One-Pot and Enzyme-Free Analysis of mRNA Vaccines Based on a Double Amplification System Featured by Adjustable Structure MNAzyme [0.03%]
一种基于结构可调MNAzyme的双扩增体系的一锅、无酶型式mrna疫苗分析方法
Feifan Yin,Murilege Chao,Jinhua Chen et al.
Feifan Yin et al.
mRNA vaccines have been developed as a captivating and highly prospective avenue for the advancement of immunotherapy. With the advancement of antitumor mRNA vaccines into clinical trials, it is important to monitor the levels of nucleic ac...
Palindrome-Mediated Isothermal Cascade DNA Amplification and Effortless Nanosignal Transduction for One-Pot and Ultrasensitive miRNA Sensing [0.03%]
palindrome介导的等温级联DNA放大及无与伦比的纳信号转导“一锅式”超灵敏微rna传感
Jintao Chen,Yuhui Shang,Yu Yang et al.
Jintao Chen et al.
In this work, we developed an ultrasensitive method for microRNA (miRNA) sensing based on palindrome-mediated isothermal cascade nicking/polymerization for DNA amplification and fluorescent copper nanoparticle (CuNP) generation for signal t...
Hydroxyl and Trifluoromethyl Radical Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides [0.03%]
用于探索单糖结合成分的蛋白羟基和三氟甲基自由基糖印法
Quadrat Yusuph,Sandeep K Misra,Hao Liu et al.
Quadrat Yusuph et al.
Carbohydrates are found in various forms in living organisms, both as free-standing glycans as well as glycoconjugates including glycoproteins, glycolipids, and glycosaminoglycans. These structures play crucial roles in many biological proc...
A Biosensor Platform for Detecting the Dissipation of Transmembrane Gradients in Single Liposomes [0.03%]
一种用于检测单个脂质体跨膜梯度耗散的生物传感器平台
Changcheng Zhang,Mark E Bowen
Changcheng Zhang
Pore forming proteins are a diverse collection of polypeptides, which share little structural or amino acid sequence homology and span several mechanistic classes. Their commonality lies in their ability to create transmembrane pores in bio...
Ultrasensitive Electrochemiluminescence Multiplex Immunoassays of Circulating Tumor Cells via Cerasomes within MXene-Modified Single-Electrode Electrochemical Systems [0.03%]
基于单电极的MXene修饰的介孔碳包金纳米球免疫分析体系用于循环肿瘤细胞的多重超灵敏化学发光免疫检测
Seyed Mohammad Reza Mortazavi,Morteza Hosseini,Guobao Xu et al.
Seyed Mohammad Reza Mortazavi et al.
Breast cancer (BC) remains one of the most prevalent malignancies worldwide. Notably, the primary cause of mortality is not the primary tumor itself but rather the spread of tumor cells to distant sites. Circulating tumor cells (CTCs), whic...
Advanced Spectroscopic Techniques for Lactose Crystallization Analysis: Investigating Water Participation in Crystal Morphology [0.03%]
乳糖结晶过程的高级光谱技术研究：水参与结品形态的变化规律
Fanghui Fan,Yuwen Ou,Hao Deng et al.
Fanghui Fan et al.
We provide an integrated strategy for scientists seeking to comprehend the participation of water in amorphous lactose crystallization and its impact on crystal morphology across different water activity (aw) levels and temperatures. Low-fi...
Molecular-Level Insights into TIMS-MS Separation of α/β-Estradiol Isomers: Synergistic Effects of Cyclodextrins and Metal Ions [0.03%]
分子水平上α/β-雌二醇异构体TIMS-MS分离机理研究：环糊精与金属离子的协同作用效应
Naisheng Wu,Fangling Wu,Sisi He et al.
Naisheng Wu et al.
This study presents a novel approach for the rapid and high-resolution separation of estrogen isomers (α/β-estradiol and estriol: α/β-E2/E3) using trapped ion mobility mass spectrometry (TIMS-MS). Systematically, evaluating cyclodextrin...
Net Enhanced 1H NMR Signals in Symmetric Molecules Produced via Heterogeneous Hydrogenation with Parahydrogen over Immobilized Metal Complexes [0.03%]
通过固载化金属配合物在多相氢化中利用顺氢气增强对称分子的网络增強型1H NMR信号研究
S V Babenko,I V Skovpin,D B Burueva et al.
S V Babenko et al.
Heterogeneous parahydrogen-induced polarization (PHIP) offers a pathway to generate pure hyperpolarized molecular agents devoid of toxic catalysts. While conventional hydrogenative PHIP relies on hydrogenation with parahydrogen (p-H2) and b...
MassVision: An Open-Source End-to-End Platform for AI-Driven Mass Spectrometry Imaging Analysis [0.03%]
MassVision：一种开源端到端平台 用于驱动质谱成像分析人工智能
Amoon Jamzad,Jade Warren,Ayesha Syeda et al.
Amoon Jamzad et al.
Mass spectrometry imaging (MSI) combines spatial and spectral data to reveal detailed molecular compositions within biological samples. Despite their immense potential, MSI workflows are hindered by the complexity and high dimensionality of...
Spiraling-Based Structural DNA Nanotechnology to Regulate the Orientation of Sticky Ends for Intelligent Assembly of In Vivo Targeting DNA Nanostructures [0.03%]
基于螺旋结构的DNA纳米技术调节粘性末端取向以实现体内靶向DNA纳米结构的智能组装
Hong Huang,Xiangru Chen,Chang Xue et al.
Hong Huang et al.
Homogeneous DNA nanostructures made entirely of DNA strands have attracted great attention in the biomedical and nanomedical fields. However, the intrinsic vulnerability of native nucleic acids to enzymatic degradation limits their practica...