A pH-Gated Fluorescent Probe for Visualizing Hypochlorous Acid: From Pyroptosis to Tumor Imaging [0.03%]
一种用于可视化次氯酸的pH门控型荧光探针：从细胞焦亡到肿瘤成像
Yixuan Zhu,Caiyun Liu,Xiaodi Rong et al.
Yixuan Zhu et al.
Precise visualization of hypochlorous acid (HOCl) in vivo is limited by tissue autofluorescence and nonspecific activation. Addressing these limitations requires dual-locked logic-driven molecular tools that integrate near-infrared (NIR) em...
Highly Specific Detection of Sc3+ in Rare Earth Elements Using a DNA-Functionalized, Silica Nanowire-Filled Micropipette [0.03%]
一种基于DNA功能化硅纳米线的微管技术实现稀土元素中微量Sc3+的高灵敏度检测
Yanhua Rao,Zhongyu Yang,Yongteng Long et al.
Yanhua Rao et al.
Scandium (Sc), as a critical rare earth element (REE), holds significant application value in advanced manufacturing, energy materials, catalysis, and other fields. However, due to the common coexistence of Sc with light and heavy REEs, whi...
Multichannel Integrated Fiber-Optic End-Face Sensor for Deuterium Detection from Hydrogen Via Flow-Temperature Synergistic Regulation [0.03%]
基于流温协同调控的氘从氢中多通道集成光纤端面传感器检测
Feng Zhang,Lingxin Kong,Wenyu Yan et al.
Feng Zhang et al.
Inspired by the selective adsorption and separation technology of isotope gases using porous materials, this work reports the first successful realization of optical fiber-based deuterium (D2) sensing in the presence of hydrogen (H2). Initi...
Native Multidimensional Protein Complex Identification and Topology Characterization (Native MudPIT) [0.03%]
天然多维蛋白质复合物鉴定及拓扑结构表征（Native MudPIT）
Zihao Qi,Fei Fang,William J Moeller et al.
Zihao Qi et al.
The initiation and progression of diseases are usually due to biological processes going awry, driven by proteins in complexes that often assemble via noncovalent interactions of monomeric or multimeric subunits. A broader view of protein c...
"Midas Touch": Revealing the Collaborative Mechanism of Nanoconfined Aggregation-Induced Luminescence and Antibody Recognition for AI-Assisted Pathogen Immunochromatographic Detection [0.03%]
“点金术”：纳米限域聚集诱导发光与抗体识别协同机制揭示用于人工智能辅助病原体免疫层析检测
Zhaowen Cui,Jiayi Guo,Yuechun Li et al.
Zhaowen Cui et al.
Foodborne pathogen contamination poses a persistent and severe threat to global public health and safety, creating an urgent need for rapid, sensitive, and user-friendly on-site detection technologies. Herein, we report a synergistic strate...
CSU-EP: Contrastive Learning for Unifying Experimental and Predicted EI-MS Spectra [0.03%]
CSU-EP：用于统一实验和预测的EI-MS光谱的对比学习
Ting Xie,Yaoyu Zhuang,Jiongyu Wang et al.
Ting Xie et al.
Spectral library matching is the most common method for compound identification in mass spectrometry (MS), but it is limited by the coverage of experimental libraries. In-silico libraries can expand the searchable chemical space, yet their ...
Cell-Type-Specific Mechanical Thresholds of Piezo1 Regulate Cancer Cell Migration and Proliferation [0.03%]
Piezo1的细胞类型特异性机械阈值调节癌细胞迁移和增殖
Jiawei Duan,Jinrui Zhang,Tianyi Zou et al.
Jiawei Duan et al.
Piezo1 exhibits paradoxical roles in different malignancies, promoting metastasis in some contexts while suppressing tumor progression in others. This functional dichotomy significantly hampers its potential as a therapeutic target. To unco...
Photoacoustic Probe for Rapidly Recognizing Superoxide Anion Affording Visualized Tracing of Ferroptosis-Mediated Acute Liver Injury [0.03%]
一种快速识别超氧阴离子的 photoacoustic 探针用于可视化追踪铁死亡介导的急性肝损伤
Yidong Bin,Lixian Huang,Caiying Li et al.
Yidong Bin et al.
As an emerging form of regulated cell death, ferroptosis has been identified as a key contributor to the pathogenesis of several diseases. Superoxide anion (O2•-), a key reactive oxygen species, is closely associated with ferroptosis-media...
ClipMol: A Molecular Representation Learning Framework for CCS Prediction via SMILES-InChI Dual-View Chemical Language Alignment [0.03%]
基于SMILES和InChI的双语化学语言对齐的CCS预测分子表示学习框架ClipMol
Shengcai Shen,Chaoting Shi,Yu Wang et al.
Shengcai Shen et al.
Although existing molecular pretraining models have achieved favorable performance on various downstream tasks, their reliance on explicit three-dimensional conformer sampling or external natural-language corpora often increases computation...
Biomarker-Triggered Fluorogenic Label in Live Systems via Switchable Iminosydnone-Alkyne Cycloaddition [0.03%]
基于可切换亚胺茋炔环加成反应的活体系统生物标志物触发荧光探针
Bingfeng Dai,Qin Zhou,Zhengkun Zhang et al.
Bingfeng Dai et al.
Precise spatiotemporal control over bioorthogonal labeling is crucial for studying biological processes in living systems. While external triggers like light offer control, methods responsive to intrinsic cellular stimuli remain scarce. Her...