High-Throughput Screening of Amyloid Inhibitors via Covalent-Labeling Mass Spectrometry [0.03%]
基于共价标记的高通量淀粉样蛋白抑制剂筛选及质谱鉴定
Kanitin Khamnong,Vanessa L Stahl,Olivia N Izikson et al.
Kanitin Khamnong et al.
Amyloid fibril formation by proteins is implicated in numerous human diseases, yet few treatments exist in part due to the lack of robust screening methods for amyloid inhibitors. Here, we demonstrate a novel mass spectrometry (MS) assay fo...
Efficient Stereochemical Analysis of Hydroxy Fatty Acids Using PGME and PAME Derivatization [0.03%]
用于羟基脂肪酸立体化学分析的PGME和PAME衍生化方法研究
Soohyun Um,Jaeyoun Lee,Seung Hyun Kim
Soohyun Um
We present a time-efficient and cost-effective approach for the stereochemical analysis of α- and β-hydroxy fatty acids (α-HFAs and β-HFAs) using chiral derivatizing agents, phenylglycine methyl ester (PGME) and phenylalanine methyl est...
Beyond the Nucleus: Cytoplasmic Dominance in Follicular Thyroid Carcinoma Detection Using Single-Cell Raman Imaging across Multiple Devices [0.03%]
超越细胞核：利用单细胞拉曼成像技术跨多设备检测滤泡型甲状腺癌的胞质主导性
Aurelien Pelissier,Kosuke Hashimoto,Kentaro Mochizuki et al.
Aurelien Pelissier et al.
Cytological diagnosis of follicular thyroid carcinoma (FTC) is one of the main challenges in the field of endocrine oncology due to the absence of evident morphological indicators. Morphological abnormalities in the nucleus are typically ke...
OpenDMS: An Open-Source Approach to Differential Mobility Spectrometry [0.03%]
开放源代码差 mobility 谱法/OpenDMS：开放式差 mobility 谱法
Dylan T Koch,Yevgeniy Belous,Bradley S Chew et al.
Dylan T Koch et al.
Differential mobility spectrometry (DMS) is a powerful gas-phase chemical analysis technique that separates ions based on their differential mobility in an asymmetric electric field, offering high sensitivity and rapid analysis crucial for ...
A Water-Soluble Probe for Visualizing Immune Activation for Microbial Resistance in Rice Crops via NIR-II Fluorescent Imaging [0.03%]
一种通过近红外荧光成像可视化水稻作物微生物抗性免疫激活的水溶性探针
Rong Li,Fang Zeng,Shuizhu Wu
Rong Li
Rice, a vital staple crop, provides sustenance for more than half of the global population, and its production needs to be increased to keep up with the growing global population, while plant diseases threaten the sustainability of rice pro...
Alberto Escarpa,Beatriz Jurado-Sánchez
Alberto Escarpa
Micromotors are microscale devices with enormous potential for analytical (bio)sensing due to autonomous motion capabilities in extremely small sample volumes or for guided detection in localized hard-to-reach areas. These unique features e...
Activatable Proximity-Labeled Fluorogenic Probe for Visualizing the Role of Estrogen in Regulating Liver Carboxylesterase Expression [0.03%]
可用于可视化雌激素在调节肝脏羧酸酯酶表达中作用的可激活近端标记荧光探针
Ningge Xu,Jianqiang Ge,Kaibo Huang et al.
Ningge Xu et al.
Estradiol (E2), the most potent form of estrogen, holds a central position in regulating physiological functions and influencing disease states across the female lifecycle. Carboxylesterases (CEs), as a widely distributed drug-metabolizing ...
Degradation of Reporter Molecules Imposes a Fundamental Limit of Detection on CRISPR Diagnostics [0.03%]
报告分子的降解对CRISPR诊断的基本检测限施加了根本限制
Alexandre S Avaro,Andrew D Griffiths,Juan G Santiago
Alexandre S Avaro
The sensitivity of CRISPR-Cas systems used for molecular diagnostics remains a major bottleneck in the adoption of this technology. The vast majority of CRISPR-based assays use dually labeled, single-stranded reporters and fluorescence sign...
Integrated Wearable Sensors Based on Sweat-Driven Hydrovoltaic Chips for Metabolite and Electrolyte Monitoring [0.03%]
一种基于汗液发电芯片的集成式可穿戴传感器用于代谢物和电解质监测
Zhechen Zhang,Yuetong Tian,Shujia Wang et al.
Zhechen Zhang et al.
Wearable integrated sensors enable the continuous measurement of useful biomarkers without any additional equipment or accessories. However, the limited variety of ion-selective electrodes restricts their range of applications. Furthermore,...
Supramolecular Hydrogen-Bonding Networks Amplify Luminol/O2 Chemiluminescence by over 4000-Fold: Mechanistic Insights and Biosensing Application [0.03%]
超分子氢键网络放大鲁米诺/氧气化学发光超过4000倍：机制洞察及生物传感应用
Sipeng Tian,Baobing Tang,Mingzi Sun et al.
Sipeng Tian et al.
Classic luminol-H2O2 chemiluminescence (CL) systems are plagued by inherent self-decomposition, which compromises detection reliability. Although luminol-dissolved oxygen systems circumvent this issue, their ultralow reactivity necessitates...