Integrated Microbiome and Metabolome Analysis for Characterization and Discrimination of Saliva, Semen, Vaginal Secretions, and Their Mixtures [0.03%]
Yu Deng,Xiaoyuan Zhen,Ruocheng Xia et al.
Yu Deng et al.
Body fluid identification (BFID) and estimation of time since deposition (TsD) are valuable yet challenging in forensic practice. Previous studies have demonstrated that integrating microbial and metabolomic profiles provides complementary ...
Jessica S Dale,Emma N Welbourne,Caroline A Evans et al.
Jessica S Dale et al.
Mass spectrometry-based approaches have emerged as powerful tools for the analysis of a wide range of critical quality attributes of mRNA medicines, including sequence identity, 5' capping efficiency, and 3' poly(A) tail length and heteroge...
Fluidly Confined CRISPR-Magnetic Microbots Empowered Homogeneous Electrochemical Biosensor for Amplified Detection and Discrimination of Cancer-Derived Extracellular Vesicle Subtypes [0.03%]
Limin Yang,Huilin Tan,Yujue Wang et al.
Limin Yang et al.
Accurate identification and profiling of multiple protein biomarkers on tumor-derived extracellular vesicles (tEVs) are crucial for noninvasive cancer subtyping diagnosis but remain technically challenging due to their high heterogeneity, l...
Fluorination Using PFAS Reagents Generated by Mass Spectrometry [0.03%]
利用质谱法生成的全氟烷基磺酸（PFAS）试剂进行氟化反应
Brison A Shira,Jia Chen,Thomas C Sams et al.
Brison A Shira et al.
We report tandem mass spectrometry (MS/MS) experiments using a modified commercial quadrupole ion trap (QIT) mass spectrometer in which perfluoroalkyl and polyfluoroalkyl substances (PFAS) are fragmented to yield difluorocarbene, a neutral ...
Bacterial Metabolism-Driven Dual-Enzyme Cascade Colorimetric Sensor for Antimicrobial Susceptibility Testing with Readily Interpretable Signals [0.03%]
Xin Zhang,Bangbi Weng,Yuliang Li et al.
Xin Zhang et al.
The global antimicrobial resistance (AMR) crisis urgently necessitates rapid phenotypic antimicrobial susceptibility testing (AST) to reduce empirical antibiotic prescribing and enable targeted antimicrobial therapy. Conventional phenotypic...
A Wireless Passive RFID-Integrated Sensor for the Detection of Pb2+ in Soil: An Innovative Method Using Impedance Mismatch for On-Site Detection of Heavy Metals [0.03%]
Zuozheng Ding,Chengjie Gu,Lingling Yang et al.
Zuozheng Ding et al.
In this study, a wireless passive radio frequency identification (RFID) integrated sensor was proposed for on-site rapid detection of Pb2+ in soil, eliminating the need for intricate detection circuits or high-cost equipment (e.g., vector n...
Zhaomin Yao,Haonan Shangguan,Weiming Xie et al.
Zhaomin Yao et al.
Biological matrix data are essential for computational analysis, providing a structured framework to identify patterns and relationships in biological systems. Many other biological data types, including sequences, networks, and images, can...
Two-Color Digital Immunoassay for Simultaneous Detection of Low-Abundance Neurodegenerative Disease Protein Biomarkers [0.03%]
Ruiying Peng,Daian Chen,Ting Deng et al.
Ruiying Peng et al.
We developed a novel two-color digital immunoassay platform for the simultaneous detection of neurodegenerative disease protein biomarkers (neurofilament light chain (NfL) and interleukin-6 (IL-6)) in a homogeneous, wash-free format. This m...
Hugo G Machado,Elliott P Mueller,Júlio C O Ribeiro et al.
Hugo G Machado et al.
Stable isotope analysis is a vital tool across chemistry, geology, and environmental science, but conventional Isotope Ratio Mass Spectrometry (IRMS) techniques have limited capabilities for site-specific or multiply substituted ("clumped")...
Shedding Light on the Past: Temporal Classification of Zoological Specimens from Museum Collections with Portable NIR Sensors and Multivariate Error Modeling [0.03%]
Jordi Riu,Barbara Giussani,Manuel Monti et al.
Jordi Riu et al.
Museum scientific collections preserve invaluable biological archives that provide insights into historical biodiversity and environmental change. Determining the age of specimens often relies on destructive, labor-intensive, and costly met...