Multiplexed Single-Molecule Detection of Nucleic Acid Biomarkers with a Distance-Tuned Single FRET Pair [0.03%]
一种距离可调的单对荧光共振能量转移技术用于核酸生物标志物的多重单分子检测
Srishty Sethi,Kalani M Wijesinghe,Md Monirul Islam et al.
Srishty Sethi et al.
Biomarkers have gained tremendous attention in recent years, as they offer reliable detection of diseases such as cancers and other health conditions. However, with the recent realization that one biomarker can be associated with more than ...
Development of SPQC Biosensor for Streptococcus pneumoniae Detection Based on IscB Nuclease Recognition [0.03%]
基于IscB核酸酶识别的SPQC生物传感器的研制用于肺炎链球菌检测
YiFan Sun,YuSheng Liao,Fengjiao He
YiFan Sun
Streptococcus pneumoniae is a major pathogen responsible for a wide range of infectious diseases in humans and is also the bacterium that causes the most deaths in children. Consequently, the rapid and accurate detection of S. pneumoniae is...
Multisignal Proportional Optical Chiral Sensing: Photoresponsive Molecular Probe with High Enantioselectivity for Stereospecific Molecular Recognition [0.03%]
多信号比例光学旋光传感：高对映体选择性的光响应分子探针实现立体分子识别
Fawei Zhu,Xiang Wang,Weikang Peng et al.
Fawei Zhu et al.
The differences in the spatial structures of chiral enantiomers often lead to variations in physiological activity. Focusing on the stereoselective behavior of chiral enantiomers, timely and accurate risk assessment has become an important ...
Anion Exchange Chromatography to Determine mRNA Encapsulation in Lipid Nanoparticles [0.03%]
采用离子交换色谱法测定脂质纳米颗粒中的mRNA包裹率
Athanasios Tsalmpouris,Sofiane Mahjoubi,Camille Malburet et al.
Athanasios Tsalmpouris et al.
Encapsulation efficiency (EE) of mRNA-based therapeutics and vaccines is defined as the percentage of total mRNA that is efficiently protected by the delivery vehicle from nuclease degradation. As a critical quality attribute, EE must be as...
Localized Detection of Superoxide Generation and Monitoring of Photosensitizer Performance in Hypoxic Tumors by an In Situ Precipitating Fluorescent Probe [0.03%]
一种新型沉淀型荧光探针用于低氧环境下检测超氧阴离子并监测光敏剂的活性
Liangchao Yuan,Yuyao Cao,Yangtian Liu et al.
Liangchao Yuan et al.
Type I photodynamic therapy (PDT), generating superoxide anion radicals (O2•-), presents a potent strategy against tumor resistance by virtue of its low oxygen dependence, ensuring efficacy in hypoxic tumors where traditional Type II PDT i...
Bimetallic-Doped Metal-Organic Gel for Efficient Electrochemiluminescence: Staircase-Mediated Energy Transfer and Applications in Epinephrine Detection [0.03%]
一种用于高效电致化学发光的双金属掺杂金属有机凝胶及其应用于肾上腺素检测中的级联能量传递机制研究
Jiancong Ni,Ya Xiong,Guiyun Zhang et al.
Jiancong Ni et al.
This study presents the development of a novel bimetallic-doped metal-organic gel (Tb-Eu-MOG) synthesized by codoping terbium (Tb(III)) and europium (Eu(III)) with the Hcptpy ligand and explores its application in electrochemiluminescence (...
MOF-Assisted Nanocellulose Paper-Based Platform for Multiple Surface-Enhanced Raman Scattering Detection [0.03%]
金属有机骨架增强的纳米纤维素纸基底用于表面增强拉曼散射检测多功能平台
Wenwen Yuan,Keran Jiao,Ruiqi Yong et al.
Wenwen Yuan et al.
Metal organic frameworks (MOFs), crystalline solids consisting of organic ligands and metal ions, have attracted increasing interest in various areas, including catalysis and biology. Functionalizable pore interiors and ultrahigh surface-to...
Theoretical Framework and Experimental Validation of Multiplexed Analyte Quantification Using Cross-Reactive Affinity Reagents [0.03%]
基于交叉反应亲和试剂的多重化分析物定量的理论框架和实验验证
Sharon S Newman,Linus A Hein,Alexandra M Adams et al.
Sharon S Newman et al.
Gold standard immunoassays depend on specific affinity reagents for accurate molecular quantification. Any cross-reactivity of affinity reagents, wherein the reagent nonspecifically binds to unintended molecules, can create false positive b...
Application of Rapid Evaporative Ionization Mass Spectrometry (REIMS) to Identify Antimicrobial Resistance in Uropathogenic Escherichia coli (UPEC) Isolates via Deuterium Isotope Probing [0.03%]
使用快速蒸发电离质谱(REIMS)和氘同位素示踪鉴定尿路致病性大肠杆菌(UPEC)的耐药性
Sahand Shams,Sara Sadia Chowdhury,Joel Doherty et al.
Sahand Shams et al.
Antimicrobial resistance (AMR) continues to pose a significant threat to global health, undermining advances in modern medicine and increasing mortality from previously treatable infections. Rapid and accurate antimicrobial susceptibility t...
Improvement of Electrospray Ionization Response Linearity and Quantification in Dissolved Organic Matter Using Synthetic Deuterated Internal Standards [0.03%]
利用合成的氘代内标改善溶解性有机物中电喷雾电离响应线性和定量能力
Alexander J Craig,Mustapha A Ganiyu,Lindon W K Moodie et al.
Alexander J Craig et al.
Aquatic dissolved organic matter (DOM) is an ultracomplex mixture of compounds covering a wide range of masses and with an unknown extent of isomeric complexity, making its structural elucidation and quantification highly challenging. Elect...