Triple-Template Molecularly Imprinted Electrochemical Sensor Based on Ni,Co/NC@CNTs Derived from ZIF-67 for Highly Sensitive Simultaneous Detection of Dihydroxybenzene Isomers [0.03%]
基于ZIF-67衍生的Ni，Co / NC @ CNT的三模板分子印迹电化学传感器，可高度灵敏地同时检测二羟基苯异构体
Maoyuan Hu,Jinmi Zhang,Li Xu et al.
Maoyuan Hu et al.
The structural and chemical similarities of isomers pose significant challenges for their accurate and simultaneous determination. In this study, for the first time, a novel triple-template molecularly imprinted electrochemical sensor (MIP-...
Hollow Alumina Spheres: Fabrication, Characterization, and Their Potential for Operando Magnetic Resonance [0.03%]
中空氧化铝微球的制备及其表征和原位磁共振研究潜在应用
Elizaveta S Kononenko,Ivan V Skovpin,Dudari B Burueva et al.
Elizaveta S Kononenko et al.
Magnetic resonance (MR) techniques, including nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI), are powerful noninvasive tools for in situ and operando investigations of catalytic processes. However, their ...
Rational Design of a Novel Dual-Functional Fluorescent Probe for Simultaneous Monitoring and Imaging of Mitochondrial CO and ATP Fluctuations during Drug-Induced Liver Injury without Spectral Crosstalk [0.03%]
一种新型双功能荧光探针的合理设计用于在药物引起的肝损伤过程中同时监测和成像线粒体CO和ATP波动（无需谱线交叉干扰）
Xin Zhou,Yuhan Luo,Shixiong Jin et al.
Xin Zhou et al.
Drug-induced liver injury (DILI) poses a terrible threat to human health. Carbon monoxide (CO) is documented to have hepatoprotective effects by relieving hepatic oxidative stress caused by DILI, and adenosine-5'-triphosphate (ATP) has been...
Analytical Determination of Deuterium Atomic Fraction in Hydrogen Isotopes via Quadrupole Mass Spectrometry: Real-Time Monitoring in Liquid-Phase Catalytic Exchange [0.03%]
利用四极杆质谱分析氢同位素中的氘原子分数：液相催化交换过程中的实时监测
Debasish Mandal,Hansol Choi,Hansung Kim
Debasish Mandal
Accurate quantification of deuterium (D) atomic fractions is fundamental to a wide range of scientific and technological applications involving hydrogen isotopes. This study introduces a novel analytical method for accurately estimating deu...
A Hierarchical Model for Longitudinal and Intraparticle Diffusion Coefficients in Liquid Chromatography [0.03%]
液相色谱纵向和颗粒内扩散系数的经验模型研究
Alessandra Adrover,Gert Desmet
Alessandra Adrover
The model for the effective longitudinal diffusion coefficient Deff, recently derived from the two-zone moment analysis approach, is adapted to predict the intraparticle diffusion coefficient Dpart of the general rate model for chromatograp...
Deep Raman Quantitative Profiling and Augmented Features for Biologically Interpretable GI Cancer Detection [0.03%]
深度拉曼定量 profiling 和生物可解释的 GI 癌症检测增强特征
Mingkun Wang,Juan Li,Wenbo Mo et al.
Mingkun Wang et al.
Early diagnosis of gastrointestinal (GI) cancer is critical. Raman spectroscopy combined with deep learning offers a noninvasive molecular quantification approach. This study developed a synergistic framework integrating Raman spectroscopy ...
Cholesterol-Anchored AND-Logic NIR-II Probe for Triple-Responsive Atherosclerosis Imaging [0.03%]
胆固醇锚定与逻辑NIR-II探针用于三重响应动脉粥样硬化成像
Qing-Qing Ye,Han Zhu,Liang Zhao et al.
Qing-Qing Ye et al.
Early detection of atherosclerosis (AS) is crucial to preventing fatal cardiovascular events, but current imaging still lack sensitivity for early atherosclerotic plaques and microenvironmental risk biomarkers. Here, we developed NKH-CHOL, ...
Apoptotic Body-Hitchhiked Manganese-Based Biomimetic Nanoprobe for Sensitive Magnetic Resonance Imaging of Bacteria Triggering Peritoneal Dialysis-Associated Peritonitis In Vivo [0.03%]
一种用于体内灵敏的磁共振成像检测腹膜透析相关性腹膜炎致病菌的基于锰的仿生纳米探针
Maojuan Liu,Yunhe Li,Yang Song et al.
Maojuan Liu et al.
Peritoneal dialysis-associated peritonitis (PDAP), primarily caused by bacterial infections, is a severe complication and a major contributor to mortality in peritoneal dialysis patients. Early detection of bacterial infections and prompt t...
Universal Low-Background Fluorophore Platform via Structural Reprogramming of Oxazine 1 with Julolidine for Activatable Probe Design [0.03%]
通过OXZ-1的结构重新编程与 julolidine 结合构建通用型低本底荧光团平台用于激活探针设计
Dianfeng Dai,Zhimin Zhang,Mo Ma et al.
Dianfeng Dai et al.
Fluorescent probes play a vital role in biological detection and imaging; however, their application is often hampered by high background fluorescence, which compromises detection sensitivity and reduces the signal-to-noise ratio. Oxazine 1...
An RCA-CRISPR-Enhanced SERS Platform for Ultrasensitive and Single-Nucleotide-Resolved Detection of Exosomal miRNA-21 in Early Lung Cancer [0.03%]
用于早期肺癌外泌体miRNA-21超灵敏和单核苷酸分辨率检测的RCA-CRISPR增强型SERS平台
Jialin Teng,Yanping Chen,Wenwen Zhang et al.
Jialin Teng et al.
Exosomal miRNA-21 has emerged as a promising biomarker for early-stage lung cancer due to its close association with tumor progression and its stability in circulation. However, its low abundance, short sequence length, and high-sequence si...