Reliable Quantification of Conjugated Peptides from T-DM1 In Vivo by Two-Step Enrichment and Internal Standards from Derivatized Analytes [0.03%]
基于 derivatization 内标及两步富集法的 T-DM1 联结肽绝对定量研究
Meiling Qi,Ying Xiong,Meiling Chen et al.
Meiling Qi et al.
Antibody-drug conjugates (ADCs) are the conjugation of antibody with cytotoxic payloads. Conjugated peptides that originate from ADCs are commonly used for pharmacokinetics (PK) study. However, a reliable and sensitive method for the quanti...
Supramolecular Fluorescence Probe for Rapid Visual Detection of Pyrethroid and Composite Aerogel as a Pyrethroid Vapor Sensor [0.03%]
超分子荧光探针快速视觉检测拟除虫菊酯及复合气凝胶拟除虫菊酯蒸汽传感器
Anqi Liu,Qipeng Zhang,Lei Pan et al.
Anqi Liu et al.
The threat of environmental and health damage using pyrethroid long-term has been of particular concern. Limited by complex current methods and limited quantification capability, achieving efficient and fast detection for pyrethroid is stil...
Accurate and Sensitive Detection of Pathogenic Bacteria Living in Wastewater via Aptamer-Loaded GFET for Sewage Treatment Analysis [0.03%]
基于适配体的GFET传感器检测废水中的病原菌
Sung Eun Seo,Kyung Ho Kim,Jun-Seob Kim et al.
Sung Eun Seo et al.
A highly accurate and sensitive monitoring platform for wastewater is needed for the detection of wastewater borne pathogens. For the fabrication of an environmental monitoring platform, an aptamer-integrated graphene field-effect transisto...
Enabling SARS-CoV-2 Wastewater Surveillance Using an Integrated Microfluidic Chip [0.03%]
使用集成微流体芯片启用SARS-CoV-2废水监测
Mohammad Dehghan Banadaki,Soroosh Torabi,William D Strike et al.
Mohammad Dehghan Banadaki et al.
Wastewater-based epidemiology (WBE) has emerged as a critical public health tool, offering cost-effective and noninvasive surveillance of infectious diseases through wastewater testing. Despite its potential, WBE implementation in low-resou...
Application of Non-G-Quadruplex Hemin Aptamers to Hemin Detection and Heme Oxygenase 1 Activity Evaluation via Spatial Conformational Constraint [0.03%]
基于空间构象约束的血红素检测及诱导的HO-1活性评价传感平台
Changjiang Li,Jiani Wu,Xiaolong Li et al.
Changjiang Li et al.
The correct spatial folding of the aptamer significantly influences its binding performance with the target. By extending the terminal double-stranded domain of the hemin aptamer, we obtained apt71 with a more stable spatial conformation. T...
Katelyn Downey,Kiera Ronda,Peter M Costa et al.
Katelyn Downey et al.
NMR spectroscopy is a critical tool for environmental and biological research, but the physical and financial barriers of standard "high-field" NMR spectrometers can limit applications, especially in the environmental sciences. Low-field be...
Photoactive Covalent Organic Framework-Modulated Zinc-Air Battery Self-Powered Biosensor for Detecting Hemagglutinin Protein of H1N1 Influenza Virus [0.03%]
用于检测H1N1流感病毒血凝素蛋白的光活性共价有机框架调制锌空气电池生物传感器
Qian Cui,Zhen Wu,Yunxia Jin et al.
Qian Cui et al.
Self-powered electrochemical sensor based on a zinc-air battery has gained wide attention for its good stability and high energy density, making it a promising platform for disease markers detection. However, the large overpotential of the ...
Self-Powered and Sensitive Assay of Caspase-3 Activity Based on an Ultralarge Photocathodic Current Amplified by Polydopamine Modification and a CdIn2S4/CdS Heterojunction Photoanode [0.03%]
基于聚多巴胺修饰和CdIn2S4/CdS异质结光电阳极的超大光电子放大 caspase-3活性自供电灵敏测定法
Guizhen Luo,Zhengyu Zhang,Yuyang Sun et al.
Guizhen Luo et al.
Photocathodic analysis has an excellent anti-interference property but suffers from a weak response signal, restricting its sensitivity and applicability in trace-level assays. Here, a 55-fold amplification of the photocathodic response sig...
Sensitivity-Enhanced Pure Shift Spectroscopy Empowered by Deep Learning and PSYCHE [0.03%]
基于深度学习和PSYCHE的灵敏度增强型纯位移光谱学
Xiaoxu Zheng,Wen Zhu,Xiaoqi Shi et al.
Xiaoxu Zheng et al.
Proton nuclear magnetic resonance (NMR) is the most used NMR technique. However, the limited range of chemical shifts and the complicated multiplet splitting often lead to severe spectral overlapping, making spectral analysis complex. Pure ...
Single-Molecule Imaging for Unraveling the Functional Diversity of 10-23 DNAzymes [0.03%]
单分子成像揭示10-23核酶的功能多样性
Aida Montserrat Pagès,Mirjam Kümmerlin,Rebecca Andrews et al.
Aida Montserrat Pagès et al.
DNA-based enzymes, also known as DNAzymes, have opened new opportunities for signal generation and amplification in several fields including biosensing. However, biosensor performance can be hampered by heterogeneity in the catalytic activi...