Universal Integration of Liquid Crystals with Inorganic Inverse Opals: Robust and Customizable Regulation for Optical Sensing [0.03%]
Anping Zhu,Yanhui Wang,Yang Qiu et al.
Anping Zhu et al.
Liquid crystal (LC)-based biosensors are attractive for translating subtle molecular interactions into optical signals, but their practical application is hindered by inherent fragility and limited LC regulation principles. Here, we report ...
Chiral Chromatography Resolution Can Be Enhanced by Using Microfluidic Precision Manufactured Macroporous Silica Microspheres [0.03%]
Jikai Chen,Hanchen Cao,Ruichen An et al.
Jikai Chen et al.
Among others, polysaccharide-functionalized macroporous silica microspheres are predominantly employed as chiral stationary phases (CSPs) in HPLC. Conventionally, such macroporous phases are prepared through pore-widening post-treatments of...
Noor Ul Huda,Rana Zaki Abdul Bari,Muhammad Abdullah Javed et al.
Noor Ul Huda et al.
High-Speed, Label-Free Antimicrobial Susceptibility Testing in Picoliter Droplets: Combining Cage-Based Phase Contrast Microscopy with YOLO-SAM Algorithm [0.03%]
Chenyi Lei,Lulu Xu,Chufan Xiao et al.
Chenyi Lei et al.
Rapid rise in antimicrobial-resistant bacteria highlights the urgent need for interventions to combat antimicrobial resistance (AMR). Antimicrobial susceptibility testing (AST) is crucial for antibiotic discovery and efficacy testing. Howev...
Protein Melting Biosensors for Label-Free and Self-Reporting of Iron-Binding Proteins and Iron Ion [0.03%]
Na-Na Sun,Qin-Feng Xu,Yu-Jie Wei et al.
Na-Na Sun et al.
Protein fluorescence sensing holds great promise for food safety, disease diagnosis, and environmental monitoring. Nevertheless, the synthesis of specific fluorescent dye probes is usually necessary, which significantly increases the cost a...
Three-Principal-Substrate SERS Profiling Enables Reliable Screening of Serum Biomarkers: A General Approach [0.03%]
Xuecheng Dong,Zhengyuan Zhao,Yuanhao Zheng et al.
Xuecheng Dong et al.
Discovery of biomarkers is crucial for the early diagnosis and precision treatment of cancer. Traditional methods (genomics and metabolomics, etc.) are low-throughput, expensive, and require complex sample processing. Surface-enhanced Raman...
Zheng Fang,Yaya Hao,Xiaolei Zuo et al.
Zheng Fang et al.
Extracellular vesicle (EV)-mediated communication is tightly regulated by local pH, which governs vesicle biogenesis, cargo release, and membrane fusion. Accurate and context-specific pH sensing is therefore crucial for elucidating EV funct...
Understanding Analytical Methods Assessment Metrics: A Two Decades' Simple and Comprehensive Review (2006─2025) [0.03%]
Adel Ehab Ibrahim,Samy G Alamir,Nesrine Abdelrehim El Gohary et al.
Adel Ehab Ibrahim et al.
Fourier Deconvolution Multiplexing Boosts Ion Throughput in Pinhole-Interfaced GC-IMS/MS for Synchronous Peak Identification [0.03%]
Xiuqing Zheng,Jianna Yu,Mengting Huang et al.
Xiuqing Zheng et al.
Gas chromatography-ion mobility spectrometry has been recognized as a rapid, sensitive, portable approach at low cost in food safety analysis, environmental monitoring, and security screening. However, the peak identification remains a majo...
Process-Decoupled Operando Molecular Characterization of Liquid-Phase Lignin Depolymerization by Online High-Resolution Mass Spectrometry [0.03%]
基于在线高分辨质谱的液相木质素解聚过程解耦原位分子表征
Zhongyue Zhou,Linyu Zhu,Xintong Xiao et al.
Zhongyue Zhou et al.
As an abundant, renewable aromatic resource, lignin remains underutilized due to its complex and recalcitrant structure. Molecular-level elucidation of liquid-phase catalytic depolymerization of technical lignin is further hindered by struc...