Fast Screening of Circulating Tumor Cells in Blood Samples by Sialic Acid Recognition and Microfluidic Chip-Single-Cell ICP-MS: A Breakthrough in Non-invasive Cancer Diagnosis [0.03%]
基于唾液酸识别和微流控芯片-单细胞ICP-MS技术的血液样品循环肿瘤细胞快速筛选：一种突破性的无创癌症诊断方法
Junrong Ma,Man He,Beibei Chen et al.
Junrong Ma et al.
Circulating tumor cells (CTCs) hold promise for non-invasive cancer diagnostics, but current detection methods face challenges like white blood cell (WBC) interference, high false negative rates, low throughput, and operational complexity. ...
Smartphone-Integrated Fluorescent Sensing Array Assembled from Lanthanide Metal-Organic Frameworks for Rapid Identification and Differentiation of Antibiotics in Daily Foods [0.03%]
一种基于镧系金属有机骨架的智能手机集成荧光传感阵列用于日常食物中抗生素的快速识别及分类检测技术
Wenxi Zhang,Yuxuan Song,Yanjie Lv et al.
Wenxi Zhang et al.
The excessive use of antibiotics in human healthcare and animal farming presents significant risks to ecosystems and human well-being, prompting the development of diverse detection technologies. Fluorescence sensing arrays have garnered co...
Infrared Spectroscopy with Variable Decomposition Level Dual-Tree Complex Wavelet Transform for Quantification of Air Pollutants [0.03%]
基于可变分解尺度的二维复小波变换红外光谱定量分析空气污染物研究
Yusheng Qin,Xin Han,Xangxian Li et al.
Yusheng Qin et al.
Open-Path Fourier Transform Infrared Spectroscopy (OP-FTIR) is a key active remote sensing technology for detecting and identifying atmospheric pollutants. However, accurately characterizing gaseous pollutants under open-path conditions pre...
Spatiotemporally Traceable Peptide Self-Assemblies for Mitochondrial-Specific Dysfunction [0.03%]
时空可追踪肽自组装体用于线粒体特异性功能障碍
Xia Wu,Hao Zhang,Mingxuan Li et al.
Xia Wu et al.
Peptide self-assembly has emerged as a highly regarded strategy for developing functional agents to control cellular fate. However, due to the complexity of intracellular environments, achieving spatiotemporally traceable organelle localiza...
Internal Calibration without Internal Calibrants by Mass Difference Analysis in FT-ICR Mass Spectrometry [0.03%]
傅里叶变换离子回旋共振质谱中无需内标物的基于质量差值的内部校正方法
Ryan P Rodgers,Christopher L Hendrickson,Christopher A Holder Montenegro et al.
Ryan P Rodgers et al.
We report an improved, fully automated method of mass spectral calibration that relies on mass differences instead of internal calibrants. First, we introduce the mass difference spectrum and note that confident elemental formulas can be as...
Advanced Method Optimization with Categorical and Constrained Continuous Parameters [0.03%]
基于分类和有约束连续参数的高级方法优化
Stephanie N Gamble,Caroline O Granger,Joseph M Mannion
Stephanie N Gamble
Traditional approaches to analytical method optimization (e.g., univariate and "guess-and-check") can be time-consuming, costly, and often fail to identify true optima within the parameter space. Previous work defined and implemented a gene...
Machine Learning-Driven Dual-Recognition Magnetic Imprinted Polymers: Host-Guest/Aptamer Synergy Enabling Ultrasensitive Chloramphenicol Detection [0.03%]
机器学习驱动的双识别磁印聚合物：宿主-客体/适配体协同作用，实现氯霉素的超灵敏检测
Jiaming Zhang,Yanxia Ma,Jinbo Cao et al.
Jiaming Zhang et al.
To address the challenges in detecting chloramphenicol (CAP) in complex food matrices, this study developed a magnetic solid-phase microextraction coupled with a high-performance liquid chromatography (MSPME-HPLC) system that integrates mac...
Highly Selective Dual-Modal Probe for Photoacoustic and Magnetic Resonance Imaging of the Labile Cu2+ Pool in the Liver [0.03%]
一种用于肝组织中不稳定的Cu2+池的双模式成像探针用于光声和磁共振成像
Zhaoqing Liu,Lei Zhang,Sha Li et al.
Zhaoqing Liu et al.
Copper ions (Cu2+) play vital roles in human physiology, and their dyshomeostasis is associated with diseases such as hepatocellular carcinoma, Alzheimer's disease, and Wilson's disease. Cu2+ imaging technologies facilitate the investigatio...
High Sensitivity and Selectivity Electrochemiluminescence Sensor Based on the Regulation of Wettability in the Microchannel for the Detection of Glutathione in the Rat Brain [0.03%]
基于微通道润湿性调控的高灵敏高选择性的谷胱甘肽电致化学发光传感器用于检测大鼠脑组织中的谷胱甘肽
Huabin Cai,Peng Wu,Yanling Huang et al.
Huabin Cai et al.
Detection of glutathione (GSH) in the brain provides critical support for investigating the role of GSH in regulating brain function and the mechanism of related diseases. Regulation of the current going through the microchannel can regulat...
Indicator-Free Detection of Hyaluronidase Based on a Conductivity-Regulated Bipolar Electrochemiluminescence Platform [0.03%]
一种基于导电调节型双极电致化学发光平台的透明质酸酶无标记检测方法
Jiancong Ni,Xiaochun Xu,Bifang Yang et al.
Jiancong Ni et al.
Hyaluronidase (HAase) detection plays a critical role in cancer diagnosis and treatment. Most HAase biosensors require the incorporation of exogenous indicators into the sensing reaction for signal transduction, which might involve complex ...