Multicolumn Two-Dimensional Liquid Chromatography Screening Platform for Stereopeptidomics and Application to Antimicrobial Peptide Polyene and Lipopeptide [0.03%]
用于立体肽组学的多柱二维液相色谱筛选平台及在抗菌肽聚烯和脂肽中的应用
Cornelius Knappe,Simon J Jaag,Taulant Dema et al.
Cornelius Knappe et al.
Therapeutic peptides are a rapidly growing field in research and drug development. While the majority of natural and synthetic therapeutic peptides have l-amino acids as building blocks, d-amino acid-containing peptides are found frequently...
Parts-per-Trillion-Level Methane Detection Based on Light-Induced Thermoelastic Spectroscopy with Extended Optical Path Absorption [0.03%]
基于光致热弹光谱法的ppt级甲烷检测技术研究
Yanjun Chen,Xiaorong Sun,Hanxu Ma et al.
Yanjun Chen et al.
This paper describes a highly sensitive methane (CH4) sensor utilizing light-induced thermoelastic spectroscopy (LITES), which incorporates a multipass cell (MPC) with a dense spot configuration and a self-designed round-tip quartz tuning f...
4D-Printed Redox-Responsive Needle-Flow Reactors Enabling Online Quantitative Profiling of Living Rat Brain Extracellular Lactate and Glucose [0.03%]
一种可在活体大鼠大脑中对脑外液乳酸和葡萄糖进行在线定量检测的四维打印氧化还原响应注射器流式反应装置
Hsiao-Chu Chiu,Cheng-Kuan Su
Hsiao-Chu Chiu
Various assays are performed based on the use of oxidase-based derivatization schemes coupled with chromogenic or fluorogenic reagents and spectrometric determination. To enable online quantitative profiling of living rat brain extracellula...
Small-Molecule Binding-Guided Nucleic Acid Amplification and Its Ultrasensitive Electrochemical Detection of Aflatoxin B1: A Split Aptamer Ligation Chain Reaction via Click Chemistry [0.03%]
基于小分子结合的核酸扩增及其对黄曲霉毒素B1超灵敏电化学生物传感器：利用“点击化学”的拆分型适配体连接等温放大检测体系的研究
Jin-Yuan Chen,Jia-Yi Li,Liang-Yong Yang et al.
Jin-Yuan Chen et al.
The robustness and sensitivity of nucleic acid amplification (NAA)-integrated aptasensors for the detection of small molecules are currently challenged by the strict enzymatic conditions and low efficiency of strand displacement. Herein, we...
Liquid-Phase Barrier Modified Nitrocellulose Membrane: A Strategy for Boosting Chemiluminescent Detection in Lateral Flow Assays [0.03%]
液相屏障改性硝酸纤维素膜：侧向流动检测试剂盒中化学发光检测的新策略
Zixuan Ren,Weimin Xu,Li Yang et al.
Zixuan Ren et al.
Lateral flow assay (LFA), as one of the most well-known methods in point-of-care testing platforms, has attracted great interest in disease detection due to its low cost, portability, ease of use, and short response time. However, the sensi...
Differentiating Molecular Weights of Supramolecular Polymers in Lower Monomer Concentrations by Coreaction Accelerator-Regulated Electrochemiluminescence [0.03%]
通过核心作用加速器调控的电化学发光区分低单体浓度下单分子聚合物分子量
Jingke Pan,Qianxi Duan,Zhengqiong Lai et al.
Jingke Pan et al.
Nuclear magnetic resonance is the most conventional approach to characterizing the molecular weight (Mw) of supramolecular polymers (SPs) at high monomer concentrations. However, it remains a great challenge to determine SPs with lower Mw v...
Serum-Based Detection of Pancreatic and Ovarian Cancer via a Nanoparticle-Enhanced Fluorescence Array and Machine Learning [0.03%]
基于纳米粒子增强荧光阵列和机器学习的血清胰腺癌和卵巢癌检测方法
Violeta Morcuende-Ventura,Oscar Sánchez-Gracia,Natalia Abian-Franco et al.
Violeta Morcuende-Ventura et al.
Background: Early detection of oncological diseases such as pancreatic ductal adenocarcinoma (PDAC) and ovarian cancer (OV) is pivotal for successful treatment but remains a significant challenge due to the lack of sensitive and specific di...
Yijing Yang,Ruilin Wang,Qianchen Rui et al.
Yijing Yang et al.
3D light manipulation of water droplets at low temperatures via a local photothermal effect presents a fundamental challenge. Herein, we propose a novel light strategy for 3D manipulation of a water droplet in an immiscible oil phase using ...
Orthogonal Dual-Signal Cooperative Sensing Platform via CDs@MIPs-Mediated Fluorescence Enhancement and Aptamer-Liposome Fusion-Triggered Photoelectrochemical Amplification [0.03%]
基于荧光增强和适配体脂质体融合触发的光电化学放大作用的正交协同传感平台
Yingzhuo Shen,Jianzhou Feng,Zheng Wang et al.
Yingzhuo Shen et al.
The development of dual-recognition and multisignal transduction sensing strategies is critical for achieving precise identification and ultrasensitive detection of small molecule contaminants. In this work, a fluorescence-photoelectrochemi...
A Microfluidic Device to Realize Electrochemically Controlled SERS Detection in HPLC [0.03%]
一种电化学控制的HPLC-SERS微流控器件
Maximilian E Blaha,Julius Schwieger,Rico Warias et al.
Maximilian E Blaha et al.
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for vibrational spectroscopy, but analyzing mixtures in solution remains challenging due to spectral overlap. Integrating SERS with a separation method, such as high-perform...