Self-Enhanced Ratiometric ECL Strategy Based on a Dual-Emission Ce/Tb-MOF Luminophore with Spatially Resolved Coreactant Delivery for Ultrasensitive Pro-GRP Detection [0.03%]
一种基于Ce / Tb-MOF比率型ECL发光体的自增强式超灵敏前促肾上腺皮质中瘤素检测技术
Dewen Yan,Yue Zhang,Weiming Gong et al.
Dewen Yan et al.
Dual-signal-output ratiometric electrochemiluminescence (ECL) platforms offer a promising solution to address the instability and inaccuracies associated with single-signal ECL detection. However, most existing ratiometric systems still rel...
Multisignal Conversion Electrochemiluminescence Strategy Based on Nanozyme-Enhanced Nitrogen-Vacancy/Oxygen-Doped g-C3N4 for the Detection of Cholesterol [0.03%]
基于纳米酶增强的氮空位/氧掺杂g-C3N4的多信号转换电化学发光策略检测胆固醇
Guping Zhang,Xiaodi Li,Yao Wang et al.
Guping Zhang et al.
The high and stable signal intensity of electrochemiluminescence (ECL) is crucial for establishing highly sensitive ECL biosensors. Here, nitrogen-vacancy/oxygen-doped carbon nitride (OCNNV-650) was first used as an ECL emitter, significant...
Deep Structural Characterization of Protein-Bound Lipids via Native MS and Ultraviolet Photodissociation [0.03%]
基于原位质谱及紫外光解吸的蛋白结合脂质的深度结构表征
Carla Kirschbaum,Jack L Bennett,Carol V Robinson
Carla Kirschbaum
Protein-lipid interactions are critical for maintaining membrane protein structure and regulating diverse protein functions. Native mass spectrometry (MS) has emerged as a powerful technique for the direct observation and characterization o...
Multicyclic Ligation-Driven Self-Assembly of Magnetic Nanobundles for Sensitive Profiling of Multiple Repair Glycosylases in Cancer Cells [0.03%]
多重环化交联驱动的磁性纳米束自组装用于癌细胞中多种修复糖基化酶灵敏谱图分析
Jie Gao,Qian Han,Hao Liu et al.
Jie Gao et al.
Base excision repair (BER) enzymes are essential for maintaining genomic stability and contribute significantly to disease pathogenesis, but simultaneous monitoring of multiple BER enzymes remains a challenge due to their mechanistic divers...
Tunable Detection of MicroRNA-21 in Cancer Cells Using a 3D DNA Walker Mediated by Remote Toehold Strand Displacement Reaction [0.03%]
基于远程衔接链置换反应的三维DNA步行器在肿瘤细胞中实现microRNA-21的检测
Saimei Zhang,Jiangxue Dong,Yanping Zhao et al.
Saimei Zhang et al.
Finely tunable detection of microRNAs (miRNAs) is crucial for personalized medicine and cancer diagnosis, and it is a challenge to construct a tunable sensor for miRNA detection due to the diversity and complexity of cancer patient samples....
Probe-Encapsulated and Cell-Membrane-Anchored DNA Nanotoolboxes Enable In Situ Imaging of Extracellular Biochemical Components in Complex Biological Media [0.03%]
基于DNA纳米工具箱的探针示踪技术实现复杂生物体系中胞外生化组分的原位成像研究
Linlin Wang,Su Zhou,Qin Li et al.
Linlin Wang et al.
Cell-membrane-anchored DNA probes are powerful tools for membrane-localized biosensing, bioregulation, and biotherapy studies. However, the poor biostability, membrane-anchoring stability, and effectiveness of membrane-anchored DNA probes i...
Cu-Based Nanozyme-Enabled Triple Channel Colorimetric Sensor Arrays for Efficient Discrimination of Flavonoids [0.03%]
一种高效的黄酮类化合物鉴别三通道比色传感器数组及铜基纳米酶促其显色反应研究
Qilin Zhao,Tian Luan,Jian Sun et al.
Qilin Zhao et al.
The accurate identification and quantification of flavonoids are crucial but remain highly challenging, which is attributed to their analogous structures and properties. Based on different and unique cross reactions between receptors and an...
Pulse-Operated First-Generation Biosensors with Extended Linear Range for Continuous Glycemia Monitoring in Oxygen-Deficient Environments [0.03%]
用于缺氧环境连续监测血糖的第一代脉冲式生物传感器的线性范围扩展研究
Maria A Komkova,Valeria S Kasimovskaya,Artem A Eliseev et al.
Maria A Komkova et al.
We report on the Prussian Blue (PB) and glucose oxidase (GOx) based first-generation biosensor with a linear calibration range remarkably extended to high concentrations, which is suitable for continuous monitoring in oxygen-deficient media...
Quick Determination of Fourteen Rare Earth Elements in Powdered Refractory Materials Using Electrothermal Vaporization with Detection by Inductively Coupled Plasma Optical Emission Spectrometry [0.03%]
采用电热蒸气发生-感应耦合等离子体光发射光谱法快速测定难熔粉未材料中的14种稀土元素
Yangyang Wang,Sophia J Kienast,Diane Beauchemin
Yangyang Wang
The determination of rare earth elements (REEs) in refractory materials by inductively coupled plasma (ICP) spectrometry with conventional sample introduction using pneumatic nebulization requires the dissolution of these samples, which is ...
MALDI-TIMS-MS2 Imaging and Annotation of Natural Products in Fungal-Bacterial Coculture [0.03%]
基质辅助激光解吸电离-时间多盘-串联质谱成像及真菌-细菌共培养中天然产物的注释
Robert A Shepherd,Gordon T Luu,Laura M Sanchez
Robert A Shepherd
Mass spectrometry imaging (MSI) is a powerful tool for monitoring the spatial distributions of microbial metabolites directly from culture. MSI can identify secretion and retention patterns for microbial metabolites, allowing for the assess...