Tandem Elemental Analysis of Chang'e-6 Lunar Soil Samples Using X-ray Fluorescence and Femtosecond Laser Ablation Inductively Coupled Plasma Mass Spectrometry [0.03%]
基于X射线荧光和飞秒激光剥蚀等离子体质谱的嫦娥六号月壤元素分析
Ding-Shuai Xue,Yan-Hong Liu,Shun Guo et al.
Ding-Shuai Xue et al.
The Chang'e-6 (CE6) lunar mission returned the first lunar soil samples from the far side of the Moon in June 2024. We analyzed 10 major elements, one minor element, and 31 trace elements in two CE6 lunar soil samples using a tandem X-ray f...
Molecule-Responsive SERS Sensors for Urine Diagnosis of Kidney Diseases Enhanced by Neural Networks [0.03%]
基于神经网络增强的分子型尿检肾病表面增强拉曼传感器
Jiaqi Wang,Sijun Huang,Fanxiang Meng et al.
Jiaqi Wang et al.
Early diagnosis of kidney disease is crucial for treatment and prognosis. Compared with kidney biopsy, a noninvasive urine-based diagnosis method of kidney disease can be more convenient and less painful for patients. Urine is closely assoc...
Deciphering the Effect of Protein on Different Types of Target Signals in SERS Detection [0.03%]
基于SERS技术的蛋白质对不同基底信号影响机理的研究
Shuna Mi,Yuhang Du,Shaofeng Yuan et al.
Shuna Mi et al.
The matrix effect remains a significant challenge for the practical application of surface-enhanced Raman spectroscopy (SERS), with proteins being one of the most common interfering components. In this study, melamine (strong SERS signals, ...
A Multifunctional Tetrahedral DNA Nanostructure for the Simultaneous Sensitive Detection and Imaging of miRNA and Zinc Ions in Living Cells [0.03%]
用于活细胞中miRNA和锌离子的同时灵敏检测与成像的多功能四面体DNA纳米结构
Qinghong Jiang,Jie Zhou,Yuwei Sha et al.
Qinghong Jiang et al.
In this study, a multifunctional tetrahedral DNA nanostructure (MTDN) was constructed by assembling different functional modules for the simultaneous sensitive detection and imaging of targets miRNA-21 and Zn2+ in living cells related to li...
NIR-II Plastic Particles for Monitoring Intestinal Motility and Microplastic Deposition in Mice [0.03%]
用于监测小鼠肠道运动和微塑料沉积的近红外II区塑料颗粒
Xinxin Tian,Yiqing Yang,Wenjie Gao et al.
Xinxin Tian et al.
Plastic products are widely used in daily life, leading to the pervasive presence of microplastics, which have posed great threats to human health. However, the relative lack of methods to observe the movement and distribution of microplast...
Real-Time Detection of Hydrogen and Ammonia Isotopologues for Impurity Removal and Recovery of Tritium [0.03%]
氢同位素和氨同位素实时检测去除杂质并回收氚原子的技术
John T Kelly,Christopher J Koch,Tyler Guin et al.
John T Kelly et al.
To accommodate gas measurements for impurity removal and recovery of tritium, a silver-coated optical or waveguide is employed for collecting Raman scattered signals to determine relative hydrogen and ammonia isotopologue populations in rea...
Slice-Inference-Assisted Lightweight Small Object Detection Model for Holographic Digital Immunoassay Quantification [0.03%]
用于全息数字免疫测定定量的切片推理辅助轻量级小目标检测模型
Minjie Han,Junpeng Zhao,Weiqi Zhao et al.
Minjie Han et al.
Sensitive and cost-effective detection methods utilizing portable equipment are crucial for applications in food safety inspection, environmental monitoring, and clinical diagnosis. In this study, we propose a sliced inference-assisted ligh...
Improving the Prediction of Antioxidant Activity by Identifying High-Probability Conformations with NMR [0.03%]
通过NMR识别高概率构象以改善抗氧化活性预测的影响因素分析研究
Emily C Heider,Paula Grace Nickles,Dirk Emde et al.
Emily C Heider et al.
A single-experiment NMR methodology was recently proposed for characterizing chemical structures in solution. This approach employs measured and computed one-bond carbon-carbon J-couplings to establish atomic connectivity, molecular conform...
Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography [0.03%]
在线二维液相色谱辅助的内源性蛋白复合物原位自上而下蛋白质组学分析
Matthew S Fischer,Holden T Rogers,Emily A Chapman et al.
Matthew S Fischer et al.
Protein complexes are essential for virtually all biological processes, yet their structural characterization remains a major challenge due to their heterogeneous, dynamic nature and the complexity of the proteome. Native top-down mass spec...
Selective and Sensitive Dopamine Detection Using the Pictet-Spengler Reaction for Surface-Enhanced Raman Scattering [0.03%]
基于表面增强拉曼散射的Pictet-Spengler反应的选择性和敏感的多巴胺检测法
Kunle Li,Xinyu Zheng,Jiancheng Feng et al.
Kunle Li et al.
Dopamine (DA) presents significant challenges for direct quantification using surface-enhanced Raman scattering (SERS) due to its relatively small Raman cross section and the complexity of biological fluids. To address these limitations, th...