Negative Gaseous Ions in Positive-Voltage Electrospray Ionization Mass Spectrometry [0.03%]
高压电喷雾离子化质谱中的负离子
Xing-Bo Wang,Ochir Ochirov,Bo-Cheng Ke et al.
Xing-Bo Wang et al.
Here, we report a serendipitous observation of negative ions in positive-voltage electrospray ionization (ESI) mass spectrometry (MS). Several previous studies have demonstrated that electrospray operated with positive voltage can generate ...
Anti-interference Photoelectrochemical Immunosensing of Staphylococcal Enterotoxin A Using a Dendritic Peptide Tetramer-Modified HsGDY/Cu2O Photocathode [0.03%]
基于树枝状肽四聚体的HsGDY/Cu2O光电阴极的耐干扰金黄色葡萄球菌肠毒素A光免疫传感检测法
Wei Li,Xiaotong Lin,Gao-Chao Fan et al.
Wei Li et al.
Staphylococcal enterotoxin A (SEA) is a major foodborne pathogen toxin capable of causing severe food poisoning even at nanogram levels. However, as widely reported, accurate quantification of SEA in complex food matrices remains challengin...
Pronounced Fluorescence Polarization Enhancement Driven by RPA-CRISPR/Cas12a Induced Nucleoprotein Assembly for Salmonella Analysis in Animal-Derived Food Matrices [0.03%]
由RPA-CRISPR/Cas12a诱导的核蛋白组装增强荧光偏振法用于动物源性食品基质中沙门氏菌分析
Zhuqi Sui,Baoqiang Chen,Jia Zhao et al.
Zhuqi Sui et al.
Salmonella is one of the most hazardous foodborne pathogens, posing a serious threat to public health and food safety worldwide. Conventional recombinase polymerase amplification (RPA)-CRISPR/Cas12a detection assays predominantly rely on th...
Catalytic Amplification-Mediated Single-Nanotag Assembly for Sensitive Detection of Circulating microRNAs [0.03%]
用于灵敏检测循环microRNA的催化放大介导单纳米标签组装法
Xiao Chen,Chengchao Zhang,Hui Yin et al.
Xiao Chen et al.
Circulating microRNAs are promising cancer biomarkers, which are characterized by low abundance, small size, and high sequence homology. As such, enzyme-assisted amplification strategies are often indispensable, which sometimes complicates ...
High Coverage Quantitative Lipidomic Analysis for Multiple Biological Matrices Using Ultrahigh-Performance Liquid-Chromatography and Tandem Mass Spectrometry [0.03%]
基于超高压液相色谱和串联质谱的多生物基质高覆盖定量脂质组分析方法
Qinsheng Chen,Chenhan Zhang,Xiaoli Zhang et al.
Qinsheng Chen et al.
The lipid composition (lipidome) in biological samples is extremely complex, having diverse biofunctions. Quantifying lipidomes with high coverage is vital to understand such functions but challenging due to their levels spanning several or...
Effective Removal of Ar-Based Spectral Interferences Using Sulfur Hexafluoride in ICP-MS/MS: Applications to In Situ K-Ca Geochronology [0.03%]
基于SF6的ICP-MS/MS有效消除Ar质谱干扰及其在原位K-Ca定年中的应用
Junlong Niu,Shitou Wu,Yueheng Yang et al.
Junlong Niu et al.
Inductively coupled plasma-mass spectrometry (ICP-MS) using Ar as the plasma gas has been used successfully in many diverse fields; however, Ar-based spectral interferences (e.g., 38Ar1H+, 40Ar+, 40Ar16O+, and 40Ar40Ar+) limit the precise a...
Rational Design of Amperometric Sensor Based on Magnesium Oxide and Reduced Graphene Oxide Hybrid for Ultralow Detection of Cephalexin in Complex Biological Matrices [0.03%]
基于镁氧化物和还原型石墨烯氧化物杂化材料的氨法传感器的理性设计，用于复杂生物基质中头孢列新超痕量检测
Jamil A Buledi,Saba Ali,Iuliia Golovynska et al.
Jamil A Buledi et al.
Cephalexin (CEX) is the first-generation β-lactam antibiotic drug used to treat urinary, respiratory, and skin infections. However, the overtherapeutic use of CEX necessitates its accurate and low-level monitoring in biological and clinica...
Jonathan V Sweedler
Jonathan V Sweedler
Hitting Two Birds with One Stone: Magnetism-Fluorescence Janus Composites for Simultaneous Targeting of Serum Exosomes and Trapping of Phosphoproteins [0.03%]
一石二鸟：同时靶向血清外泌体和捕获磷酸化蛋白质的磁荧光Janus复合材料
Junwei Yang,Haijiao Zheng,Xiaolei Lv et al.
Junwei Yang et al.
Designing a highly efficient serum exosome (sEV) phosphorylation proteomics platform with specific sEV targeting and phosphoprotein trapping for biomarker identification in renal cell carcinoma (RCC) is challenging. Herein, we fabricated a ...
Evaluation of Intermolecular Interactions in HPLC Using Deuterated Mobile Phases [0.03%]
利用氘代流动相评价高压液相色谱中的分子间作用力
Kosuke Amano,Eisuke Kanao,Sayaka Konishi Yamada et al.
Kosuke Amano et al.
Deuterium, a stable isotope of hydrogen, is widely used in analytical and pharmaceutical sciences; however, its influence on intermolecular interactions remains poorly understood. This study aims to clarify the effect of solvent deuteration...