Triple Synergistic Antifouling Conductive MOFs via Cathodic Electrodeposition for Electrochemical Sensor [0.03%]
通过阴极电沉积构建三重协同抗污导电MOFs用于电化学传感器
Haitong Zhang,Yue Zhao,Yifan Fu et al.
Haitong Zhang et al.
Electrochemical sensors face severe protein biofouling in complex biological matrices. Traditional antifouling coatings struggle to balance sensitivity with antifouling performance, as it is difficult to simultaneously achieve high conducti...
PiezoFusion Enables Physically Driven Sample-to-Answer Nucleic Acid Testing from Complex Samples [0.03%]
基于压电的样品到答案核酸检测技术PiezoFusion：从复杂样本中进行物理驱动式的核酸提取及检测
Kaiyuan Jia,Fengzhen Yang,Zeyu Wen et al.
Kaiyuan Jia et al.
Complex food samples remain challenging inputs for point-of-need nucleic acid testing because clarification, cell disruption, and nucleic acid purification must be integrated into a compact, low-intervention, and contamination-resistant wor...
Dual-Target Immunosensor Based on SERS for Simultaneous Sensing of Hemoglobin and Glycated Hemoglobin in Human Whole Blood [0.03%]
一种基于SERS的双目标免疫传感器同时检测人全血中的血红蛋白和糖化血红蛋白
Hao Jiang,Shanshan Xu,Shi-Ying Fu et al.
Hao Jiang et al.
Glycated hemoglobin (HbA1c) refers to the product of the nonenzymatic reaction of hemoglobin (Hb) with glucose and is clinically routine for assessing long-term glycemic control by monitoring its proportion relative to total Hb. However, ex...
Isocitrate Dehydrogenase Mutation Assessment in Human Glioma Using Desorption Electrospray Ionization-Multiple Reaction Monitoring [0.03%]
人胶质瘤中异柠檬酸脱氢酶突变的解吸电喷雾离子化-多重反应监测法检测评估
Mahdiyeh Shahi,Diogo Moniz Garcia,Alfredo Quiñones-Hinojosa et al.
Mahdiyeh Shahi et al.
The mutation status of isocitrate dehydrogenase (IDH) in glioma patients has diagnostic and prognostic significance but is available only after surgery. Rapid and sensitive intraoperative molecular diagnosis is essential for distinguishing ...
Breaking the Sensitivity-Sustainability Trade-Off in Heavy Metal Sensing: A DNA Breathing-Actuated Nanoprobe [0.03%]
突破重金属传感中灵敏度和可持续性的权衡：一种DNA呼吸激活的纳米探针
Yingxin Ji,Zheng Shen,Tohru Takarada et al.
Yingxin Ji et al.
Currently established heavy metal sensors based on plasmonic nanoparticles often face an intractable trade-off between high sensitivity and sustainability, a dilemma that impedes their real-world application, particularly in resource-limite...
Online Energy-Resolved Mass Spectrometry Enables Differentiation of Glycosylation Sites and Sugar Moieties Supporting More Accurate Identification of Ginsenoside Isomers [0.03%]
在线能量分辨质量谱法可区分糖基化位点和糖类成分，有助于更准确地鉴定人参皂苷异构体
Yadan Zou,Yuan Li,Feiyang Yu et al.
Yadan Zou et al.
Structural characterization of natural saponins is highly challenging by tandem mass spectrometry, lacking evidence for differentiating multiple glycosylation sites and diverse sugar moieties. Optimal collision energy (OCE) in collision-ind...
Regioisomeric Covalent Organic Frameworks with Precisely Engineered Spatial Arrangement of Active Sites Enable Enhanced Electrochemiluminescence and Ultrasensitive Uranium(VI) Detection [0.03%]
具有精确工程化活性位点空间排列的区域异构共价有机框架增强电化学发光和超灵敏检测六价铀
Xun Wang,Qiao-Qiao Jiang,Ying-Ao Wang et al.
Xun Wang et al.
Covalent organic frameworks (COFs) offer precise spatial control over catalytically active sites due to their ordered, crystalline structures. This control directly governs site accessibility and interfacial charge transfer, both critical f...
A RuAAC-Based Fluorescent Labeling Strategy for Efficient Detection of Alkyne-Containing Natural Products [0.03%]
一种基于RuAAC的荧光标记策略高效检测含炔天然产物
Yan-Peng Liang,Rui Ma,Haixia Zhang et al.
Yan-Peng Liang et al.
Natural products (NPs) represent an indispensable reservoir for drug discovery, with alkyne-containing natural products (ANPs) exhibiting diverse biological activities. However, the efficient discovery of ANPs is severely hindered by low na...
Implantable Hydrogel Electrochemical Sensor for Early Warning and Fingerprinting of Environmental Pollutant Stresses in Plants [0.03%]
用于植物环境污染物压力的早期预警和识别的植入式水凝胶电化学传感器
Cheng Yu,Xiya Liu,Weiyan Wang et al.
Cheng Yu et al.
Ubiquitous environmental pollution exerts severe adverse impacts on plant growth, development, and yield, jeopardizing global food security as well as human life and health. Traditional plant health monitoring relies on phenotypic observati...
Fluorinated Core-Shell Metal-Organic Framework-Based Dual-Activated 19F MRI Nanoprobes for In Vivo Visualization of the Tumor Microenvironment [0.03%]
基于含氟核心壳金属有机骨架的双激活纳米探针用于活体肿瘤微环境19F MRI成像
Yifan Fan,Yuanxi Zheng,Xiaoqin Chi et al.
Yifan Fan et al.
In vivo simultaneous visualization of the dynamic changes in biomarkers within the tumor microenvironment (TME) is crucial for elucidating the mechanisms underlying tumor initiation and progression and providing pivotal insights for tumor m...