detection [0.03%]
用于现场抗生素检测的给体-受体工程共价有机框架使双荧光和纳米酶活性成为可能
Shuaijie Zhang,Alituniguli Maimaiti,Yin-Sheng Liu et al.
Shuaijie Zhang et al.
The integration of distinct functionalities into single covalent organic frameworks (COFs) is highly desirable for advanced sensing, yet remains synthetically challenging. Herein, we address this by designing and synthesizing donor-acceptor...
A Universal Framework for Blood Ionome Extraction and Intelligent Quality Control in 1H NMR Metabolomics [0.03%]
一种通用的血液离子组提取和智能质量控制框架用于¹H核磁代谢组学研究
Anastasios Theodorou,Ivan Vučković,Eirini Papadimitriou et al.
Anastasios Theodorou et al.
Nuclear magnetic resonance (NMR) spectroscopy is a cornerstone of metabolomics and clinical bioanalysis; yet, its routine clinical adoption is limited by challenges in quality control (QC) and spectral interpretation. In blood-based NMR stu...
Single-Atom Fe/Au Nanozymic Electrode to Accelerate Glucose Oxidation for Self-Powered Sensing [0.03%]
单原子Fe/Au纳米酶电极用于加速葡萄糖氧化以实现自驱动传感
Linyun Zhang,Jiaying Bei,Xun Li et al.
Linyun Zhang et al.
Self-powered sensing based on enzymatic biofuel cells (EBFCs) provides a promising platform for miniaturized and portable exosome analysis by converting biochemical reactions directly into electrical output. However, the operational reliabi...
Simultaneous Visualization of Glutathione and Hydrogen Peroxide with a Dual-Responsive Fluorescent Probe to Elucidate Redox Homeostasis in Alzheimer's Disease Models [0.03%]
用于同时可视化谷胱甘肽和过氧化氢的双响应型荧光探针以阐释阿尔茨海默病模型中的红氧平衡机制
Haoyu Jin,Zhaomin Xu,Han Tang et al.
Haoyu Jin et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which oxidative stress plays a critical role in pathogenesis. As key reactive species governing oxidative stress, the dynamic interplay between glutathione (GSH) and hy...