Haiqian Lin,Congyu Wang,Ting Hou et al.
Haiqian Lin et al.
Conventional luminol chemiluminescence (CL) is typically generated in luminophore solutions, but its development and practical application are constrained by the inherent limitations of coreactants. Herein, inspired by contact-electro-catal...
Targeted and Nontargeted Detection and Quantitation of Arsenolipids in a Tuna Fish Reference Material (BCR-627) Using Reversed-Phase HPLC with High-Resolution Electrospray Mass Spectrometry and Inductively Coupled Plasma Mass Spectrometry [0.03%]
Margarita Kapsi,Evangelos Stergiou,Chrysovalanto Drakonaki et al.
Margarita Kapsi et al.
This study demonstrates the development of advanced mass spectrometric methodologies suitable for targeted and nontargeted arsenolipid (AsLp) determination in a tuna fish reference material (BCR-627) certified for its arsenobetaine, dimethy...
Zhong Wang,Yanru Ding,Cai Gao et al.
Zhong Wang et al.
Accurate identification of amino acids within peptides and proteins is essential for understanding physiological and pathological mechanisms. While nanopore-based ionic current measurements have enabled single-molecule discrimination of the...
Nonsymmetrical Near-Infrared Rhodamines for Carboxylesterase-Activatable Tumor Imaging and Photodynamic Therapy [0.03%]
Song Zhou,Hai-Bo Yi,Li-Juan Tang et al.
Song Zhou et al.
Fluorophores with large Stokes shifts, desired quantum yields, and tunable near-infrared (NIR) absorption/emission wavelengths are useful for developing activatable probes for bioimaging and biomedical applications. However, very few fluoro...
Uncertainty Exploration of Deep Learning Enabled Fast Multidimensional NMR Spectroscopy of Proteins [0.03%]
Haolin Zhan,Zhongfu Huang,Chaojie Xing et al.
Haolin Zhan et al.
Deep learning (DL) has shown great promise in accelerating multidimensional NMR spectroscopy with high-accuracy reconstruction. Nevertheless, its practical deployment requires not only high accuracy but also reliability evaluations along wi...
Winnie Uritboonthai,Aries Aisporna,Linh Hoang et al.
Winnie Uritboonthai et al.
Multiple reaction monitoring (MRM) enables robust and sensitive quantification but traditionally requires predefined precursor-fragment transitions, limiting its use in discovery-driven studies. Here, we describe untargeted/micro/universal ...
Facile Deposition of Metal Films on a Diamond Protected Silicon Window for In Situ ATR-IR Spectroelectrochemistry across a Wide pH Range [0.03%]
Wei-Yi Zhang,Xindi Xu,Yunfang Yan et al.
Wei-Yi Zhang et al.
Facile fabrication of thin metal films on protected silicon internal reflection elements (IREs) is essential for electrochemical attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) in various pH electr...
Dose-Dependent Inhibition of Protein Glycosylation Reveals Crosstalk between Glycosylation and Phosphorylation in EGF Signaling Pathways [0.03%]
Hongyi Liu,Ding Chiao Lin,Yingwei Hu et al.
Hongyi Liu et al.
Protein glycosylation and phosphorylation play critical roles in regulating diverse cellular processes, yet their interplay remains underexplored. This study employed dose-dependent glycosylation inhibition to investigate the function of gl...
Hydroxylated Bimetallic MOF Dual-Mode Biosensor: A Platform for Rapid Screening and Accurate Quantitative Detection of Free Bilirubin [0.03%]
Lu-Ying Wang,Yan Cheng,Shuang Yin et al.
Lu-Ying Wang et al.
Elevated levels of free bilirubin (f-Bil) in the blood can cause neonatal brain damage, making the development of rapid and accurate detection methods critical for diagnosing neonatal jaundice. This study targeted the structural characteris...
Novel Deep-Learning Unsupervised Domain Adaptation Method for Mitigating Batch, Strain, and Instrument Variations to Enhance Raman Spectroscopy-Based Bacterial Pathogen Identification [0.03%]
Zhe Zhang,Yiwen Xu,Siyu Meng et al.
Zhe Zhang et al.
The escalating threat of antibiotic resistance demands a rapid and accurate pathogen identification. While Raman spectroscopy combined with deep learning supports fast detection, model robustness remains compromised by domain shifts arising...