Localized Dual-Cycle Amplification Integrating Entropy-Driven Reaction and Catalytic Hairpin Assembly for miRNA Imaging in Living Cells and Tissues [0.03%]
基于熵驱动反应和催化发夹组装的局部双重循环放大用于活细胞和组织中microRNA成像
Liuting Mo,Shiya Tang,Runhong Qin et al.
Liuting Mo et al.
Intracellular microRNA (miRNA) detection plays a crucial role in cancer diagnosis and treatment monitoring. However, current methods face challenges in sensitivity, specificity, and cellular application. Here, we present a novel localized d...
Recombinant Phage Tail Fiber Protein Gp47 Enables Broad-Spectrum Fluorescent Detection of Pseudomonas aeruginosa Strains [0.03%]
铜绿假单胞菌荧光检测用重组噬菌体展示蛋白gp47及其应用
Honglin Yang,Qinchen Liao,Kuixun Chen et al.
Honglin Yang et al.
Pseudomonas aeruginosa (P. aeruginosa) has long been one of the leading opportunistic pathogens responsible for serious healthcare-associated infective diseases. Development of rapid and accurate detection techniques for this pathogen is hi...
Digital Counting of Quantum Dots Nanobeads on Lateral Flow Test Strips Enables Ultrasensitive Point-of-Care Diagnostics [0.03%]
数字化计数量子点纳米珠实现 lateral flow试纸上的超灵敏现场诊断
Wannian Yan,Wenwen Xia,Qinglei Hu et al.
Wannian Yan et al.
Lateral flow assay (LFA) is a versatile platform for the rapid detection of various pathogens, pollutants, and toxins at point of care (POC). However, a traditional lateral flow assay strip is still not sensitive enough for early detection ...
Tracing SO2 Heterogeneous Oxidation Dual-Pathway via Hydrogen-Bond-Enriched Interfacial Radical Chemiluminescence [0.03%]
基于氢键富集界面自由基化学发光的SO₂异相氧化双路径追踪方法研究
Yuxian Zhou,Hongjie Song,Chudong Wei et al.
Yuxian Zhou et al.
Elucidating the SO2 heterogeneous oxidation mechanism at the gas-liquid interface is critical for understanding haze formation. However, the dominant pathways and the oxidant's relative contributions remain ambiguous. This study developed a...
Ultrasensitive, Rapid, and Incubation-Free Surface-Enhanced Raman Scattering Detection of Sulfasalazine with a GF@PDDA-Ag/rGO Functionalized Membrane and Machine Learning [0.03%]
基于GF@PDDA-Ag/rGO功能化膜的无孵育表面增强拉曼散射检测磺胺吡唑的超灵敏与快速检测及机器学习
Meichun Liu,Xinna Yu,Tianshuo Lan et al.
Meichun Liu et al.
Developing rapid detection methods with high sensitivity and real-time capabilities is a critical challenge for monitoring antibiotic pollution. This study presents a flexible surface-enhanced Raman scattering (SERS) sensing substrate (GF@P...
Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform [0.03%]
基于信号关闭的电化学平台在药物递送系统中对miRNA多重检测与定量研究
Wanda Cimmino,Alessia Angelillo,Panagiota M Kalligosfyri et al.
Wanda Cimmino et al.
Lipid nanoparticles (LNPs) are widely used for the delivery of therapeutic microRNAs (miRNAs), especially in coformulated systems where multiple targets are combined to enhance therapeutic efficacy. However, the simultaneous quantification ...
Extrinsic Antifouling Sulfur Quantum Dots: Mechanistic Insights and Their Application in Tyrosinase Detection [0.03%]
外源性抗附着硫量子点：机制见解及其在酪氨酸酶检测中的应用
Zhongnan Huang,Shanbiao Zhang,Yukun Xu et al.
Zhongnan Huang et al.
Sulfur quantum dots (SQDs), as an emerging member of the fluorescent quantum dot family, hold great promise for application in biological analysis and environmental health. However, their intrinsic resistance to fouling in complex matrix po...
Single-Molecule Dual-Channel NIR Fluorescence Probe for Simultaneous Monitoring ATP and ONOO- during Ferroptosis and Hepatic Ischemia-Reperfusion Injury [0.03%]
用于铁死亡和肝脏缺血再灌注损伤过程中同时监测ATP和ONOO-的单分子双通道近红外荧光探针
Wenxuan Zhang,Dechun Li,Yushuang Pu et al.
Wenxuan Zhang et al.
Hepatic ischemia-reperfusion injury (HIRI) is a common and severe complication following liver transplantation and resection. Its core pathological mechanisms involve oxidative stress and disrupted energy metabolism, with ATP depletion and ...
Engineering an Activatable Near-Infrared Fluorogenic Probe for Hypochlorous Acid in Keloid Diagnosis and Therapeutic Evaluation [0.03%]
工程化激活型近红外荧光探针用于表皮样汗管瘤的诊断和疗效评估中的HOCl检测
Lei Li,Haoxinai Wang,Xiaoxue Zheng et al.
Lei Li et al.
Keloid is a skin fibrosis disease characterized by continuous deposition of extracellular matrix and invasive expansion of the lesion. Hypochlorous acid (HOCl), an important member of the reactive oxygen family, has been proven to participa...
A Robust OB-QEPAS Sensor for In-Situ Detection of Dissolved Methane in Natural Waters [0.03%]
一种用于自然水体中甲烷原位检测的稳健型OB-QEPAS传感器
Yingchao Xie,Yuqing Li,Shiling Feng et al.
Yingchao Xie et al.
Accurate monitoring of dissolved methane (CH4) is essential for understanding greenhouse gas dynamics in aquatic ecosystems. Achieving in-field detection that meets the stringent requirements for high sensitivity, strong anti-interference c...