Multimodal Raman and Fluorescence Lifetime Imaging: A New Analytical Approach for Resolving Timing-Dependent Metabolic Recovery in Endothelial Dysfunction [0.03%]
用于解析内皮功能障碍中与时间相关代谢恢复的多模态拉曼和荧光寿命成像新分析方法
Anna Pieczara,Julian Plitzko,Aleksandra Borek-Dorosz et al.
Anna Pieczara et al.
Endothelial dysfunction involves profound metabolic and biochemical disturbances that disrupt vascular homeostasis, yet temporal recovery patterns remain analytically underexplored. This study presents a high-content analytical platform int...
DNA-Alkyne-Chain Probes Enable N-Glycosite-Resolved GlycoBarcoding of Cell-Surface Proteins [0.03%]
DNA-叠烯链探针能够对细胞表面蛋白质进行N连接糖基位点解析的糖编码甘Barcode技术研究
Huimin Bao,Yao Yao,Rui Zhang et al.
Huimin Bao et al.
Cell surface glycoproteins are vital mediators of intercellular communication and primary targets for therapeutic intervention. However, the comprehensive profiling of the "surface glycome" on living cells remains hindered by the low abunda...
Reviving Data Potential─The Reanalysis-Driven Metabolomics Data Repository MB-POST [0.03%]
复兴数据潜能——基于数据再分析的代谢组学数据库MB-POST
Yushi Takahashi,Akiyasu C Yoshizawa,Takato Kiuchi et al.
Yushi Takahashi et al.
Metabolomics investigates an extraordinarily broad chemical space and generates experimental data with substantial potential for reuse in chemistry, biology, and related fields. We developed MB-POST (https://repository.massbank.jp), a new m...
Logic-Gated Autocatalytic DNA Walker for Dual-miRNA Imaging in Living Cells and Clinical Tissues [0.03%]
用于活细胞和临床组织中双miRNA成像的逻辑门控自催化DNA行者
Liuting Mo,Danting He,Yi Zeng et al.
Liuting Mo et al.
DNA-based nanomachines hold great promise for intracellular miRNA sensing and cancer diagnosis. However, conventional approaches often suffer from insufficient sensitivity and specificity, which limits their applicability in clinical diagno...
Ga/Zn Single-Atom Nanozyme-Based Colorimetric Sensor Array for High-Throughput Identification of Tetracyclines [0.03%]
基于镓/锌单原子纳米酶的比色传感器阵列用于四环素类抗生素的高通量检测
Shuang Liang,Dongyao Chen,Liming Ma et al.
Shuang Liang et al.
The issue of tetracycline (TC) residues in the environment poses a serious threat to ecosystems and public health, therefore, there is an urgent need to develop efficient and convenient detection methods. This study successfully prepared Ga...
On-Site Pooled Screening of Genetically Modified Crops via an Integrated Centrifugal Digital Microfluidic Platform [0.03%]
一种集成式离心数字微流体装置实现转基因作物现场混合筛查
Yangyang Wang,Jize Li,Wenhua Huang et al.
Yangyang Wang et al.
The identification of genetically modified crops is extensively employed across diverse agricultural testing scenarios, especially at customs and ports. However, the current methods that rely on laboratory settings are unable to perform nuc...
An Electro-Fenton-Driven Self-Ratio Electrochemiluminescence Sensing Platform without a Coreactant for Sensitive and Accurate Monitoring of Antibiotics [0.03%]
无核心反应剂的电芬顿驱动自比值电化学发光传感平台用于抗生素的灵敏准确监测
Jia Wang,Xianzhen Song,Lu Zhao et al.
Jia Wang et al.
A ratiometric electrochemiluminescence (ECL) sensor with a self-calibration function can significantly enhance the detection accuracy of analytes. However, the requirement for two suitable ECL emitters and their corresponding coreactants of...
Harnessing Hydrogen-Bonded Organic Frameworks as Biosafe MRI Contrast Agents for Tumor Detection and Guided Surgery [0.03%]
利用生物安全性的氢键有机框架作为磁共振成像对比剂用于肿瘤检测和手术导航
Xiang Zhou,Wanjia Wu,Zilong Deng et al.
Xiang Zhou et al.
Gadolinium (Gd)-based magnetic resonance imaging (MRI) contrast agents (CAs) suffer from limitations including rapid renal clearance and potential biological risks, highlighting the urgency to develop safer and more efficient alternatives. ...
A Fundamental Source of Misclassification in Single-Concentration Binding Screens [0.03%]
单浓度结合筛选中误分类的基本来源
Tong Ye Wang,Toby Chan,Svetlana M Krylova et al.
Tong Ye Wang et al.
High-throughput screening of large compound libraries is central to drug discovery and chemical probe development. Primary screens typically test each compound at a single concentration and classify hits according to whether the measured si...
Dual-Mode Turn-On Fluorescent and Ratiometric Electrochemical Detection of Cu2 + in Alzheimer's Disease Mouse Brains Based on a Single Resorufin-Picolinate Probe [0.03%]
基于罗丹明-ピコリン酸单探针的阿尔茨海默病小鼠大脑中Cu2 +双模式开启型荧光及比率型电化学检测法
Hui Dong,Xiaoyu Lv,Yujia Qian et al.
Hui Dong et al.
Copper ions (Cu2+) are closely implicated in the pathogenesis of Alzheimer's disease (AD) by mediating oxidative stress and promoting β-amyloid (Aβ) aggregation. Accurate quantification of labile Cu2+ in the brain extracellular microenvir...