FRAP4ICBS: FRAP Analysis Method to Evaluate Dominant Effects for Biomolecular Condensate Formation [0.03%]
用于评估生物分子凝聚体形成主效遗传位点的FRAP分析方法
Xiaotian Wang,Zhiguang Xiao,Jiahao Niu et al.
Xiaotian Wang et al.
Cells contain a wide variety of membrane-less organelles, whose formation mechanism is believed to be generally based on liquid-liquid phase separation (LLPS). In fact, condensate formation can involve more than one mechanism; interactions ...
CSU-MS2: A Contrastive Learning Framework for Cross-Modal Compound Identification from MS/MS Spectra to Molecular Structures [0.03%]
CSU-MS2：一种从MS/MS光谱到分子结构的跨模态化合物识别对比学习框架
Ting Xie,Hailiang Zhang,Qiong Yang et al.
Ting Xie et al.
Tandem mass spectrometry (MS/MS) is a cornerstone for compound identification in complex mixtures, but conventional spectral matching approaches face critical limitations due to limited library coverage and matching algorithms. To address t...
An Aggregation/Monomer-Based Probe for Monitoring Mitochondria-Lysosome Interactions during Cuproptosis [0.03%]
铜死亡过程中监测线粒体-溶酶体相互作用的聚合/单体探针
Cui Zhou,Jia-Tong Yan,Yi-Ting Chu et al.
Cui Zhou et al.
The interplay between lysosomes and mitochondria is essential for maintaining cellular function, and disruptions of their interaction have been implicated in the onset of various diseases. Small molecule fluorescent probes are powerful tool...
Sustainable Wearable Sensors for Plant Monitoring and Precision Agriculture [0.03%]
可持续性植物监测和精准农业穿戴式传感器
Samiris Côcco Teixeira,Nathalia O Gomes,Taíla Veloso de Oliveira et al.
Samiris Côcco Teixeira et al.
Wearable sensors are emerging and innovative tools in the realm of agriculture, offering new opportunities for sustainable plant monitoring practices. This perspective explores wearable sensor technology in plant monitoring to promote envir...
Rapid Screening of Single-Atom Catalyst Synthesis Conditions Using ToF-SIMS and Facet-Dependent Single-Crystal Substrates [0.03%]
基于ToF-SIMS和晶面依赖单晶衬底的单原子催化剂合成条件的快速筛选法
Juejing Liu,Yining Wang,Ping Chen et al.
Juejing Liu et al.
Single-atom catalysts (SACs) offer superior catalytic performance compared with traditional nanoparticle catalysts but are challenging to develop because of the need for extensive optimization and specialized characterization techniques. Th...
Data Fusion Enhanced High-Dimensional SERS Fingerprints Construction via Dual-Wavelength and Multisubstrate Strategy for Precise Wastewater Identification [0.03%]
基于双波长和多元策略的废水电磁指纹图谱的融合增强构建及废水精准识别
Xueqing Wang,Lan Wei,Fan Li et al.
Xueqing Wang et al.
It is well-known that traditional label-free surface-enhanced Raman spectroscopy (SERS) can capture fingerprint information on analyte, providing a foundation for target identification and differentiation. However, the conventional one-dime...
Quantification of Endogenous Steroids and Hormonal Contraceptives in Human Plasma via Surrogate Calibration and UHPLC-MS/MS [0.03%]
基于代理校正的超高效液相色谱-质谱法检测人血浆中的内源性类固醇和激素避孕药
Min Su,Bernhard Drotleff,Tamara Janker et al.
Min Su et al.
Quantifying endogenous and exogenous steroids at low concentrations in biological matrices remains a major analytical challenge. Immunoassay-based diagnostics are limited by cross-reactivity, particularly at low levels, prompting a shift to...
Levodopa Sensing with a Nanosensor Array via a Low-Cost Near Infrared Readout [0.03%]
基于低成本近红外读出的左旋多巴纳米传感器阵列检测技术
Jan Stegemann,Matthias Niklas Augustin,Julia Ackermann et al.
Jan Stegemann et al.
Near infrared (NIR) signals are beneficial for biomedical applications due to reduced light absorption, scattering, and autofluorescence in this range, which promises higher signal-to-noise ratios (SNR). Single-walled carbon nanotubes (SWCN...
Synergistic Strain and Ligand Effects Boosting the Activity of Pt-Based Peroxidase Nanozymes for Femtomolar-Level Colorimetric Immunoassay of Protein Biomarkers [0.03%]
协同应变和配体效应增强Pt基过氧化物酶纳米酶的活性以实现蛋白质生物标志物的飞摩尔级比色免疫测定
Han Zhang,Yan Zhang,Xiang Peng et al.
Han Zhang et al.
Sensitive detection of protein biomarkers is crucial for advancing biomedical research and clinical management. Although colorimetric enzyme-linked immunosorbent assays (CELISAs) have been widely recognized as a benchmark technique for prot...
A Novel Electrochemiluminescence Sensor for Sensitive Detection of Estriol Based on "Three-in-One" Nanocomposite [0.03%]
一种基于“三合一”纳米复合材料的雌三醇电致化学发光传感器
Shuyue Xing,Xuejing Liu,Dawei Fan et al.
Shuyue Xing et al.
In this study, chemically polymerized luminol-hydrogen-bonded organic framework (CpL-HOF) is used as the efficient luminophore and POMs@MOFs as the quencher to construct the electrochemiluminescence (ECL) sensor for the ultrasensitive detec...