Hollow Dodecahedral Nanocages for Reliable Multi-Level Differentiation of Urological Cancers through Non-Invasive Metabolic Fingerprinting [0.03%]
中空十二面体纳米笼通过非侵入性代谢指纹鉴定泌尿系统癌症的多级分化
Ting Zhang,Heyuhan Zhang,Jia Qi et al.
Ting Zhang et al.
Urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), represent the most common malignancies of the urinary system and account for a significant proportion of global cancer-related morbidity and ...
Tile-Based Fisher Ratio Analysis with Support Vector Machine Regression Modeling of GC×GC-TOFMS Data of VOCs Produced by Malassezia pachydermatis Grown at Variable pHs [0.03%]
基于支持向量机回归模型的GC×GC-TOFMS数据的瓦片基Fisher比分析以及由不同pH值下生长的马尔萨扎菌孢子致病型产生的VOCs数据分析
Lina Mikaliunaite,Jamison M Whitten,Jodie C Tokihiro et al.
Lina Mikaliunaite et al.
Malassezia yeasts are commensal microorganisms found in human and animal skin. Species of Malassezia have been connected to skin and opportunistic infections, where certain microenvironmental conditions are required in the host for the path...
Enhanced Fingerprinting Strategy for Rapid and Accurate Quantitative Source and Contaminant Apportionment via Online SPE-UHPLC-QTOF-MS [0.03%]
基于在线固相萃取-超高压液相色谱-高分辨质谱的快速精准定量化合物来源及污染溯源方法学研究
Di Xia,Shuna Fu,Ping Yang et al.
Di Xia et al.
This study refined the nontarget fingerprinting approach for accurate source apportionment by combining online solid-phase extraction with liquid chromatography-quadrupole time-of-flight mass spectrometry in data-independent acquisition mod...
SERS-Active Superhydrophobic Sponge for One-Step Enrichment and Ultrasensitive Quantification of Phthalate Esters in Bottled Water [0.03%]
用于瓶装水中酞酸酯一步法浓缩和超灵敏定量的表面增强拉曼光谱活性超强疏水海绵
Shengmao Chao,Xueqing Wang,Fan Li et al.
Shengmao Chao et al.
Phthalate esters (PAEs), prevalent plasticizers used extensively in packaging materials, pose significant environmental and health risks. Addressing the challenge of their trace detection, we introduce a dual-functional superhydrophobic spo...
Signal Perception in Two-Dimensional Mapping Techniques: Just Noticeable Difference as a Visual Limit of Detection [0.03%]
二维映射技术中的信号感知：可察觉差异作为视觉检测极限
Filip Cernatič,Lukas Brunnbauer,Kristina Mervič et al.
Filip Cernatič et al.
The limit of detection (LOD) is a ubiquitous figure of merit for characterizing the performance of instrumental methods in analytical chemistry, with the well-known formula "three times the standard deviation of the blank" serving as a comm...
A Low-Background, High-Flatness Mounting Method for In Situ SIMS Isotopic Analysis for Fine-Grained Samples [0.03%]
适用于细粒样品原位同位素分析的低背景高平坦度装样方法
Yu-Bing Gao,Jia-Long Hao,Zhan Zhou et al.
Yu-Bing Gao et al.
Accurate in situ determination of water content and hydrogen isotopes in minerals is essential for understanding magmatic processes on Earth and other planetary bodies. However, such measurements are technically challenging due to low hydro...
Early Detection of Multiple Sclerosis Using Spectroscopic Epstein-Barr Virus Biosensors Based on Infection Mechanism Mimicry [0.03%]
基于感染机制模拟的光谱型EB病毒生物传感器的早期检测多发性硬化症研究
Ülkü Anık,Nil Su Çaylayık
Ülkü Anık
The association between Epstein-Barr virus (EBV) and multiple sclerosis has made the asymptomatic detection of EBV very significant. In this study, a spectroscopic/colorimetric EBV biosensor was developed for practical and early screening b...
CaMK2rep: A Highly Sensitive Genetically Encoded Biosensor for Monitoring CaMKII Activity in Mammalian Cells [0.03%]
一种在哺乳动物细胞中用于监测钙/Calmodulin依赖性蛋白激酶II活性的高灵敏度遗传编码生物传感器
Elena Martínez-Blanco,Raquel de Andrés,Lucía Baratas-Álvarez et al.
Elena Martínez-Blanco et al.
Accurately monitoring calcium/calmodulin-dependent protein kinase II (CaMKII) activity in cells remains a significant challenge due to the limited sensitivity and narrow dynamic range of existing genetically encoded sensors. Here, we introd...
Point-of-Care Meat Freshness Evaluation: Myoglobin-Involved Redox Reaction Analysis via Smartphone Imaging [0.03%]
基于智能手机成像的便携式肉类新鲜度评价：肌红蛋白氧化还原反应分析
Hui Zhu,Yue Jiang,Yu-Ping Wei et al.
Hui Zhu et al.
Meat freshness is essential for ensuring food safety and protecting consumer health. However, substantial resource waste often occurs when consumers rely on their senses to assess meat. Herein, we developed a smartphone-based platform utili...
Deciphering the Mechanism of Interactions between Polyubiquitin Chains and Caspase Activation and Recruitment Domains Using Protein-Polymer-Engineering-Assisted Native Mass Spectrometry [0.03%]
基于蛋白质聚合工程的原位质谱解析泛素链与半胱天冬酶募集结构域之间相互作用的机制
Bin Song,Qingrong Chen,Rongrong Dai et al.
Bin Song et al.
Polyubiquitin (polyUb) chain topology plays important roles in determining Ub chain conformation and therefore directs specific cellular signal transductions. However, little is known about the conformational dynamics of polyUb chains and t...