Dual-Mode Wheat Germ Agglutinin Labeling - A Versatile Cell Segmentation Strategy for High-Resolution LA-ICP-TOFMS Bioimaging [0.03%]
双模式刀豆蛋白A标记细胞分割策略在高分辨激光 ablative ICP-MS 生命科学成像中的应用研究
Claude Molitor,Martin Schaier,David Loibnegger et al.
Claude Molitor et al.
Single-cell analysis by laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOFMS) enables high-resolution mapping of elemental distributions and cellular phenotypes. Segmentation of individual cells necessita...
Experimental and Theoretical Insights into Nanoscale AFM-IR Imaging of Complex Heterogeneous Structures [0.03%]
纳米级AFM-IR显微镜在复杂异构结构材料表征中的实验与理论研究进展
Yide Zhang,Ufuk Yilmaz,Artem S Vorobev et al.
Yide Zhang et al.
Nanoscale chemical imaging enabled by atomic force microscopy-infrared spectroscopy (AFM-IR) provides valuable insights into the complex structures and chemical compositions of materials and biological samples. While AFM-IR has been applied...
Zuyi Zhang
Zuyi Zhang
For the analysis of a structural distribution in a range of thicknesses comparable with the wavelengths in the visible region of light, infrared attenuated total reflection (ATR) was derived on the basis of the wave vector and Poynting vect...
Enabling Alkaline Scanning Electrochemical Cell Microscopy (SECCM) for the Study of Water-Splitting Electrocatalysts [0.03%]
用于研究水分解电催化剂的碱性扫描电解化学电池显微镜(SECCM)
Prachi Janjani,Harry B Swan,Leeling Dy et al.
Prachi Janjani et al.
Spatially resolved electrochemical techniques are critical for advancing nanoscale structure-function studies of electrocatalytic materials, enabling direct correlation between the surface structure and activity of, for example, advanced wa...
Intramolecular Proximity-Induced Amplification for Accurate Imaging of Glycosylated RNAs in Living Cells and Zebrafish [0.03%]
用于活细胞和斑马鱼中糖基化RNA精确成像的分子内邻近放大技术
Zan Gong,Panpan Yuan,Yuqing Gan et al.
Zan Gong et al.
As emerging molecules, glycosylated RNAs (glycoRNAs) have been demonstrated to participate in cellular communication, developmental signaling pathway regulation, and immune recognition. Revealing the dynamics of glycoRNAs during biological ...
A Modular DNA-Assembled Nanopipette (mDNP) Platform for Spatially Confined Single-Cell Nuclear Detection of Methyltransferase Activity [0.03%]
一种模块化的DNA组装纳米移液管(mDNP)平台，用于在空间受限的单个细胞核中检测甲基转移酶活性
Juan Song,Chao-Wei Xia,Xian Zhang et al.
Juan Song et al.
Single-cell epigenetic regulation relies on spatially organized enzymatic activities within nuclear compartments, which establish DNA methylation patterns that dictate gene expression and cellular identity. Given this spatial organization, ...
Deep Learning-Based Shape Classification for Hyperspectral-Imaged Microplastics [0.03%]
基于深度学习的高光谱微塑料图像形状分类方法
Yuanli Liu,Guohan Zhao,Fan Liu
Yuanli Liu
The shape of microplastics (MPs) matters. Yet, the expert-based shape classification is labor intensive, time consuming, and susceptible to human biases. In this study, we investigated deep learning-based approaches for automating shape cla...
Multiomics Analysis of Dried Plasma Spots Using Stable Isotope Internal Standards for Biomarker Discovery [0.03%]
基于稳定同位素内标的干血浆斑点多组学分析用于生物标志物发现
Wenqian Li,John R Koethe,Curtis L Gabriel et al.
Wenqian Li et al.
A comprehensive analytical strategy for multiomics analysis of dried blood spots (DBS) has been developed, featuring prespotted stable isotope internal standards (SIIS) for enhanced quantitation. The method combines an optimized Folch extra...
Magnetic MOF-Assisted Radical Polymerization Signal Amplification in Homogeneous System for Ultrasensitive PEC-EC Dual-Mode Detection of Caspase-3 Activity [0.03%]
磁性MOF辅助自由基聚合信号放大均相体系用于Caspase-3活化超灵敏光电化学/电化学双模式检测
Huan Wang,Yiyuan Yang,Cuicui Du et al.
Huan Wang et al.
Enhancing detection sensitivity and reliability is critical in analytical chemistry, particularly for disease diagnosis and biological analysis. Innovative radical polymerization signal amplification strategies, integrated with dual-mode se...
DNA Multiway Junction Based Lateral Flow Assay for Visualized Detection of Different Types of Targets [0.03%]
基于DNA多路连接的 lateral flow 试纸条用于不同种类目标分子的视觉检测
Siting Fu,Ping Li,Pengxiao Fu et al.
Siting Fu et al.
Lateral flow assay owns advantages of easy operation, visual detection, and portable use. However, since the strip fabrication requires specific nanomaterial modification, zones pretreating/spraying, and particular capture unit immobilizati...